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What is considered the most fundamental root cause of sickness and disease?

My answer to What is considered the most fundamental root cause of sickness and disease?

Answer by Connie b. Dellobuono:

  1. infection and inflammation (virus,fungus,stress,others, concussions,trauma,bacterial,parasitic,microbial,)
  2. toxins from environment (radiation, pollution, second had smoke,) and food/alcohol/smoking which creates damaging gut microbes and harms our organs (pancreas harmed by sugar)
  3. nervous system disorder: depression, panic, neurological which affects (decreases) our immune system
  4. unknowns (genetics ~20%) and lifestyle (sleep late and less than 6hrs per day,night work, no exercise, no Vitamin D3 (sun exposure)

What is considered the most fundamental root cause of sickness and disease?

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