Is dementia related to all anti-cholinergics or just GABA-enhancing ones?

My answer to Is dementia related to all anti-cholinergics or just GABA-enhancing ones?

Answer by Connie b. Dellobuono:

To both and many neuro drugs including narcotics (tramadol,others).

These Sleep and Anxiety Drugs May Cause Dementia: Benzodiazepines – the chief inhibitory neurotransmitter in the brain and its effects counteracts the actions of stimulants and excitatory neurotransmitters such as epinephrine

Medications to avoid or use briefly; Common drugs that might increase dementia risk ;

Two types of drugs you may want to avoid for the sake of your brain – Harvard Health

Possible alternatives

Allergies, colds

Anticholinergics

brompheniramine (Dimetapp)

carbinoxamine (Palgic)

chlorpheniramine (Chlor-Trimeton)

diphenhydramine (Benadryl)

hydroxyzine (Atarax, Vistaril)

cetirizine (Zyrtec)

desloratadine (Clarinex)

fexofenadine (Allegra)

loratadine (Claritin)

Anxiety

Benzodiazepines

alprazolam (Xanax)

chlordiazepoxide (Librium)

clonazepam (Klonopin)

clorazepate (Tranxene)

diazepam (Valium)

flurazepam (Dalmane)

lorazepam (Ativan)

oxazepam (Serax)

bupropion (Wellbutrin)

buspirone (Buspar)

citalopram (Celexa)

fluoxetine (Prozac)

paroxetine (Paxil)

sertraline (Zoloft)

venlafaxine (Effexor)

Depression

Anticholinergics

amitriptyline (Elavil)

clomipramine (Anafranil)

doxepin (Sinequan)

imipramine (Tofranil)

trimipramine (Surmontil)

bupropion (Wellbutrin)

buspirone (Buspar)

citalopram (Celexa)

fluoxetine (Prozac)

paroxetine (Paxil)

sertraline (Zoloft)

venlafaxine (Effexor)

Insomnia

Anticholinergics

mirtazapine (Remeron)

nefazodone (Serzone)

trazodone (Desyrel)

Benzodiazepines

estazolam (Prosom)

quazepam (Doral)

temazepam (Restoril)

triazolam (Halcion)

Melatonin

Nondrug approaches

practicing relaxation techniques

avoiding alcohol and heavy meals before bedtime

exercising vigorously early in the day

Urge incontinence

Anticholinergics

darifenacin (Enablex)

fesoterodine (Toviaz)

flavoxate (Urispas)

oxybutynin (Ditropan)

solifenacin (Vesicare)

tolterodine (Detrol)

trimipramine (Surmontil)

trospium (Sanctura)

Nondrug approaches

bladder training

physical exercise

weight loss for overweight or obese women

Minimally invasive procedures

Botox injections

implantable bladder stimulators

Possible effects of anticholinergics include:

Sources: DeGage SB, et al. “Benzodiazepine use and risk of Alzheimer’s disease: Case-control study,” BMJ (Sept. 9, 2014), Vol. 351, published online; Salahudeen MS et al. “Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: A systematic review,” BMC Geriatrics (March 15, 2015), Vol.15, No.31, published online.

Is dementia related to all anti-cholinergics or just GABA-enhancing ones?

Leave a Reply

This site uses Akismet to reduce spam. Learn how your comment data is processed.