Important points in the development of Alzheimer’s disease:

  • sugar intake [ pancreas health]

  • NSAID intake – acidic meds vs alkaline environment for glial cells health

  • iron, blood homeostasis – blood vessels health from embryo to adulthood

  • stress – brain/body cannot detox [ parathyroid health]

  • lack of sleep – brain cannot detox [ pituitary gland health]

  • bacteria in the gut – travelling to the brain [microbiome]

  • prenatal development and nutrients in the womb

  • glial cells – police in the brain

  • vasoactive intestinal peptide – police in the gut

Summarized by:

Connie Dello Buono

About Vasoactive intestinal peptide (VIP)

Vasoactive intestinal peptide also known as the vasoactive intestinal polypeptide or VIP is a peptide hormone containing 28 amino acid residues. VIP is a neuropeptide that belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors.[1] VIP is produced in many tissues of vertebrates including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain.[2][3] VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.[4]

VIP has a half-life (t½) in the blood of about two minutes.


VIP has an effect on several tissues:


VIP is overproduced in VIPoma.[5] Can be associated with Multiple Endocrine Neoplasia Type 1 (Pituitary, parathyroid and pancreatic tumors). Symptoms are typically:

  • Profuse non-bloody/non-mucoid diarrhea (3L+) causing dehydration and the associated electrolyte disturbances such as hypokalemia and metabolic acidosis.
  • Lethargy and exhaustion may ensuey health