Cancer recruitment, collusion and collaboration with normal cells

Nov 17, 2006 – Metastasis occurs when genetically unstable cancer cells adapt to a tissue … to cancer cells and the concomitant recruitment of traits in the tumor stroma … The utter inefficiency of the metastatic process implies that healthy tissues ….. requires collusion between tumor cells and multiple nontransformed cell …

Interaction between cancer cells and normal cells of the primary organ … themselves, but rather conscript and corrupt resident and recruited normal cell types 9.

Mar 14, 2014 – Unlike tumor cells, stromal cell types within the tumor … Bidirectional communication between cells and their microenvironment is critical for both normal tissue …. M2-to-M1 switch, recruitment of natural killer (NK) cells and subsequent tumor ….. Indeed, interruption of this interaction renders metastatic cells …

Mar 7, 2016 – Through reciprocal communication, cancer cells and the microenvironment act in collusion leading to … These normal cells in the tumor microenvironment mainly consist of … The tumor cells recruit cancer-associated fibroblasts (CAFs), … the extracellular matrix (ECM) and directing cell-cell interaction (10).

Nov 15, 2015 – … are able to kill susceptible tumor cells through their interaction with their respective death receptors. …. Consequently, the oligomerized death receptors recruit the adaptor … in a wide variety of cancer cells while sparing normal cells. …… Essential complicity of perforin-granzyme and FAS-L mechanisms to …

Jul 14, 2017 – Complicity of Tumor-Associated Macrophages (TAMs) in Tumor Progression. More than 50% of tumor-infiltrating cells are macrophages, named TAMs (7, 8). … In healthy tissues, macrophages offer a remarkable plasticity to …. (B) Inhibition of circulating monocyte recruitment into the tumor: two main ..