Brain Structure Makes Some Resilient to Alzheimer’s

Summary: According to researchers, the size, shape and number of dendritic spines in the brain may determine whether a person develops Alzheimer’s disease.

Source: University of Alabama at Birmingham.

The size, shape and number of dendritic spines in the brain may play a major role in whether someone gets Alzheimer’s disease, according to new research from the University of Alabama at Birmingham. Dendritic spines are sub-units of neurons that act as the connector to other neurons.

In findings published Oct. 24 in the Annals of Neurology, the research team showed, for the first time, that the presence of healthy dendritic spines conveyed a protective effect against Alzheimer’s in people whose brains had proteins associated with the disease.

“One of the precursors of Alzheimer’s is the development in the brain of proteins called amyloid and tau, which we refer to as the pathology of Alzheimer’s,” said Jeremy Herskowitz, Ph.D., assistant professor in the Department of Neurology, School of Medicine and lead author of the study. “However, about 30 percent of the aging population have amyloid and tau buildup but never develop dementia. Our study showed that these individuals had larger, more numerous dendritic spines than those with dementia, indicating that spine health plays a major role in the onset of disease.”

Neurons are constantly sending out long, thin dendritic spines in search of other neurons. When they connect, a synapse, or exchange of information between neurons, occurs. This is the basis for memory and learning.

“One obvious culprit in Alzheimer’s disease is the loss of dendritic spines and thus the loss of synapses,” said Herskowitz, who is the Patsy W. and Charles A. Collat Scholar in Neuroscience. “This would impair the ability to think, so the assumption has been that those without dementia had healthy spines and those with dementia did not. But no one had gone in to see if that was true.”

Herskowitz’s team studied brain samples from patients at memory clinics at Emory University. The control group did not have the Alzheimer’s pathology of amyloid plaques and tau tangles and never developed dementia. A second group had the Alzheimer’s pathology and progressed to the disease. The third group had the pathology, but no disease.

The researchers took thousands of microscopy images of the subject brains. Those images were then turned into 3-D images using novel, exclusive software. This allowed the team to look more fully at the shape and dimensions of each image.

“We first noted that the control group had more dendritic spines than the group with Alzheimer’s, which matched beautifully with existing historical data,” Herskowitz said. “But we also saw that the group with Alzheimer’s pathology but no disease also had more spines than the Alzheimer’s group. In fact, they had roughly the same spine density as the control group. What is even more exciting is that the ‘pathology but no disease’ group had very long spines, longer than both the control group and the disease group.”

Image shows neurons.

Herskowitz says the longer spines demonstrated great plasticity, or ability to move. This indicates that they could navigate around or through amyloid plaques or tau tangles in their efforts to connect with other neurons.

“This provides an explanation of why some people are cognitively resilient to Alzheimer’s disease, even if they possess the typical Alzheimer’s pathology,” he said.

Herskowitz says that the high plasticity and density of dendritic spines in this population could be genetic. Another theory suggests that it could be the result of healthy lifestyle behaviors, such as good diet and exercise, which are known to be protective against dementia. It may be that the reason these behaviors are protective is that they help maintain spine health, plasticity and density.

The findings also offer a new target for slowing or preventing Alzheimer’s in the first place, Herskowitz says.

“This provides a target for drugs that would be designed to support and maintain dendritic spine health in an effort to rebuild neurons or prevent their loss,” he said. “This data suggests that rebuilding neurons is possible. And as we are better able to identify the increase of amyloid and tau early in the progression of the disease, even before symptoms arise, we might be able to one day offer a medication that can contribute to maintaining healthy dendritic spines in those with the Alzheimer’s pathology.”


Funding: Herskowitz credits the innovative 3-D imaging system used in the study to groundbreaking work done by UAB science and technology honors student Benjamin Boros. Funding for the study was provided by the National Institute on Aging, part of the National Institutes of Health, and the Alzheimer’s Association.

Source: Bob Shepard – University of Alabama at Birmingham
Publisher: Organized by
Image Source: image is credited to Alzheimer’s disease group.
Original Research:Abstract for “Dendritic spines provide cognitive resilience against Alzheimer’s disease” by Benjamin D. Boros, Kelsey M. Greathouse BS, Erik G. Gentry BS, Kendall A. Curtis, Elizabeth L. Birchall BS, Marla Gearing PhD, and Jeremy H. Herskowitz PhD in Annals of Neurology. Published online October 22 2017 doi:10.1002/ana.25049

University of Alabama at Birmingham “Brain Structure Makes Some Resilient to Alzheimer’s.” NeuroscienceNews. NeuroscienceNews, 24 October 2017.


Dendritic spines provide cognitive resilience against Alzheimer’s disease


Neuroimaging and other biomarker assays suggest that the pathological processes of Alzheimer’s disease (AD) begin years prior to clinical dementia onset. However, some 30 to 50% of older individuals who harbor AD pathology do not become symptomatic in their lifetime. It is hypothesized that such individuals exhibit cognitive resilience that protects against AD dementia. We hypothesized that in cases with AD pathology, structural changes in dendritic spines would distinguish individuals who had or did not have clinical dementia.


We compared dendritic spines within layer II and III pyramidal neuron dendrites in Brodmann area 46 dorsolateral prefrontal cortex using the Golgi–Cox technique in 12 age-matched pathology-free controls, 8 controls with AD pathology (CAD), and 21 AD cases. We used highly optimized methods to trace impregnated dendrites from bright-field microscopy images that enabled accurate 3-dimensional digital reconstruction of dendritic structure for morphologic analyses.


Spine density was similar among control and CAD cases but was reduced significantly in AD. Thin and mushroom spines were reduced significantly in AD compared to CAD brains, whereas stubby spine density was decreased significantly in CAD and AD compared to controls. Increased spine extent distinguished CAD cases from controls and AD. Linear regression analysis of all cases indicated that spine density was not associated with neuritic plaque score but did display negative correlation with Braak staging.


These observations provide cellular evidence to support the hypothesis that dendritic spine plasticity is a mechanism of cognitive resilience that protects older individuals with AD pathology from developing dementia.

“Dendritic spines provide cognitive resilience against Alzheimer’s disease” by Benjamin D. Boros, Kelsey M. Greathouse BS, Erik G. Gentry BS, Kendall A. Curtis, Elizabeth L. Birchall BS, Marla Gearing PhD, and Jeremy H. Herskowitz PhD in Annals of Neurology. Published online October 22 2017 doi:10.1002/ana.25049

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