Arvinas is developing a new class of drugs that engage the body’s own natural protein disposal system to treat cancers and other difficult-to-treat diseases.

As a potential improvement over traditional small molecule inhibitors, PROTACs (Proteolysis-Targeting Chimeras) are able to degrade disease-causing proteins through the cell’s Ubiquitin/Proteasome System, which routinely removes damaged proteins.

PROTACTM degraders work by recruiting an E3 ligase to tag the target protein for ubiquitination and degradation through the proteasome, a large complex that degrades the ubiquitinated protein into small peptides. After destruction of the protein, the PROTAC is released to continue its seek and destroy mission.

Connie’s comments:

It is similar to our body detoxing during sleep, eating whole foods, exercising and being happy surrounded by nature, good music, good people and a positive spirit.