Coconut, high fat diet, for Epilepsy and Alzheimer’s Disease

A recent research confirms that Ketone-based diet, high fat and protein with less carbs diet, can help patients with Epilepsy and Alzheimer’s Disease (AD).  The brain uses Ketone aside from glucose to function (glucose function is impaired in AD).

The Ketone-based diet was first discovered when an Epileptic patient followed a hight fat and high protein diet (and low carbs) which reduced her seizures by more than 90% and half her dose of anti-epileptic medications.

Dr. Newport’s comments:
The bottom line here, to try to prevent or stabilize AD, include medium chain fatty acids (coconut oil, palm kernel oil and MCT oil are the richest sources) in the diet to provide ketones as an alternative fuel to glucose AND eat fish (especially salmon) and/or take a supplement of marine based omega-3 oil (fish oil for most of us; algae based oil for vegans found in brands that are marketed to pregnant women).

“…two observations in particular support the notion that the neurons affected in AD are still functional: (1) in AD, brain ketone uptake is apparently normal or at least less impaired than is glucose, and (2) there is a functional response to nutritional supplements that increase brain fuel
availability, particularly ketones. Hence, if brain fuel metabolism could be optimized or even partially returned toward normal, the risk of further cognitive decline may diminish. Raising plasma ketones to 0.4-0.5 mM would contribute to 5-10% of the brain’s energy requirements, which is equivalent to the early cortical glucose deficit in those genetically at risk AD. Such a mild, safe level of ketonemia is achievable with ketogenic supplements, so if implemented before symptoms develop, it seems plausible that they could diminish the risk of further metabolic deterioration and clinical onset of cognitive decline.”

Regarding Omega-3 fatty acids:
“The u3 [omega-3] polyunsaturated fatty acid, DHA, is now widely understood to have an important role in mammalian brain development…Insufficient dietary intake of DHA and low levels of DHA in the hippocampus may have a role in cognitive decline in the elderly and/or AD. Hence, the low intake of DHA now widely but not universally reported in AD may contribute to the evolution of cognitive decline because of its role in brain glucose transport and in other aspects of brain function and structure. This emerging role of DHA in brain energy metabolism could be linked to the early presymptomatic onset of brain glucose hypometabolism in AD, at least in carriers of the e4 allele of apoE4. Nevertheless, such an effect probably involves relatively subtle changes in DHA metabolism because plasma DHA appears to be higher in the healthy elderly and is widely variable in AD.”
Keywords: AD, alzheimer’s disease, alzheimers, brain metabolism, coconut oil, insulin deficiency, ketones, medium chain fatty acids, mitochondrial dysfunction, omega-3 fatty acids, prevention of alzheimer’s

For home-bound seniors in the bayarea who needs a caregiver 24/7, call Motherhealth at 408-854-1883 or email motherhealth@gmail.com

 

 

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