SweGen: A whole-genome map of genetic variability in a cross-section of the Swedish population

Here we describe the SweGen dataset, a high-quality map of genetic variation in the Swedish population. This data represents a basic resource for clinical genetics laboratories as well as for sequencing-based association studies, by providing information on the frequencies of genetic variants in a cohort that is well matched to national patient cohorts.

To select samples for this study, we first examined the genetic structure of the Swedish population using high-density SNP-array data from a nation-wide population based cohort of over 10,000 individuals. From this sample collection, 1,000 individuals, reflecting a cross-section of the population and capturing the main genetic structure, were selected for whole genome sequencing (WGS).

Analysis pipelines were developed for automated alignment, variant calling and quality control of the sequencing data. This resulted in a whole-genome map of aggregated variant frequencies in the Swedish population that we hereby release to the scientific community.

Adam Ameur, Johan Dahlberg, Pall Olason, Francesco Vezzi, Robert Karlsson, Par Lundin, Huiwen Che, JessadaThutkawkorapin, Andreas Kusalananda Kahari, Mats Dahlberg, Johan Viklund, Jonas Hagberg, Niclas Jareborg,Inger Jonasson, Asa Johansson, Sverker Lundin, Daniel Nilsson, Bjorn Nystedt, Patrik Magnusson, Ulf Gyllensten

Published by

connie dello buono

Health educator, author and enterpreneur motherhealth@gmail.com or conniedbuono@gmail.com ; cell 408-854-1883 Helping families in the bay area by providing compassionate and live-in caregivers for homebound bay area seniors. Blogs at www.clubalthea.com Currently writing a self help and self cure ebook to help transform others in their journey to wellness, Healing within, transform inside and out. This is a compilation of topics Connie answered at quora.com and posts in this site.

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.