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anti-aging

 How Pancreatic Cancer Cells, Master Scavengers, Thrive Even When Starved

Date: June 27, 2019Author: connie dello buono 0 Comments
 By Alec Kimmelman, MD, PhD

In recent years, researchers have hoped to combat pancreatic cancer by developing drugs that interfere with tumor cells’ source of fuel. But a study led by researchers at NYU Langone and other institutions has found that when their glucose fuel supply runs low, pancreatic cancer cells signal to nearby support cells for help supplying them with nourishment. The study, published in the journal Nature, was based on research conducted in collaboration with teams from the Dana-Farber Cancer Institute at Harvard University and the University of Michigan Medical School.

Intrigued by the fact that pancreatic cancer cells keep growing even when they have very little oxygen and blood sugar, or glucose, normally supplied by the bloodstream, Alec Kimmelman, MD, PhD, wanted to find out how that happened.

Intrigued by the fact that pancreatic cancer cells keep growing even when they have very little oxygen and blood sugar, or glucose, normally supplied by the bloodstream, Alec Kimmelman, MD, PhD, wanted to find out how that happened. Dr. Kimmelman, chair of the Department of Radiation Oncology, led a team of investigators that discovered that pancreatic tumor cells communicate with nearby stellate cells—healthy cells that secrete substances providing structural support. By emitting an unknown chemical, hungry tumor cells signal the stellate cells to break down their own components into various building blocks, including the amino acid alanine. In the presence of alanine, the tumor cells’ mitochondria, or cellular motors, revved up by 20 to 40 percent, indicating that the alanine was being used as fuel source in place of glucose.

When their glucose supply is limited, cancer cells can scrounge for enough nourishment to take steps that enable them to multiply, like building new strands of DNA and RNA. “In nutrient-poor conditions, alanine is providing meta­-bolic efficiency,” explains 
Dr. Kimmelman. “These tumor 
cells have an unbelievable 
capacity to scavenge and adapt.” 
When they tested this theory in mice, deactivating a gene that allows the breakdown in stellate cells, tumor growth slowed significantly compared to those grown with normal stellate cells, since they no longer had access to the 
secreted alanine.

Pancreatic cancer is one of the most lethal forms of cancer, with an overall five-year survival rate of just 7 percent. While current therapies have shown some efficacy, there is a lot of room for improvement. Dr. Kimmelman and his colleagues think it may be possible to strike back at tumor cells by limiting their scavenging abilities. “We are continuing to explore how pancreatic cancers alter their metabolism to provide essential building blocks they need,” he says. His team hopes that decoding tumor cells’ survival strategies will pave the way for future drugs that starve out pancreatic tumors.

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Published by connie dello buono

Health educator, author and enterpreneur motherhealth@gmail.com or conniedbuono@gmail.com ; cell 408-854-1883 Helping families in the bay area by providing compassionate and live-in caregivers for homebound bay area seniors. Blogs at www.clubalthea.com Currently writing a self help and self cure ebook to help transform others in their journey to wellness, Healing within, transform inside and out. This is a compilation of topics Connie answered at quora.com and posts in this site. View all posts by connie dello buono

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