NIH: Enzyme drives middle-age weight and fitness changes

Construction worker holding ears

Protein involved in hearing loss recovery

A study with mice found that a protein called FOXO3 is involved in recovery from noise-induced hearing loss. The results suggest new potential treatments approaches.


Illustration of mitochondria

Enzyme drives middle-age weight and fitness changes

Scientists identified an enzyme in animal studies whose activity promotes weight gain and the loss of fitness starting in mid-life. The findings could lead to improved weight-loss drugs.


Fused forebrain spheroids

3-D model of human brain development and disease

A 3-D brain development model revealed a defect in how neurons migrate to cause Timothy syndrome. The results demonstrate a way to study personalized brain development and disease.


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