Alzheimer’s Disease and ABCA7 gene, for lipid homeostasis in cells of the immune system

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White).
This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=10347

Connie’s comments: Our lymphatic system cleans our body from waste products/toxins. Our body needs to balance fat metabolism and absorption. There is an increased chance of finding more cancer/abnormal cells in our fat tissues. We have to protect our bodies from toxins by consuming only whole foods, living a lifestyle with less stress and avoidance of toxins or exitotoxicities.

 

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