Why do you need to know your complete DNA sequence?

WGS.JPGAdvantages of Whole Genome Sequencing or complete DNA Sequence test

  • Creating personalized plans to treat disease may be possible based not only on the mutant genes causing a disease, but also other genes in the patient’s genome.
  • Genotyping cancer cells and understanding what genes are misregulated allows physicians to select the best chemotherapy and potentially expose the patient to less toxic treatment since the therapy is tailored.
  • Previously unknown genes may be identified as contributing to a disease state. Traditional genetic testing looks only at the common “troublemaker” genes.
  • Lifestyle or environmental changes that can mediate the effects of genetic predisposition may be identified and then moderated.

Disadvantages of Whole Genome Sequencing

  • The role of most of the genes in the human genome is still unknown or incompletely understood. Therefore, a lot of the “information” found in a human genome sequence is unusable at present.
  • Most physicians are not trained in how to interpret genomic data.
  • An individual’s genome may contain information that they DON’T want to know. For example, a patient has genome sequencing performed to determine the most effective treatment plan for high cholesterol. In the process, researchers discover an unrelated allele that assures a terminal disease with no effective treatment.
  • The volume of information contained in a genome sequence is vast. Policies and security measures to maintain the privacy and safety of this information are still new.

REFERENCES

Ng P and Kirkness E. Whole Genome Sequencing. Methods in Molecular Biology. 2010. 628: 215-226

 

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Published by

connie dello buono

Health educator, author and enterpreneur motherhealth@gmail.com or conniedbuono@gmail.com ; cell 408-854-1883 Helping families in the bay area by providing compassionate and live-in caregivers for homebound bay area seniors. Blogs at www.clubalthea.com Currently writing a self help and self cure ebook to help transform others in their journey to wellness, Healing within, transform inside and out. This is a compilation of topics Connie answered at quora.com and posts in this site.

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