The Human Circadian Rhythms RT² Profiler PCR Array profiles the expression of 84 key genes defining and regulating the biological clock. Synchronization, or “entrainment”, of the circadian clock occurs via light stimulus of the hypothalamic suprachiasmatic nucleus (SCN) in the brain and via hormone signaling from the SCN in peripheral tissues.
Interacting positive and negative circadian gene feedback loops at the transcriptional and post-translational level set up the circadian “oscillator” and insure tight control over transcription factors regulating expression of the appropriate genes required during circadian days or nights.
Genes regulated by circadian rhythms are involved in a diverse range of biological processes that affect physiology, metabolism, and behavior. Although the circadian rhythm target genes in its “output” pathways vary widely from tissue to tissue, the transcription factors encoded by central clock and clock-controlled genes are mostly shared across all cell types.
Sleeping disorders (such as apnea, insomnia, and desynchronosis) disrupt the timing of the circadian clock, requiring re-entrainment and causing fatigue. Continued disruption of the circadian clock is a source of bodily stress and a risk factor for cancer and cardiovascular disease.
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During sleep, our brain allows toxins to move out of the brain and the immune system to attack these toxins. So sleep more, take calcium and magnesium in the afternoon or at night. Drink decaf coffee only in the morning. Darken the room and find a comfortable bed and environment (cooler temp) to sleep. Take your worries away, meditate and pray.
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