If a certain part of your skin's immune system fails, will it not cause inflammatory reacti… by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Lysosomal system participates in numerous pathologic processes in skin including epidermal phagocytosis, inflammation and neoplasia.
The lysosomes also act as the waste disposal system of the cell by digesting unwanted materials in the cytoplasm, both from outside of the cell and obsolete components inside the cell. Material from the outside of the cell is taken-up through endocytosis, while material from the inside of the cell is digested through autophagy.
Our skin is the largest organ in the body.
From: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1022320/
As a protective interface between internal organs and the environment, the skin encounters a host of toxins, pathogenic organisms, and physical stresses. To combat these attacks on the cutaneous microenvironment, the skin functions as more than a physical barrier: it is an active immune organ. Immune responses in the skin involve an armamentarium of immune-competent cells and soluble biologic response modifiers including cytokines. Traversed by a network of lymphatic and blood vessels, the dermis contains most of the lymphocytes in the skin, other migrant leukocytes, mast cells, and tissue macrophages. Although the epidermis has no direct access to the blood or lymphatic circulation, it is equipped with immune-competent cells: Langerhans cells, the macrophage-like antigen-presenting cells of the epidermis; keratinocytes, epithelial cells with immune properties; dendritic epidermal T lymphocytes, resident cells that may serve as a primitive T-cell immune surveillance system; epidermotropic lymphocytes, migrants from vessels in the dermis; and melanocytes, epidermal pigment cells with immune properties.
Vit C , A and E help the skin. Mouse skin glows and are more shiny with probiotics as reported in one study.

If a certain part of your skin's immune system fails, will it not cause inflammatory reaction to pathogens anymore?