Liver cancer calculator

Activity 4B. Calculating APRI

Instructions

  1. Using the APRI Calculator tool, enter in the patient’s laboratory data and calculate the patient’s APRI score.
  2. Answer the Activity Question based on the patient’s APRI score.

AST to Platelet Ratio Index (APRI) Calculator

This is an AST to Platelet Ratio Index (APRI) calculator tool. Enter the required values to calculate the APRI value. The APRI Score will appear in the oval on the far right (highlighted in yellow). Most experts recommend using 40 IU/L as the value for the AST upper limit of normal when calculating an APRI value.

APRI =
AST Level (IU/L)
AST (Upper Limit of Normal) (IU/L)
Platelet Count (109/L)
x 100 =
3.000

Interpretation:

In a meta-analysis of 40 studies, investigators concluded that an APRI score greater than 1.0 had a sensitivity of 76% and specificity of 72% for predicting cirrhosis. In addition, they concluded that APRI score greater than 0.7 had a sensitivity of 77% and specificity of 72% for predicting significant hepatic fibrosis.1For detection of cirrhosis, using an APRI cutoff score of 2.0 was more specific (91%) but less sensitive (46%). The lower the APRI score (less than 0.5), the greater the negative predictive value (and ability to rule out cirrhosis) and the higher the value (greater than 1.5) the greater the positive predictive value (and ability to rule in cirrhosis); midrange values are less helpful. The APRI alone is likely not sufficiently sensitive to rule out significant disease. Some evidence suggests that the use of multiple indices in combination (such as APRI plus FibroTest) or an algorithmic approach may result in higher diagnostic accuracy than using APRI alone.2

Sources


Published by

connie dello buono

Health educator, author and enterpreneur motherhealth@gmail.com or conniedbuono@gmail.com ; cell 408-854-1883 Helping families in the bay area by providing compassionate and live-in caregivers for homebound bay area seniors. Blogs at www.clubalthea.com Currently writing a self help and self cure ebook to help transform others in their journey to wellness, Healing within, transform inside and out. This is a compilation of topics Connie answered at quora.com and posts in this site.

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