I attended the Allergies seminar at Palo Alto Medical Foundation yesterday with Dr Steven Rubinstein.
He suggested to buy a pillow encasing and to avoid allergens. Clean your beddings using high heat regularly.
A saline nasal spray and other histamine-base meds (works on histamine only out of 70 other allergens controlled by IgE) and other med protocols are also used for short to long term.
Skin test is most appropriate compared to blood test for allergy.
Humidity is important but there is no need to buy humidifiers. Local action CPAP is appropriate.
Some meds costs $300 or more per day or month that some insurance companies are not reimbursing on these meds.
Seek all kinds of health care pros. First you see your primary docs and some millenials seek a specialist right away that is not warranted. I love naturopathic doctors.
See allergies, whole foods, sleep, immune system, dust mites, toxins, other tags and categories in this site for more info.
Email Connie at firstname.lastname@example.org for other health research you are interested in.
- Health Education Division
- Palo Alto Medical Foundation
- Mountain View: 650-934-7380
- Sunnyvale: 408-730-2810
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Histamine is involved in the inflammatory response and has a central role as a mediator of itching.
There is much speculation into what physiological benefits IgE contributes, and, so far, circumstantial evidence in animal models and statistical population trends have hinted that IgE may be beneficial in fighting gut parasites such as Schistosoma mansoni, but this has not been conclusively proven in humans. Epidemiological research shows that IgE level is increased when infected by Schistosoma mansoni, Necator americanus, and nematodes in humans. It is most likely beneficial in removal of hookworms from the lung.
Although it is not yet well understood, IgE may play an important role in the immune system’s recognition of cancer, in which the stimulation of a strong cytotoxic response against cells displaying only small amounts of early cancer markers would be beneficial. If this were the case, anti-IgE treatments such as omalizumab (for allergies) might have some undesirable side effects. However, a recent study, which was performed based on pooled analysis using comprehensive data from 67 phase I to IV clinical trials of omalizumab in various indications, concluded that a causal relationship between omalizumab therapy and malignancy is unlikely.
Role in disease
Atopic individuals can have up to ten times the normal level of IgE in their blood (as do sufferers of hyper-IgE syndrome). However, this may not be a requirement for symptoms to occur as has been seen in asthmatics with normal IgE levels in their blood—recent research has shown that IgE production can occur locally in the nasal mucosa.
IgE that can specifically recognise an allergen (typically this is a protein, such as dust mite Der p 1, cat Fel d 1, grass or ragweedpollen, etc.) has a unique long-lived interaction with its high-affinity receptor FcεRI so that basophils and mast cells, capable of mediating inflammatory reactions, become “primed”, ready to release chemicals like histamine, leukotrienes, and certain interleukins. These chemicals cause many of the symptoms we associate with allergy, such as airway constriction in asthma, local inflammation in eczema, increased mucus secretion in allergic rhinitis, and increased vascular permeability, it is presumed, to allow other immune cells to gain access to tissues, but which can lead to a potentially fatal drop in blood pressure as in anaphylaxis.
IgE is known to be elevated in various autoimmune disorders such as Lupus(SLE), Rheumatoid Arthritis(RA) & psoriasis, and is theorized to be of pathogenetic importance in RA and SLE by eliciting a hypersensitivity reaction.
Regulation of IgE levels through control of B cell differentiation to antibody-secreting plasma cells is thought to involve the “low-affinity” receptor FcεRII, or CD23. CD23 may also allow facilitated antigen presentation, an IgE-dependent mechanism whereby B cells expressing CD23 are able to present allergen to (and stimulate) specific T helper cells, causing the perpetuation of a Th2 response, one of the hallmarks of which is the production of more antibodies.
Lectins from Ricinus communis and Glycine max, as well as wheat germ agglutinin and concanavalin A, caused a dose-dependent release of histamine from mast cells present in the mixed peritoneal cells from the rat. In addition, histamine release in an IgE-mediated and a compound 48/80-mediatedreaction was inhibited …
May 9, 2015 – The EAACI recommends that the positive control, i.e. the histamine prick, could be used only to prove that the skin can react . This means that the … Hanneuse Y, Delespesse G, Hudson D, de Halleux F, Jacques JM: Influence of ageing on IgE-mediated reactions in allergic patients. Clin Allergy1978 …
The likelihood of an IgE-mediated clinical reaction often increases with the level of specific IgE, but these levels do not predict severity or guarantee a reaction will … allergen skin testing, venipuncture, and body measurements: data from the second National Health and Nutrition Examination Survey 1976–80(NHANES II).
Although everyone makes IgE, people whom are prone to allergic reactions make much larger quantities. Inheritance … If you have 1 parent that is allergic, you have a 50% chance, and if you have 2 parents with allergies, you have a 75-80% chance of being allergic. … The best known chemical that is released is histamine.
May 15, 2006 – Histamine modulates mast cell degranulation through an indirect mechanism in a modelIgE-mediated reaction …. Therefore, the mast cell population was immunomagnetically purified from the peritoneal washing and stimulated with histamine, serotonin or compound 48/80, and the degree of degranulation …
Apr 24, 2017 – We sought to determine whether SLC10A4 might play a role in mast cell-mediatedreactions independent of the IgE/antigen activation pathway in vivo. For this purpose, wild type and Slc10a4−/− mice, were given the mast cell degranulation compound 48/80 intradermally in the neck, as well as histamine or …
Feb 9, 2015 – It divides the hypersensitivity reactions into the following 4 types: Type I reactions (ie, immediate hypersensitivity reactions) involve immunoglobulin E (IgE)–mediated release of histamineand other mediators from mast cells and basophils. Examples include anaphylaxis and allergic rhinoconjunctivitis.
People with DAO insufficiency and/or histamine intolerance do not show IgE levels to foods. In other words, their skin prick tests are negative, but they still have allergic-type reactions to foods. Symptoms can include diarrhea, headache, itchy eyes and nose, asthma, wheezing after eating, low blood pressure, dizziness after …
Jan 15, 1999 – When a food protein is ingested, the IgE recognizes it on the surface of these cells; mediators (e.g., histamine) are released, and symptoms occur. …. appears to be less than 1 percent, although 25 to 80 percent of patients with documented IgE-mediated food allergy have nasal symptoms during oral food …
But now we know it’s not that simple as IgE allergy-mediated response tests usually turn up undesirable results. … At least 1 percent of the world’s population suffers from histamine intolerance, according to experts, and middle-aged women seem to be the most susceptible as they represent 80 percent of those affected. (1).