By Dr Lynch

What causes Down Syndrome?

I know you are searching for answers.


Do you have a child with Down Syndrome?

Or do you want to minimize the risk of having a child with Down Syndrome?

Either way, the information here may help.

I want to first state very clearly that there is no ‘defined mainstream way’ to reduce the risk of Down Syndrome except to have your child before the age of 40.

That’s about it.

It is also unacceptable.

Why is it that many, who are far younger than 40 years old, are still having children born with Down Syndrome?

First, let’s discuss some points which will help you if you have a child with Down Syndrome.

If you have a child with Down Syndrome, it is not because you did anything wrong.

It is because you did not have information which may have reduced the risk.

What I am presenting here is absolutely cutting edge information.

I have to share what I know.

My goal is to help. Please keep this in mind.

Last thing I want is you to feel anger or the need to blame someone – including yourself.

I want to empower you and create hope.

I want to create awareness and lasting change.

I want to reduce the known causes which lead to Down Syndrome.

I also want to help those with Down Syndrome.

Health professionals, at least all that I’ve talked with, and I’ve talked with thousands, do not know what causes Down Syndrome.

If health professionals don’t know, then how are you supposed to know?

If you have a child with Down Syndrome, there is a LOT you can do to keep them healthy and vibrant.

Here’s how.

A friend and colleague of mine, Dr Erica Peirson, runs a clinic devoted to children with Down Syndrome.

She’s by far the leading expert out there in Down Syndrome treatment. I encourage you to learn more about how she can help you and your child.

down syndrome treatment

Here are some free Down Syndrome treatment resources to help you and your child with Down Syndrome:


My goal with you right now is to inform you what I believe causes Down Syndrome.

As with any condition or syndrome, there are many contributing factors. There is rarely just one.

Down Syndrome has many contributing factors.

How do we find out what they are?

I believe in research.

The U.S. National Library of Medicine is where I find my information on a daily basis.

I also look at genetic research.

Take a look at which genetic polymorphisms, some of which are very common, are known to cause Down Syndrome:


What is the most researched gene associated with what causes Down Syndrome?


That’s a big deal.

Let’s go a step deeper shall we?

How many of these top 10 researched genes are in the Folate pathway?

Four (4). MTHFR, RFC1, MTHFD1, SLCC19A1

We’re not done yet.

Let’s dig a bit deeper into another key pathway during pregnancy which is shown above to be contributing to Down Syndrome.

The Methylation cycle.


One of my sons has 6 out of 10 of these known genetic polymorphisms which are known to contribute to Down Syndrome.

He is doing very well.

So is it just genetics?

No. Definitely not.

Lifestyle, diet, mindset, environment, nutrition all play a major role here.

What causes Down Syndrome also has to do heavily with the genetics – and epigenetics – of the mother.

Again, it is not just genetics here as genetics are greatly affected by so many things – as mentioned above.

It is known that genetics are affected by lifestyle, environment, infections, diet and nutrition.

If this is the case, and it is, why aren’t health professionals digging into this and educating themselves what causes Down Syndrome??

They’re busy. They don’t have time.

I’ll give them that.

Now it is up to you to share them this article – which they cannot refute.

Here is some of the evidence, 94 published research papers, taken from the U.S. National Library of Medicine, using the term ‘MTHFR Down Syndrome‘:


Let’s get specific.

Breaking it down makes it easier to grasp and show what action must be taken.

A paper published just this month, September 2016, Maternal MTHFR polymorphism (677 C-T) and risk of Down’s syndrome child: meta-analysis, states:

what causes down syndrome

Here is what they found:


Now was it a well done meta-analysis? I think so.


When performing research, one has to limit variables.

It is not possible to have a ton of moving parts in research as that can skew the results. They did what they could.

We mentioned earlier that there are four (4) genes in the Folate Pathway which are heavily studied as a contributor to Down Syndrome.

What is the #1 recommendation for pregnant women across the globe?

Take folic acid.

Here lies the problem.

Folic acid has to bust through many barriers to actually become useful for the body.

These barriers are genes.

Many of these genes have issues.

Down Syndrome research is showing that four key genes in the folate pathway have issues.

What are the issues?

The issues are that the folate genes do not make 100% functional enzymes.

The enzymes produced by dysfunctional genes are slightly defective which slows their ability for one to convert folic acid into active usable folate!

Yet public health and health professionals are recommending folic acid?

They are recommending the very thing that has to bust through barriers in order to support active folate and methylation??

Yet it is known that both folate and methylation dysfunction contribute to Down Syndrome?


Big time.

Take a look:

Folic acid and Down Syndrome


Folic acid has to get through 8 genes in order to become the body’s #1 form of folate which is 5-MTHF.

Did you know that 5-MTHF is now readily available as a supplement?

Did you know that 5-MTHF has been readily available in leafy green vegetables since the dawn of time?

I ask, implore actually:

Why do health professionals and medical organizations recommend folic acid when 5-MTHF is readily available??!

It’s shocking.

There is no reason.

It needs to stop.

If you are looking to understand what causes Down Syndrome, I have actionable information for you:

  1. Don’t use folic acid.
  2. Eat natural folates found in leafy greens
  3. Use prenatal vitamins which have 5-MTHF and other active nutrients
  4. Check your homocysteine level prior to pregnancy and make sure it is around 6 to 10. Too low isn’t good and too high isn’t good.
  5. Read this article on MTHFR and Prenatal Supplementation.

Take a moment, 26 minutes actually, and educate yourself on how bad folic acid is during pregnancy – and what you should use instead.


How do you check to see what your genetics look like?

  1. Order a 23andMe test or Genos Research
  2. Once your results come back, run your raw data through StrateGene.

Here is what one of my son’s StrateGene report looks like – in his Folate Pathway:

MTHFR Genetic Report


As you can see, my son has slow downs in MTHFD1 and MTHFR along with SLC.

My wife did take folic acid during her pregnancies, as we didn’t know at the time it was the wrong thing to do.

She did eat salads often and her homocysteine levels were normal.

This goes to show you that even with genetic issues in key pathways, one can lead a ‘normal’ life.

The key here is to understand that one may have increased susceptibilities and this increases the need to take precautions.

Genetic testing is empowering. At least it should be.

Another key point is my wife does not have the MTHFR C677T homozygous genetic polymorphism.


Remember, many research papers are evaluating the genetics of the woman.

This is very important and why I greatly emphasize the need to prepare the future mother prior to pregnancy.

Need more information on how folic acid is harmful?

Do you want to see the science behind it?

I’ve created a free one hour research-supported presentation:


I hope this has served you well.

There is a lot of information to wade through here. Take your time with it.

What is presented here strongly informs us all what causes Down Syndrome.

The key is to share this empowering information to your health professional.

Let’s optimize pregnancies.

I believe we can.

Let’s also improve the lives of those with Down Syndrome.

We can do that, too.

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