Zinc jams shut a protein transporter in bacteria preventing infection this winter

After delivering babies, mothers would feed a young mother with soup from clams, spinach, garlic, mushrooms, onions. This soup is rich in zinc and other flavones that can kill bacteria, virus and infection. This coming winter season, more seniors get hospitalized from pneumonia. So fill your kitchen storage with onions, garlic, mushrooms, seeds, nuts, citrus fruits , herbs (turmeric, curcumin, tyme,sage) and other zinc-rich foods.

If you have no time to prepare most of the above foods and wanted to supplement, I suggest anti-inflammatory supplements (Lifepak and AGELOC family) at :

http://www.clubalthea.pxproducts.com

Zinc jams shut a protein transporter in bacteria

Published today in the journal Nature Chemical Biology, the researchers describe how zinc “jams shut” a protein transporter in the bacteria so that it cannot take up manganese, an essential metal that Streptococcus pneumoniae needs to be able to invade and cause disease in humans.

zinc

 

Flavones block the actions of leukotrienes

Inhibition of the 5-lipoxygenase pathway

Some chemicals found in trace amounts in food, and some dietary supplements, also have been shown in inhibit 5-LOX, such as baicalein, caffeic acid, curcumin, hyperforin and St John’s wort (contra-indicated when you are taking antibiotics, other meds).

  1. https://en.wikipedia.org/wiki/BaicaleinBaicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also …

  2. http://www.jbc.org/content/279/26/26846.fullJun 25, 2004  Baicalein is a flavonoid with antioxidant properties; upon oxidation, it forms several products including quinones. We show here that low …

  3. https://www.ncbi.nlm.nih.gov/pubmed/17976269J Pharm Pharmacol. 2007 Nov;59(11):1567-72. Scutellaria baicalensis and a constituent flavonoidbaicalein, attenuate ritonavir-induced gastrointestinal …

  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2573395/Aug 23, 2008  The flavonoid baicalein inhibits fibrillation of α-synuclein, which is a major component of the Lewy bodies in Parkinson’s disease. It has been …

  5. https://selfhacked.com/blog/baicalein-baicalin-top-7-health-benefits-flavanoid/3 days ago  Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis and Scutellaria lateriflora that …

  6. http://journal.frontiersin.org/article/212440Aug 29, 2016  A commentary on. The Flavonoid Baicalein Rescues Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer’s Disease

  7. https://www.hindawi.com/journals/ecam/2013/635694/Jun 10, 2013  The estrogenic activity of two flavonoidsbaicalein and daidzein, were demonstrated by their strong abilities in stimulating estrogen receptor …

  8. http://pubs.acs.org/doi/abs/10.1021/acs.biochem.6b00578Jul 19, 2016  Amyloid formation of the 37-residue amylin is involved in the pathogenesis of type 2 diabetes and potentially, diabetes-induced neurological …

  9. http://www.sciencedirect.com/science/article/pii/S0304383510002375Nov 1, 2010  Baicalein is a flavonoid derived from the root of Scutellaria baicalensis, widely used in Chinese herbal medicine. Historically, S. baicalensis has …

  10. http://www.sciencedirect.com/science/article/pii/S0166432816303369May 24, 2016  Baicalein prevents memory deficits in AD model. … Our results strengthen the potential of the flavonoid baicaleinas a novel and promising oral …

Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid(AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.[1][2][3]

Leukotrienes use lipid signaling to convey information to either the cell producing them (autocrine signaling) or neighboring cells (paracrine signaling) in order to regulate immune responses. The production of leukotrienes is usually accompanied by the production of histamine and prostaglandins, which also act as inflammatory mediators.[citation needed]

One of their roles (specifically, leukotriene D4) is to trigger contractions in the smooth muscles lining the bronchioles; their overproduction is a major cause of inflammation in asthma and allergic rhinitis.[4] Leukotriene antagonists are used to treat these disorders by inhibiting the production or activity of leukotrienes.

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