Researchers have uncovered a new molecular pathway for stimulating the body to burn fat – a discovery that could help fight obesity, diabetes and cardiovascular disease.

In a study published in the journal Genes & Development, a team led by researchers from the Department of Biochemistry at McGill University focus on a protein known as folliculin and its role in regulating the activity of fat cells. By knocking out the gene that produces folliculin in fat cells in mice, the researchers triggered a series of biomolecular signals that switched the cells from storing fat to burning it.

Iron-rich mitochondria, an abundance of which is a sign that a cell is in metabolic overdrive

This process is known as the ‘browning’ of fat cells. Brown fat gets its colour from iron-rich mitochondria, an abundance of which is a sign that a cell is in metabolic overdrive.

Heat and body temp

The principal role of brown fat is to burn energy to produce heat, which helps keep our body temperature constant. White fat serves as an energy-storage tissue.

Make active fat tissue cells to easily burn them

Scientists recently discovered a new type of fat tissue with characteristics somewhere between healthy brown fat and the not-so-healthy white kind. So-called beige fat is capable of behaving like brown fat in response to certain stimuli such as exposure to cold. The more active these cells are, the less likely we are to accumulate unhealthy fat deposits that lead to obesity. Since the discovery of beige fat, the challenge has been to find ways to convert white fat cells into energy-burning beige ones.

“Conversion from white fat cells to beige or brown fat cells is a very desirable effect in the obesity, diabetes, and metabolic syndrome indications, since excess energy in the body is not stored in fat tissue but is burned in brown or beige fat tissue,” said professor Arnim Pause, the study’s senior author.

In collaboration with Vincent Giguère, the team bred mice to have fat cells that did not produce folliculin. They then fed normal mice and folliculin-deficient mice with a high-fat, junk food-like diet over 14 weeks. Normal mice gained weight rapidly, whereas folliculin-deficient mice remained slim and did not suffer the same elevated insulin and triglyceride levels. By measuring rates of oxygen consumption and CO2 production, the researchers found the folliculin-deficient mice were burning more fat. At the end of the trial, these mice had smaller white fat cells and less white fat tissue overall. The extra energy they were producing made them better at tolerating cold temperatures, too.

Mitochondria in fat cells

The breakthrough builds on existing knowledge about two key proteins – PGC-1α and ERRα – and their involvement in regulating mitochondria in fat cells. The researchers, led by graduate student Ming Yan, and Etienne Audet-Walsh, a postdoctoral fellow, found that removing folliculin gives the enzyme known as AMPK free rein to activate these proteins, boosting the number and work rate of the mitochondria in the fat cell. The result is a metabolic reprogramming of fat tissue, turning cells from fat storage units into fat burning engines. By pinpointing the folliculin pathway, the work has potentially opened the way for new medications to be developed that will stimulate the ‘browning’ process.


Soak and ferment Nuts and grains and combine Vitamin C and Iron rich foods to facilitate weight loss



Preparing Grains, Legumes, Nuts, and Seeds to Reduce Phytic Acid


Reduce phytic acid in food is by soaking and fermentation. If you place the food in warm water for hours, the content of phytic acid will decrease or may disappear entirely. There are some exceptions for which it is difficult to remove the phytic acid (soy and corn – not to be eaten when trying to lose weight).

For much of the rest of the food world, you can improve the phytic acid reduction by soaking a ground version of the food (cracked or ground grains, chopped nuts). You can also improve your iron absorption by eating these foods with high vitamin C foods such as tomatoes, peppers, and oranges.

Vegetables High in Oxalic Acid must be boiled


For vegetables high in oxalic acid, your best strategy is to boil them and discard the boiling water. Eating foods high in vitamin C along with your vegetables may help as well, especially if you are boiling all of the vitamin C out of your spinach.



Brown fat

Source: McGill University.


McGill-led discovery could help fight obesity, metabolic disorders.

Note: Eat iron rich foods in the morning and calcium+magnesium rich foods in the afternoon and evening. Always with Vitamin C rich foods for easy absorption.


Connie Dello Buono 

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