Iron overload, organs affected and related health issues

Organs commonly affected by haemochromatosis are the liver, heart, and endocrine glands.[3]

Haemochromatosis may present with the following clinical syndromes:[4]

  • Cirrhosis of the liver: Varies from zonal iron deposition[5] to fibrosis (cirrhosis).
  • Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death.[2][6]
  • Cardiomyopathy
  • Arthritis, from calcium pyrophosphate deposition in joints. The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers.[7]
  • Testicular failure
  • Bronzing of the skin. This deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: “bronze diabetes”.
  • Joint pain and bone pain

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connie dello buono

Health educator, author and enterpreneur or ; cell 408-854-1883 Helping families in the bay area by providing compassionate and live-in caregivers for homebound bay area seniors. Blogs at Currently writing a self help and self cure ebook to help transform others in their journey to wellness, Healing within, transform inside and out. This is a compilation of topics Connie answered at and posts in this site.

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