Zyflamend is a formulation containing ten different herbs. It is marketed as a dietary supplement for healthy inflammation response and normal cardiovascular and joint function (1). Preliminary studies suggest that the ingredients in Zyflamend have anti-inflammatory, antiangiogenic, and antiproliferative properties (2).
Zyflamend also inhibits the proliferation of oral squamous carcinoma (3), pancreatic cancer (4) and melanoma cells in vitro (5).
In an animal model, it inhibited the growth of both hormone-sensitive and hormone-insensitive prostate cancer, and reduced the expression of prostate specific antigen (PSA) (6).
In a Phase I trial in men with prostatic intraepithelial neoplasia (PIN), Zyflamend did not cause any serious adverse events nor significant changes in serum prostate specific antigen (PSA) nor tissue nuclear factor (NF)-kappa B levels. However, a significant reduction in serum levels of C-reactive protein was observed (7). More studies are warranted.
Zyflamend may potentiate the cytotoxic effects of certain chemotherapeutic agents, including gemcitabine (4), taxol (2), doxorubicin (2) and bicalutamide (8). Human data are lacking.
Ocimum sanctum (Holy basil) leaf
Curcuma longa (Turmeric) rhizome
Zingiber officinale (Ginger) rhizome
Camellia sinensis (Green tea) leaf
Rosemarinus officinalis (Rosemary) leaf and essential oil
Polygonum cuspidatum (Hu Zhang) root
Coptis chinensis (Chinese goldthread) root
Berberis vulgaris (Barberry) root
Origanum heracleoticum (Oregano) leaf
Mechanism of Action
Holy basil, turmeric, ginger, green tea, rosemary, hu zhang, Chinese gold thread and Scutellaria inhibit cyclooxygenase-2 (COX-2) activity and thereby reduce inflammation. In vitro studies showed that Zyflamend inhibits inflammatory enzymes, decreases retinoblastoma (Rb) protein phosphorylation (9), and induces apoptosis in human prostate cancer cells (2)(3)(4)(10). Zyflamend also reduced androgen receptor signaling and enhanced bicalutamide-induced apoptosis in prostate cancer cell lines (8). In a murine xenograft model of prostate cancer, Zyflamend was shown to inhibit androgen-dependent tumor growth and histone deacetylase-5, biomarkers linked to prostate cancer progression (6).
Zyflamend reduced the number of inflammatory cells, hyperplasia and dysplasia, tumor incidence and number, and inhibited cell proliferation in an animal model of oral squamous cell carcinoma (3). It inhibited osteoclastogenesis and NF-kappa B activation in myeloid leukemia cells and in lung adenocarcinoma cells as well (2); it inhibited NF-kappa B activation and enhanced gemcitabine-induced apoptosis in pancreatic cancer cells (4).
An in vitro study showed that Zyflamend induces autophagy and apoptosis sequentially in melanoma cells by activating the intrinsic caspase cascade. Cell migration and COX-2 expression were also suppressed (5).
Hypersensitivity to any of the constituents.
Reported: Bad taste in the mouth, heartburn, and diarrhea. (7)
Dosage (Inside MSKCC Only)
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- New Chapter I. Zyflamend – Herbals from New Chapter. 2012; http://www.newchapter.com/zyflamend. Accessed June 29, 2012.
- Sandur SK, Ahn KS, Ichikawa H, et al. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer. 2007;57(1):78-87.
- Yang P, Sun Z, Chan D, et al. Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Carcinogenesis. Nov 2008;29(11):2182-2189.
- Kunnumakkara AB, Sung B, Ravindran J, et al. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. Aug 1 2012;131(3):E292-303.
- Ekmekcioglu S, Chattopadhyay C, Akar U, et al. Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells. Nutr Cancer. 2011;63(6):940-949.
- Huang EC, McEntee MF, Whelan J. Zyflamend, a Combination of Herbal Extracts, Attenuates Tumor Growth in Murine Xenograft Models of Prostate Cancer. Nutr Cancer. Jun 4 2012.
- Capodice JL, Gorroochurn P, Cammack AS, et al. Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. J Soc Integr Oncol. Spring 2009;7(2):43-51.
- Yan J, Xie B, Capodice JL, et al. Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth. Prostate. Feb 2012;72(3):244-252.
- Yang P, Cartwright C, Chan D, et al. Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation. Cancer Biol Ther. Feb 2007;6(2):228-236.
- Bemis DL, Capodice JL, Anastasiadis AG, et al. Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression. Nutr Cancer. 2005;52(2):202-212.
Connie’s comments: My 78 yr old mother can walk now after being bed ridden from arthritis pain for few days with the help of zyflamend, omega oil, massage oil, healthy diet, lemon grass and loving care of support group of caregivers and family.
Connie Dello Buono ; email@example.com
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