In each study, the people with hearing loss had higher rates of dementia. In one study, people with hearing loss were 24% more likely to have Alzheimer’s. In another, they found that the worse the hearing loss was, the more likely the person was to develop dementia.
- This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for TOM1 Gene
TOM1 (Target Of Myb1 Membrane Trafficking Protein) is a Protein Coding gene. Diseases associated with TOM1 include Deafness, Autosomal Recessive 37 and Deafness, Autosomal Dominant 22. Among its related pathways are C-MYB transcription factor network and Innate Immune System. Gene Ontology (GO) annotations related to this gene include clathrin binding. An important paralog of this gene is TOM1L2.
UniProtKB/Swiss-Prot for TOM1 Gene
Reducing the expression of the protein TOM1 in mouse models of Alzheimer’s disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects.