NO Promotes Healthy Heart and Brain Function
In one recent study,7,8,9,10 patients diagnosed with high blood pressure who drank beet juice an hour before exercise, three times a week for six weeks, experienced increased tissue oxygenation and blood flow. It also improved brain neuroplasticity by improving oxygenation of the somatomotor cortex (a brain area that is often affected in the early stages of dementia).
As noted by study co-author W. Jack Rejeski, a health and exercise science professor at Wake Forest University in North Carolina, NO is a vital biomolecule that “goes to the areas of the body which are hypoxic, or needing oxygen, and the brain is a heavy feeder of oxygen in your body.”11,12 Your heart, too, requires NO and oxygen for optimal function. As noted by cardiologist Dr. Stephen Sinatra:13
“Adequate NO production is the first step in a chain reaction that promotes healthy cardiovascular function, while insufficient NO triggers a cascade of destruction that eventually results in heart disease… NO promotes healthy dilation of the veins and arteries so blood can move throughout your body. Plus, it prevents red blood cells from sticking together to create dangerous clots and blockages.”
Which Foods Contain the Most Nitrates?
As noted by Greger in the featured video, leafy greens top the list of nitrate-rich foods. Beets, which are a root vegetable, are well-known for their high nitrate content, but leafy greens contain even more nitrates per serving. In fact, beets barely made it onto the top 10 list, which is as follows:
|1. Arugula, 480 mg of nitrates per 100 grams||2. Rhubarb, 281 mg|
|3. Cilantro, 247 mg||4. Butter leaf lettuce, 200 mg|
|5. Spring greens like mesclun mix, 188 mg||6. Basil, 183 mg|
|7. Beet greens, 177 mg||8. Oak leaf lettuce, 155 mg|
|9. Swiss chard, 151 mg||10. Red beets, 110 mg|
Arugula, in the No. 1 spot, contains more nitrates than any other vegetable, and by a wide margin too — 480 mg per 100 grams. The second-highest source, rhubarb, contains about 280 mg per 100 grams, which is about the same amount found in a 100-gram serving of beet root juice, whereas 100 grams of whole red beets provide a mere 110 mg of nitrates.
Other foods high in nitrates include the following.14,15,16 (While garlic is low in nitrates, it helps boost NO production by increasing NOS, which converts L-arginine to NO in the presence of cofactors such as vitamins B2 and B3.17)
|Source||Mg of nitrates per 100 grams|
|Bok choy||70 to 95 mg|
|Carrots||92 to 195 mg|
|Mustard greens||70 to 95 mg|
|Spinach||24 to 387 mg|
|Chinese cabbage||43 to 161 mg|
|Winter melon||16 to 136 mg|
|Eggplant||25 to 42 mg|
|Parsley||100 to 250 mg|
|Leeks||100 to 250 mg|
|Turnips||50 to 100 mg|
|Cauliflower||20 to 50 mg|
|Broccoli||20 to 50 mg|
|Artichoke||Less than 20 mg|
|Garlic||Less than 20 mg|
|Onion||Less than 20 mg|
Nitrate-Rich Foods Protect Against Heart Disease
Previous research has shown that the more vegetables and fresh fruits you eat, the lower your risk of heart disease, with leafy greens being the most protective. As noted by Greger, the reason for this is likely their NO-boosting nitrates. This was confirmed in a May 2017 study published in The American Journal of Clinical Nutrition.18
In this study, nearly 1,230 Australian seniors without atherosclerotic vascular disease (ASVD) or diabetes were followed for 15 years. A food-frequency questionnaire was used to evaluate food intake, while nitrate intake was calculated using a comprehensive food database. As expected, the higher an individual’s vegetable nitrate intake, the lower their risk for both ASVD and all-cause mortality. According to the authors:
“Nitrate intake from vegetables was inversely associated with ASVD mortality independent of lifestyle and cardiovascular disease risk factors in this population of older adult women without prevalent ASVD or diabetes. These results support the concept that nitrate-rich vegetables may reduce the risk of age-related ASVD mortality.”
Leafy Greens and Sports Performance
Most competitive athletes understand the value of NO, and the wise ones take advantage of Mother Nature’s bounty. While research19,20has shown nitrate supplements can boost sports performance and enhance fast-twitch muscle fibers, you can get the same results using whole foods. For example, research shows raw beets can increase exercise stamina by as much as 16 percent,21 an effect attributed to increased NO.
In another study,22 nine patients diagnosed with heart failure who experienced loss of muscle strength and reduced ability to exercise were found to benefit from beet juice. The patients were given 140 milliliters (mL) — about two-thirds of a cup — of concentrated beet juice, followed by testing, which found an almost instantaneous increase in their muscle capacity by an average of 13 percent.
There’s one important caveat though: Avoid using mouthwashes or chewing gum, as this actually prevents the NO conversion from occurring.23 The reason for this is because the nitrate is converted into nitrite in your saliva by friendly bacteria. That nitrite is then converted into NO in other places in your body.
More Information About NO
NO24 — not to be confused with nitrous oxide, commonly known as laughing gas, a chemical compound with the formula N2O25 — serves as a signaling or messenger molecule in every cell of your body. Hence, it’s involved in a wide variety of physiological and pathological processes. As mentioned, it causes arteries and bronchioles to expand, but it’s also needed for communication between brain cells, and causes immune cells to kill bacteria and cancer cells.
Now, your body loses about 10 percent of its ability to make NO for every decade of life, which is why eating a nitrate-rich diet is so important. NO is further synthesized by nitric oxide synthase (NOS). There are three isoforms of the NOS enzyme:
- Endothelial (eNOS): a calcium-dependent signaling molecule that produces low levels of gas as a cell signaling molecule
- Neuronal (nNOS): a calcium-dependent signaling molecule that produces low levels of gas as a cell signaling molecule
- Inducible (immune system) (iNOS): calcium independent; produces large amounts of gas, which can be cytotoxic
Problematically, when fluoride is present (such as when you’re drinking fluoridated water), the fluoride converts NO into the toxic and destructive nitric acid. As noted in “Pharmacology for Anesthetists 3,”26 “[NO] will react with fluorine, chlorine and bromine to form the XNO species, known as the nitrosyl halides, such as nitrosyl chloride.” Hence, avoiding fluoridated water and other halide sources, such as brominated flour, is important to optimize your health and avoid damaging interactions.
Exercise Also Boosts NO Production
Aside from eating a nitrate-rich diet, one efficient way to increase NO production is a series of callisthenic exercises. I’m using a modified version of a routine originally developed by Dr. Zach Bush. You’ll find a quick demonstration of my “Nitric Oxide Dump” routine in the video above. This routine takes about three to four minutes and is ideally done three times a day, at least two hours apart.