Parkinsons, medications, dopamine rich foods and gut microbes

  • Dairy foods such as milk, cheese and yogurt
  • Unprocessed meats such as beef, chicken and turkey
  • Omega-3 rich fish such as salmon and mackerel
  • Eggs
  • Fruit and vegetables, in particular bananas
  • Nuts such as almonds and walnuts
  • Dark chocolate

Concentrating on levodopa (L-dopa), the essential treatment for Parkinson’s disease, they distinguished which bacteria out of the trillions of species is in charge of degrading the medication and how to stop this microbial interference. 

Parkinson’s disease attacks nerve cells in the brain that produce dopamine, without which the body can endure tremors, muscle rigidity, and issues with balance and coordination. L-dopa conveys dopamine to the brain to relieve symptoms. Yet, just around 1 to 5% of the medication really reaches the brain. 

Researchers realized that the body’s enzymes (instruments that perform essential science) can separate L-dopa in the gut, keeping the medication from arriving at the brain. 

A decent number tie to tyrosine–an amino acid like L-dopa. What’s more, one, from a food microbe frequently found in milk and pickles (Lactobacillus brevis), can acknowledge both tyrosine and L-dopa. 

Despite the fact that the human and bacterial enzymes play out precisely the same chemical reactions, the bacterial one looks only somewhat changed. 

Hypothesized that carbidopa will most likely be unable to infiltrate the microbial cells or the slight structural difference could keep the medication from cooperating with the bacterial protein. Assuming genuine, other host-focused on medicines might be similarly as incapable as carbidopa against similar microbial machinations. 

Pushed further to unravel a second step in the microbial metabolism of L-dopa. After E. faecalis changes over the medication into dopamine, a second organism being changes over dopamine into another compound, meta-tyramine. Feeding dopamine to swarms of microbes to see which succeeded.

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