Low histamine food or raw foods rich in Vitamin C or whole foods prevents Alzheimer’s disease.
Avoid these high-histamine food, processed foods:
• fermented food
• artificial food colouring, especially tartrazine
• benzoates including food sources of benzoates, benzoic acid and sodium benzoate
• butylated hydroxyanisole (BHA) and butylated hydoxytoluene (BHT)

The Neglected Role of Histamine in Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by beta-amyloid plaques accumulation and cognitive impairment. Both environmental factors and heritable predisposition have a role in AD. Histamine is a biogenic monoamine that plays a role in several physiological functions, including induction of inflammatory reactions, wound healing, and regeneration.
The Histamine mediates its functions via its 4 G-protein-coupled Histamine H1 receptor (H1R) to histamine H1 receptor (H4R). The histaminergic system has a role in the treatment of brain disorders by the development of histamine receptor agonists, antagonists. The H1R and H4R are responsible for allergic inflammation.
But recent studies show that histamine antagonists against H3R and regulation of H2R can be more efficient in AD therapy. In this review, we focus on the role of histamine and its receptors in the treatment of AD, and we hope that histamine could be an effective therapeutic factor in the treatment of AD.

Early warning signs and symptoms of Alzheimer’s disease• Short-term memory loss is the most common early symptom of Alzheimer’s disease. Do you have trouble remembering recent conversations or events?
• Difficulty performing familiar tasks. Are you stumped by everyday activities, like brushing your teeth, washing your hair, or making a telephone call?
• Disorientation. Do you get lost in your own neighborhood? Do you find yourself putting household items in places they don’t belong, like placing a book in the refrigerator?
• Increasing problems with planning and managing. Have activities like balancing your checkbook, paying bills, or preparing a shopping list become more difficult?
• Trouble with language. Are you unable to recall words for everyday things? For example, does “car” become “that thing I drive” or chair “that thing I sit on”?
• Rapid, unpredictable mood swings. Do you suddenly shift from happy to sad or from calm to angry with no apparent reason?
• Lack of motivation. Have activities you have always loved lost their appeal? Do you see less of your friends and family? Are you spending more time staring at the television?
• Changes in sleep. Do you sleep more than usual? Do you sleep during the day rather than at night?

Role of Vitamin D in Alzheimer’s Disease: Possible Genetic and Cell Signaling Mechanisms

Alzheimer’s disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive memory loss and cognitive dysfunction. A significant association between AD and low levels of vitamin D has been demonstrated.
Furthermore, vitamin D supplements appear to have a beneficial clinical effect on AD by regulating micro-RNA, enhancing toll-like receptors, modulating vascular endothelial factor expression, modulating angiogenin, and advanced glycation end products.
Vitamin D also exerts its effects on AD by regulating calcium-sensing receptor expression, enhancing amyloid-β peptides clearance, interleukin 10, downregulating matrix metalloproteinases, upregulating heme oxygenase 1, and suppressing the reduced form of nicotinamide adenine dinucleotide phosphate expression.

In conclusion, vitamin D may play a beneficial role in AD. Calcitriol is the best vitamin D supplement for AD, because it is the active form of the vitamin D3 metabolite and modulates inflammatory cytokine expression. Therefore, further investigation of the role of calcitriol in AD is needed.



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