Yoga and behavioral memory interventions to prevent age-related cognitive decline

A study examined changes in brain metabolites and structure among individuals undergoing memory training and yogic meditation. We demonstrated that memory training over 3 months is associated with decreased choline levels in bilateral hippocampus and increased gray-matter volume in dACC, suggesting that behavioral interventions like MET may ameliorate markers of brain aging. These effects are somewhat modest, and would benefit from independent validation in larger samples and perhaps over longer-duration interventions. However, these findings suggest that engaging in cognitive activities and mind-body practices may affect the brain in positive ways, and may be combined as part of a multi-faceted approach to encourage healthy aging.

Behavioral memory training is also popular, based on the notion that cognition is plastic in older age (Acevedo and Loewenstein, 2007; Eyre et al., 2016). For example, traditional memory training interventions that teach mnemonic techniques involving verbal association and visual imagery and practical strategies have been shown to boost cognitive performance, memory, and quality of life in healthy older adults (Verhaeghen et al., 1992; Jean et al., 2010). Given the growing popularity of online “Brain Training” programs, clearer understanding of behavioral memory training programs already demonstrated to be effective in the clinic is needed.

In recent years, mind-body therapies have also been studied as potential preventive measures for MCI (Grossman et al., 2004). By simultaneously targeting multiple physiological and cognitive processes, as well as their dynamic integration, meditation may offer a more efficient alternative to other behavioral interventions. Indeed, some studies indicate that senior meditators have better memory, perceptual speed, attention and executive functioning compared with non-meditators (Prakash et al., 2012), though results are mixed (Chiesa et al., 2011; Goyal et al., 2014). A combination of Kirtan Kriya (KK) meditation and Kundalini Yoga (KY), as used as an intervention in the current study, is specifically shown to affect physical and mental health outcomes (Shannahoff-Khalsa, 2004; Krisanaprakornkit et al., 2006), including older adults with memory complaints (Moss et al., 2012). Like other forms of mind-body practice, KY and KK have been demonstrated to benefit cognitive function, depressed mood and anxiety, sleep and coping (Black et al., 2013; Lavretsky et al., 2013), including older adults with cognitive impairments (Newberg et al., 2010).

Role of Anterior Cingulate Cortex in Cognitive Aging

In our study, we provide novel evidence that a behavioral memory intervention (MET) can modestly increase cortical gray matter in dACC, a region of the brain linked to multiple key cognitive functions, such as error detection (Gehring et al., 1993), and executive processing (Carter et al., 2000). Gray-matter volume has been demonstrated to decrease with age in the ACC in both cross-sectional (Sowell et al., 2003) and longitudinal studies (Resnick et al., 2003). Correspondingly, age is negatively correlated with blood flow in dorsal and rostral ACC regions (Vaidya et al., 2007). Seniors who engage more in cognitive games and puzzles in their daily lives also tend to have greater ACC gray matter volume (Schultz et al., 2015), which is consistent with our results and raises the possibility that engaging in cognitive-behavioral games or training could prevent age-related structural atrophy in this region. Indeed, a recent study indicated a trend towards increased rostral ACC thickness in seniors after MET; however, this effect did not survive a stringent validation analysis (Engvig et al., 2010). Although our effects are modest, they do indicate that participating in effective behavioral interventions may help to ameliorate age-related brain changes associated with poor memory and cognitive performance.

Yoga and the Aging Brain

Structural plasticity in the dACC and hippocampus has also been associated with yoga practice in previous studies; however, we did not find evidence of gray-matter volume changes in dACC or hippocampus after our 12-week yoga intervention. Yoga has been linked to anatomical changes in frontal cortex (Baijal and Srinivasan, 2010; Froeliger et al., 2012; Villemure et al., 2014; Desai et al., 2015), anterior cingulate cortex (ACC) and insula (Nakata et al., 2014; Villemure et al., 2014, 2015), and the hippocampus (Froeliger et al., 2012; Villemure et al., 2015). However, many of these studies compare the brains of practiced yogis with several months or years of experience to yoga-naive controls (Froeliger et al., 2012); perhaps the relatively shorter length of training in the current study (12 weeks) was less conducive to detecting structural plasticity associated with our yoga intervention. In this same cohort, we have already demonstrated that memory improvements after yoga and MET may induce functional plasticity in similar brain regions (Eyre et al., 2016).

http://journal.frontiersin.org/article/10.3389/fnagi.2016.00277/full