Maternal Depression Across Child’s Early Years Impacts Neural Basis of Empathy

Summary: Children whose mothers experienced depression early in their life are more susceptable to socio-emotional problems and a reduction in empathy toward others, a new study reports.

Source: Elsevier.

Exposure to early and chronic maternal depression markedly increases a child’s susceptibility to psychopathology and social-emotional problems, including social withdrawal, poor emotion regulation, and reduced empathy to others. Since 15-18% of women in industrial societies and up to 30% in developing countries suffer from maternal depression, it is of clinical and public health concern to understand the effects of maternal depression on children’s development. A study published in the January 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) followed children of mothers with depression from birth to preadolescence and tested depression’s impact on children’s neural empathic response to others’ distress.

While previous studies have demonstrated the effects of maternal depression on children’s limited response to other’s pain, this new study is the first to examine this topic in a longitudinal sample of mother-child pairs followed from birth to age 11. This carefully selected sample of women with no comorbid contextual risk, who were repeatedly assessed for maternal depression across the first years of life, was utilized in order to compare children of mothers who were chronically depressed and children who were never exposed to any maternal psychopathology. 27 children of mothers with depression took part in the study, as well as 45 controls. They were home-visited at 9 months and 6 years to examine mother-child interaction patterns and were invited to a magnetoencephalography (MEG) session at age 11 in order to evaluate their neural reaction to pain in others.

“We were amazed to see that maternal depression in and of itself was related to differential neural processing of others’ pain in 11-year-old children. We found that the neural reaction to pain in children of depressed mothers stops earlier than in controls, in an area related to socio-cognitive processing, so that children of depressed mothers seem to reduce mentalizing-related processing of others’ pain, perhaps because of difficulty in regulating the high arousal associated with observing distress in others,” said Prof. Ruth Feldman, director of the Developmental Social Neuroscience Lab and the Irving B. Harris Early Childhood Community Clinic at Bar-Ilan University and lead author of the study.

The researchers also found that mother-child interaction patterns had a crucial role on this effect. When mother-child interactions were more synchronous, that is, mother and child were better attuned to one another, and when mothers were less intrusive, children showed higher mentalizing-related processing in this crucial brain area.

Image shows a crying woman.

“It is encouraging to see the role of mother-child interactions in our findings. Depressed mothers are repeatedly found to show less synchronous and more intrusive interactions with their children, and so it might explain some of the differences found between children of depressed mothers and their peer controls in our study,” added Prof. Feldman. “If so, our findings highlight a point of entry, where future interventions can focus their attention to help reduce the effects of maternal depression on children’s psychosocial development.”

Asked what next steps should be taken, Feldman responded: “The main clinical question now becomes: what strategies are most effective to improve mother-child interaction patterns for depressed mothers and their offspring. Moreover, if we are able to help these mothers be more attuned and less intrusive, will it be enough in order to enable resilience in the offspring? In addition, there are further scientific questions about the manner in which patterns of maternal care implement in the development of children’s brain, endocrine systems, behavior, and relationships.”

To that end, Feldman and her team are studying how maternal depression and mother-child interactions are associated with children’s stress hormones, behavioral empathy, hormones related to bond formation, and their neural reaction to affiliative cues. Feldman is planning to study intervention strategies that focus on the mother-child interaction pattern, and is hopeful that if successful, these strategies will improve mental health and social adjustment in children of mothers with depression. “Wouldn’t it be interesting and promising if an intervention focused on synchronous mother-child interactions could also reduce the prevalence of psychopathology in the children of depressed mothers?” she concluded.

ABOUT THIS GENETICS RESEARCH ARTICLE

Source: Mary Billingsley – Elsevier
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Maternal Depression Across the First Years of Life Impacts the Neural Basis of Empathy in Preadolescence” by Maayan Pratt, MA, Abraham Goldstein, PhD, Jonathan Levy, PhD, Ruth Feldman, PhD in Journal of American Academy of Child and Adolescent Psychiatry. Published online January 3 2017 doi:10.1016/j.jaac.2016.10.012

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Elsevier “Maternal Depression Across Child’s Early Years Impacts Neural Basis of Empathy.” NeuroscienceNews. NeuroscienceNews, 3 January 2017.
<http://neurosciencenews.com/maternal-depression-empathy-children-5851/>.

Abstract

Maternal Depression Across the First Years of Life Impacts the Neural Basis of Empathy in Preadolescence

Objective
Exposure to maternal depression across the first years of life markedly increases children’s susceptibility to psychopathology, yet no study has tested its effects on the maturation of children’s social brain.

Method
Using a birth cohort of mothers with no contextual risk (N = 1,983), families were followed at 7 time points from birth to 11 years and repeatedly assessed for maternal depression across the first 6 years to form 2 cohorts: mothers continuously depressed from birth to 6 years and controls without depression. At 11 years of age, children’s (n = 72; depressed, n = 27; nondepressed, n = 45) brain response to others’ pain was measured by magnetoencephalography.

Results
Preadolescents displayed a unique oscillatory pattern with higher alpha power to pain versus no pain expressing as alpha rebound, not alpha suppression, at a late time window (1,100–1,300 ms post-stimulus) in the supplementary motor area. This suggests that top-down processing in areas of the pain matrix can underpin the maturation of vicarious empathy. Children of mothers with depression showed enhanced alpha rebound to pain in the right posterior superior temporal gyrus, which was unrelated to emotion detection abilities, pointing to decreased late processing of others’ overwhelming experiences in socio-cognitive areas. Alpha power in the posterior superior temporal gyrus was predicted by higher maternal intrusiveness and lower synchrony across early childhood.

Conclusion
These findings, from the first study to examine maternal depression and early caregiving as long-term predictors of children’s neural empathic response, pinpoint a decrease in top-down socio-cognitive mechanisms as potential pathways for the cross-generational transfer of vulnerability from mothers with depression to their offspring and highlight the need for early interventions focused on enhancing maternal attunement.

“Maternal Depression Across the First Years of Life Impacts the Neural Basis of Empathy in Preadolescence” by Maayan Pratt, MA, Abraham Goldstein, PhD, Jonathan Levy, PhD, Ruth Feldman, PhD in Journal of American Academy of Child and Adolescent Psychiatry. Published online January 3 2017 doi:10.1016/j.jaac.2016.10.012

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