My answer to Why does Prednisone cause depression?
Answer by Connie b. Dellobuono:
Prednisone weakens the immune system. Do a slow withdrawal.
suppression will begin to occur if prednisone is taken for longer than seven days. Eventually, this may cause the body to temporarily lose the ability to manufacture natural corticosteroids (especially cortisol), which results in dependence on prednisone. For this reason, prednisone should not be abruptly stopped if taken for more than seven days; instead, the dosage should be gradually reduced. This weaning process may be over a few days, if the course of prednisone was short, but may take weeks or months
if the patient had been on long-term treatment. Abrupt withdrawal may lead to an. For those on chronic therapy, alternate-day dosing may preserve adrenal function and thereby reduce side effects.
Glucocorticoids act to inhibit feedback of both the, decreasing [CRH], and in the gland, decreasing the amount of [ACTH]. For this reason, glucocorticoid analogue drugs such as prednisone down-regulate the natural synthesis of glucocorticoids. This mechanism leads to dependence in a short time and can be dangerous if medications are withdrawn too quickly. The body must have time to begin synthesis of CRH and ACTH and for the adrenal glands to begin functioning normally again.
Dr Mercola wrote natural ways to avoid prednisone:
- Eliminatingfrom the diet
- Increasing, primarily EPA and DHA
- Removing anyfrom the system