References
- 1 , . High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 2005; 5: 331–42.
- 2 , , et al. A Critical Cysteine is Required for HMGB1 Binding to TLR4 and Activation of Macrophage Cytokine Release. Proc Natl Acad Sci USA 2010; 26: 11942–7.
- 3 . Inflammation 2010: new adventures of an old flame. Cell 2010; 140: 771–6.
- 4 , , et al. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci 2000; 85: 141–7.
- 5 , , et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000; 405: 458–62.
- 6 . The inflammatory reflex. Nature 2002; 420: 853–9.
- 7 , , et al. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 2006; 203: 1623–8.
- 8 , , et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003; 421: 384–8.
- 9 , , et al. Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 2002; 195: 781–8.
- 10 , , et al. Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion. J Vasc Surg 2002; 36: 1231–6.
- 11 , , et al. The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 2006; 130: 1822–30.
- 12 , , et al. The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis. J Infect Dis 2005; 191: 2138–48.
- 13 , , et al. Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med 2007; 35: 2762–8.
- 14 , , et al. Cholinergic agonists attenuate renal ischemia-reperfusion injury in rats. Kidney Int 2008; 74: 62–9.
- 15 , , et al. Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice. Arthritis Rheum 2009; 60: 114–22.
- 16 , , et al. Activation of an efferent cholinergic pathway produces strong protection against myocardial ischemia/reperfusion injury in rats. Crit Care Med 2005; 33: 2621–8.
- 17 , , et al. Adrenocorticotropin reverses hemorrhagic shock in anesthetized rats through the rapid activation of a vagal anti-inflammatory pathway. Cardiovasc Res 2004; 63: 357–65.
- 18 , , et al. Efferent vagal fibre stimulation blunts nuclear factor-kappaB activation and protects against hypovolemic hemorrhagic shock. Circulation 2003; 107: 1189–94.
- 19 , , et al. Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism. Eur J Pharmacol 2010; 637: 124–30.
- CrossRef |
- PubMed |
- CAS |
- Web of Science®
- 20 , , , , , . Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus. J Rheumatol 2010; 37: 766–75.
- 21 . Understanding immunity requires more than immunology. Nat Immunol 2010; 11: 561–4.
- 22 , , et al. Modulation of TNF Release by Choline Requires Alpha7 Subunit Nicotinic Acetylcholine Receptor-Mediated Signaling. Mol Med 2008; 14: 567–74.
- 23 , , et al. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol 2005; 6: 844–51.
- 24 , , et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004; 10: 1216–21.
- 25 , , et al. Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol 2008; 181: 3535–9.
- 26 , . The neurology of the immune system: neural reflexes regulate immunity. Neuron 2009; 64: 28–32.
- 27 , , et al. Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia. Proc Natl Acad Sci USA 2008; 105: 11008–13.
- 28 , , et al. Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b. J Immunol 2009; 183: 552–9.
- 29 , , et al. Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. J Exp Med 2005; 201: 1113–23.
- 30 , . Prevention and management of overwhelming postsplenectomy infection–an update. Crit Care Med 1999; 27: 836–42.
- 31 . Suppression of TNF and other proinflammatory cytokines by the tetravalent guanylhydrazone CNI-1493. Prog Clin Biol Res 1998; 397: 335–43.
- 32 , , et al. Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway. Brain Behav Immun 2009; 23: 41–5.
- 33 , , et al. Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia. Proc Natl Acad Sci USA 2006; 103: 5219–23.
- 34 , , , , . Hypothalamic regulation of pancreatic secretion is mediated by central cholinergic pathways in the rat. J Physiol 2003; 552: 571–87.
- 35 , , . Cholinergic stimulation of the rat hypothalamus: effects of liver glycogen synthesis. Science 1976; 194: 535–6.
- 36 , , , , , . RR interval variability is inversely related to inflammatory markers: the CARDIA study. Mol Med 2007; 13: 178–84.
- 37 Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996; 93: 1043–65.
- 38 , . Analysis of heart rate patterns preceding fetal death. Obstet Gynecol 1977; 50: 578–82.
- 39 , , . Fetal heart rate variability as an indicator of fetal status. Postgrad Med 1980; 67: 207–10, 213–15.
- 40 , , , , . A new modality in nonstress testing: evaluation of beat-to-beat fetal heart rate variability. Am J Obstet Gynecol 1981; 141: 521–6.
- 41 , , , . Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987; 59: 256–62.
- 42 , , , , . Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 1998; 351: 478–84.
- 43 , , . Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992; 85: I77–91.
- 44 , , . Spectral analysis of heart rate variability in the sepsis syndrome. Clin Auton Res 1993; 3: 5–13.
- 45 , , et al. Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Crit Care Med 2005; 33: 1994–2002.
- 46 , , et al. Cardiac autonomic profile in rheumatoid arthritis and systemic lupus erythematosus. Lupus 2010; 19: 255–61.
- CrossRef |
- PubMed |
- CAS |
- Web of Science®
- 47 , , et al. Cardiovascular autonomic dysfunction in systemic lupus, rheumatoid arthritis, primary Sjogren syndrome and other autoimmune diseases. Lupus 2007; 16: 181–5.
- 48 , , , , . Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission. Dig Dis Sci 2009; 54: 853–61.
- 49 , , , , . Autonomic vagal nerve dysfunction in patients with ulcerative colitis. Scand J Gastroenterol 1993; 28: 638–42.
- 50 , , et al. Whole blood cytokine attenuation by cholinergic agonists ex vivo and relationship to vagus nerve activity in rheumatoid arthritis. J Intern Med 2010; 268: 94–101.
- 51 , , et al. Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis. Mol Med 2007; 13: 210–5.
- 52 , , , , , . Relationship of basal heart rate variability to in vivo cytokine responses after endotoxin exposure. Shock 2010; 33: 363–8.
- 53 , , et al. Modulation of brain dead induced inflammation by vagus nerve stimulation. Am J Transplant 2010; 10: 477–89.
- 54 , , , , . From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008; 9: 46–56.
- 55 , , . Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol 2006; 27: 24–31.
- 56 , , . Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009; 65: 732–41.
- 57 , , , , , . Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry 2010; 67: 1067–74.
- 58 , , et al. Two-year outcome of vagus nerve stimulation in treatment-resistant depression. J Clin Psychopharmacol 2010; 30: 273–81.
- 59 , , et al. Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study. Biol Psychiatry 2005; 58: 355–63.
- 60 , , et al. Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes. Biol Psychiatry 2002; 51: 280–7.
- 61 , , et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010; 67: 446–57.
- 62 , , et al. Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men. Am Heart J 2008; 156: 759.e1–7.
- 63 , , , , . The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology 2008; 33: 1305–12.
- 64 , , et al. Heart rate variability and markers of inflammation and coagulation in depressed patients with coronary heart disease. J Psychosom Res 2007; 62: 463–7.
- 65 , , et al. Inflammatory markers and heart rate variability in women with coronary heart disease. J Intern Med 2004; 256: 421–8.
- 66 , , , , . The relationships among heart rate variability, inflammatory markers and depression in coronary heart disease patients. Brain Behav Immun 2009; 23: 1140–7.
- 67 , , et al. High levels of C-reactive protein are associated with reduced vagal modulation and low physical activity in young adults. Scand J Med Sci Sports 2010; July 6. [Epub ahead of Print].
- 68 , , et al. Aerobic exercise attenuates inducible TNF production in