Source: Dartmouth College.
Study refutes theory that behavior under uncertainty is optimal.
Each time we get feedback, the brain is hard at work updating its knowledge and behavior in response to changes in the environment; yet, if there’s uncertainty or volatility in the environment, the entire process must be adjusted. A Dartmouth-led study published in Neuron reveals that there’s not a single rate of learning for everything we do, as the brain can self-adjust its learning rates using a synaptic mechanism called metaplasticity.
The findings refute the theory that the brain always behaves optimally. How the brain adjusts learning, has long been thought to be driven by the brain’s reward system and its goal of optimizing rewards obtained from the environment or by a more cognitive system responsible for learning the structure of the environment.
Synapses are the connections between neurons in the brain and are responsible for transferring information from one neuron to the next. When it comes to choice in evaluating potential rewards, your learned value of a particular option, reflecting how much you like something, is stored in certain synapses. If you get positive feedback after choosing a particular option, the brain increases the value of that option by making the associated synapses stronger. In contrast, if the feedback is negative, those synapses become weaker. Synapses, however, can also undergo modifications without changing how they transmit information through a process called metaplasticity.
Previous studies have suggested that the brain relies on a dedicated system for monitoring the uncertainty in the environment to adjust its rate of learning. The authors of this study found however, that metaplasticity alone is sufficient to fine-tune learning according to the uncertainty about reward in a given environment.
“One of the most complex problems in learning is how to adjust to uncertainty and the rapid changes that take place in the environment. It is very exciting to find that synapses, the simplest computational elements in the brain, can provide a robust solution for such challenges,” says Alireza Soltani, assistant professor of psychological and brain sciences at Dartmouth. “Of course, such simple elements may not provide an optimal solution but we found that a model based on metaplasticity can explain real behaviors better than models that are based on optimality,” he added.
To understand the neural mechanisms for adjusting learning, more specifically, how learning and choice are impacted by reward uncertainty and volatility in an environment, the researchers created a model based on metaplasticity. They tested this model against a behavioral dataset from a recent Yale University study of non-human primates in which the probabilities of obtaining a reward were switched to create environments with different levels of volatility. When things change frequently, a large learning rate is required but this reduces precision, whereas, a stable environment requires a small learning rate, which improves precision. The study illustrates how metaplasticity can mitigate the tradeoff between adaptability and precision in learning.
The metaplasticity model also demonstrates how the learning rate might be different for each choice or option. If a particular choice continues to give reward for a while, the learning rate on that option becomes larger for rewarding outcomes and smaller for non-rewarding outcomes. That is, if the environment does not change, the synapses needed for changing the preferences become less sensitive to feedback in the opposite direction. In addition, the model also predicts that different options or actions could maintain their own learning rates.
This study demonstrates that learning can be self-adjusted and does not require explicit optimization or complete knowledge of the environment. The authors propose potential practical implications of their findings. The brain’s inability to modify its behavior may be attributed to the slowing down of plasticity due to metaplasticity, which can occur in a highly stable environment. For behavioral anomalies such as addiction, where the synapses might not adapt flexibly, more carefully designed feedback may be required to make the system plastic again, illustrating how metaplasticity may have broader relevance.
Source: Amy D. Olson – Dartmouth College
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Metaplasticity as a Neural Substrate for Adaptive Learning and Choice under Uncertainty” by Shiva Farashahi, Christopher H. Donahue, Peyman Khorsand, Hyojung Seo, Daeyeol Lee, and Alireza Soltani in Neuron. Published online April 19 2017 doi:10.1016/j.neuron.2017.03.044
Metaplasticity as a Neural Substrate for Adaptive Learning and Choice under Uncertainty
•Metaplasticity can adjust learning according to reward uncertainty
•Learning is adjusted without knowledge of the environment or explicit optimization
•Metaplasticity model predicts choice behavior more accurately than optimal models
•Changes in the activity of model neurons can be used to estimate uncertainty
Value-based decision making often involves integration of reward outcomes over time, but this becomes considerably more challenging if reward assignments on alternative options are probabilistic and non-stationary. Despite the existence of various models for optimally integrating reward under uncertainty, the underlying neural mechanisms are still unknown.
Here we propose that reward-dependent metaplasticity (RDMP) can provide a plausible mechanism for both integration of reward under uncertainty and estimation of uncertainty itself.
We show that a model based on RDMP can robustly perform the probabilistic reversal learning task via dynamic adjustment of learning based on reward feedback, while changes in its activity signal unexpected uncertainty.
The model predicts time-dependent and choice-specific learning rates that strongly depend on reward history. Key predictions from this model were confirmed with behavioral data from non-human primates.
Overall, our results suggest that metaplasticity can provide a neural substrate for adaptive learning and choice under uncertainty.
“Metaplasticity as a Neural Substrate for Adaptive Learning and Choice under Uncertainty” by Shiva Farashahi, Christopher H. Donahue, Peyman Khorsand, Hyojung Seo, Daeyeol Lee, and Alireza Soltani in Neuron. Published online April 19 2017 doi:10.1016/j.neuron.2017.03.044