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Exercise induces changes in skeletal muscle to purge the blood from toxins

In a new study in mice, researchers at Karolinska Institutet show that exercise training induces changes in skeletal muscle that can purge the blood of a substance that accumulates during stress and is harmful to the brain. The study is being published in the journal Cell.

“In neurobiological terms, we actually still don’t know what depression is. Our study represents another piece in the puzzle, since we provide an explanation for the protective biochemical changes induced by physical exercise that prevent the brain from being damaged during stress,” says Mia Lindskog, researcher at the Department of Neuroscience at Karolinska Institutet.

It was known that the protein PGC-1a1 (pronounced PGC-1alpha1) increases in skeletal muscle with exercise, and mediates the beneficial muscle conditioning in connection with physical activity. In this study researchers used a genetically modified mouse with high levels of PGC-1a1 in skeletal muscle that shows many characteristics of well-trained muscles (even without exercising).

These mice, and normal control mice, were exposed to a stressful environment, such as loud noises, flashing lights and reversed circadian rhythm at irregular intervals. After five weeks of mild stress, normal mice had developed depressive behaviour, whereas the genetically modified mice (with well-trained muscle characteristics) had no depressive symptoms.

“Our initial research hypothesis was that trained muscle would produce a substance with beneficial effects on the brain. We actually found the opposite: well-trained muscle produces an enzyme that purges the body of harmful substances. So in this context the muscle’s function is reminiscent of that of the kidney or the liver,” says Jorge Ruas, principal investigator at the Department of Physiology and Pharmacology, Karolinska Institutet.

Convert a substance formed during stress

The researchers discovered that mice with higher levels of PGC-1a1 in muscle also had higher levels of enzymes called KAT. KATs convert a substance formed during stress (kynurenine) into kynurenic acid, a substance that is not able to pass from the blood to the brain. The exact function of kynurenine is not known, but high levels of kynurenine can be measured in patients with mental illness.

In the current study, the researchers demonstrated that when normal mice were given kynurenine, they displayed depressive behaviour, while mice with increased levels of PGC-1a1 in muscle were not affected. In fact, these animals never show elevated kynurenine levels in their blood since the KAT enzymes in their well-trained muscles quickly convert it to kynurenic acid, resulting in a protective mechanism.

“It’s possible that this work opens up a new pharmacological principle in the treatment of depression, where attempts could be made to influence skeletal muscle function instead of targeting the brain directly. Skeletal muscle appears to have a detoxification effect that, when activated, can protect the brain from insults and related mental illness,” says Jorge Ruas.

350 million people affected

Depression is a common psychiatric disorder worldwide. The World Health Organization (WHO) estimates that more than 350 million people are affected.

The current study was funded by grants from the AstraZeneca-Karolinska Institutet Integrated Translational Research Centre, the Novo Nordisk Foundation, the Petrus and Augusta Hedlund Foundation, Stockholm County Council, Karolinska Institutet’s Strategic Research Programme in Diabetes, the Swedish Brain Foundation, the Swedish Diabetes Association, the Swedish Foundation for Strategic Research, the Swedish Research Council, the Knut and Alice Wallenberg Foundation, the Åhlén Foundation and the Åke Wiberg Foundation, among others.

https://news.ki.se/how-physical-exercise-protects-the-brain-from-stress-induced-depression

Menopausal hormone therapy use and risk of primary liver cancer

Primary liver cancer occurs less commonly among women than men in almost all countries.

This discrepancy has suggested that hormone levels and/or exogenous hormone use could have an effect on risk, although prior studies have reached inconsistent conclusions. Thus, the current study was conducted to examine the relationship between menopausal hormone therapy (MHT) use and development of liver cancer. A nested case-control study was conducted within the United Kingdom’s Clinical Practice Research Datalink (CPRD). Controls were matched, at a 4-to-1 ratio, to women diagnosed with primary liver cancer between 1988 and 2011. A second match, based on whether the cases and controls had diabetes, was also conducted. Odds ratios (OR) and 95% confidence intervals (95%CI) for associations of MHT with liver cancer were estimated using conditional logistic regression adjusted for known risk factors.

In the overall match, 339 women with liver cancer were matched to 1318 controls. MHT use was associated with a significantly lower risk of liver cancer (ORadj=0.58, 95%CI=0.37–0.90) especially among users of estrogen-only MHT (ORadj=0.44, 95%CI=0.22–0.88) and among past users (ORadj=0.53, 95%CI=0.32–0.88). Among the matched cases (n=58) and controls (n=232) with diabetes, the odds ratios were similar to the overall analysis (ORadj=0.57, 95%CI=0.09–3.53), but did not attain statistical significance. In the current study, MHT use, especially estrogen-only MHT use, was associated with a significantly lower risk of liver cancer. These results support the need of further investigation into whether hormonal etiologies can explain the variation in liver cancer incidence between men and women.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764427/

Alcohol: women vs men

Alcohol: WOMEN VS. MEN
How often women tend to drink and what happens to their bodies when they do is
different when compared to men.

  • Self-report surveys of men and women in the United States show that alcohol
    use is more prevalent among men than women.
  • Men are more likely than women to become alcohol dependent.
  • Binge drinking (i.e., consumption of five or more drinks per occasion on 5 or
    more days in the past month) is most common among women ages 18 to 25.
  • Among racial groups, women’s drinking is more prevalent among whites,
    although black women are more likely to drink heavily.
  • Women absorb and metabolize alcohol differently than men.
  • Women generally have less body water than men of similar body weight, so that
    women achieve higher concentrations of alcohol in the blood after drinking equivalent amounts of alcohol.
  • Women DO appear to eliminate alcohol from the blood faster than men.
  • This finding may be explained by women’s higher liver volume per unit lean
    body mass, because alcohol is metabolized almost entirely in the liver.

  • Ability to Dilute Alcohol

  • WOMEN: Average Total Body Water: 52%
    MEN: Average Total Body Water: 61%

  • Ability to Metabolize Alcohol

  • WOMEN: Have a smaller quantity of dehydrogenase, an enzyme that breaks down
    alcohol.
    MEN: Have a larger quantity of dehydrogenase, which allows them to break down
    the alcohol they take in more quickly.

  • Hormonal Factors, Part 1

  • WOMEN: Premenstrual hormonal changes cause intoxication to set in faster during
    the days right before a woman gets her period.
    MEN: Their susceptibility to getting drunk does not fluctuate dramatically at certain
    times of the month.

  • Hormonal Factors, Part 2

  • WOMEN: Alcohol increases estrogen levels. Birth control pills or other medicine with estrogen increase intoxication.
    MEN: Alcohol also increases estrogen levels in men. Chronic alcoholism has been
    associated with loss of body hair and muscle mass, development of swollen breasts
    and shrunken testicles, and impotence.
    Source: NIAAA
    Source: http://www.factsontap.org

Alcohol Metabolism, in men vs women

Alcohol Metabolism: An Update from the National Institute of Alcohol Abuse and Alcoholism

We would like to apologize for an outdated and insensitive article on women and alcohol that was here.  The content of the article did not reflect the values of our office.  We are sorry for the harm that the article may have caused people who read it.

Alcohol Metabolism: An Update from the National Institute of Alcohol Abuse and Alcoholism

Drinking heavily puts people at risk for many adverse health consequences, including alcoholism, liver damage, and various cancers. But some people appear to be at greater risk than others for developing these problems. Why do some people drink more than others? And why do some people who drink develop problems, whereas others do not?

Research shows that alcohol use and alcohol-related problems are influenced by individual variations in alcohol metabolism, or the way in which alcohol is broken down and eliminated by the body. Alcohol metabolism is controlled by genetic factors, such as variations in the enzymes that break down alcohol; and environmental factors, such as the amount of alcohol an individual consumes and his or her overall nutrition. Differences in alcohol metabolism may put some people at greater risk for alcohol problems, whereas others may be at least somewhat protected from alcohol’s harmful effects.

This Alcohol Alert from the National Institute of Alcohol Abuse and Alcoholism describes the basic process involved in the breakdown of alcohol, including how toxic byproducts of alcohol metabolism may lead to problems such as alcoholic liver disease, cancer, and pancreatitis. This Alert also describes populations who may be at particular risk for problems resulting from alcohol metabolism as well as people who may be genetically “protected” from these adverse effects.

THE CHEMICAL BREAKDOWN OF ALCOHOL

Alcohol is metabolized by several processes or pathways. The most common of these pathways involves two enzymes—alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). These enzymes help break apart the alcohol molecule, making it possible to eliminate it from the body. First, ADH metabolizes alcohol to acetaldehyde, a highly toxic substance and known carcinogen (1). Then, in a second step, acetaldehyde is further metabolized down to another, less active byproduct called acetate (1), which then is broken down into water and carbon dioxide for easy elimination (2).

Other enzymes—

The enzymes cytochrome P450 2E1 (CYP2E1) and catalase also break down alcohol to acetaldehyde. However, CYP2E1 only is active after a person has consumed large amounts of alcohol, and catalase metabolizes only a small fraction of alcohol in the body (1). Small amounts of alcohol also are removed by interacting with fatty acids to form compounds called fatty acid ethyl esters (FAEEs). These compounds have been shown to contribute to damage to the liver and pancreas (3).

The Chemical Breakdown of Alcohol
The chemical name for alcohol is ethanol (CH3CH2OH). The body processes and eliminates ethanol in separate steps. Chemicals called enzymes help to break apart the ethanol molecule into other compounds (or metabolites), which can be processed more easily by the body. Some of these intermediate metabolites can have harmful effects on the body.

Most of the ethanol in the body is broken down in the liver by an enzyme called alcohol dehydrogenase (ADH), which transforms ethanol into a toxic compound called acetaldehyde (CH3CHO), a known carcinogen. However, acetaldehyde is generally short-lived; it is quickly broken down to a less toxic compound called acetate (CH3COO–) by another enzyme called aldehyde dehydrogenase (ALDH). Acetate then is broken down to carbon dioxide and water, mainly in tissues other than the liver.

Acetaldehyde: a toxic byproduct—Much of the research on alcohol metabolism has focused on an intermediate byproduct that occurs early in the breakdown process—acetaldehyde. Although acetaldehyde is short lived, usually existing in the body only for a brief time before it is further broken down into acetate, it has the potential to cause significant damage. This is particularly evident in the liver, where the bulk of alcohol metabolism takes place (4). Some alcohol metabolism also occurs in other tissues, including the pancreas (3) and the brain, causing damage to cells and tissues (1). Additionally, small amounts of alcohol are metabolized to acetaldehyde in the gastrointestinal tract, exposing these tissues to acetaldehyde’s damaging effects (5).

In addition to its toxic effects, some researchers believe that acetaldehyde may be responsible for some of the behavioral and physiological effects previously attributed to alcohol (6). For example, when acetaldehyde is administered to lab animals, it leads to incoordination, memory impairment, and sleepiness, effects often associated with alcohol (7).

On the other hand, other researchers report that acetaldehyde concentrations in the brain are not high enough to produce these effects (7). This is because the brain has a unique barrier of cells (the blood–brain barrier) that help to protect it from toxic products circulating in the bloodstream. It’s possible, however, that acetaldehyde may be produced in the brain itself when alcohol is metabolized by the enzymes catalase (8,9) and CYP2E1 (10).

THE GENETICS BEHIND METABOLISM

Regardless of how much a person consumes, the body can only metabolize a certain amount of alcohol every hour (2). That amount varies widely among individuals and depends on a range of factors, including liver size (1) and body mass.

In addition, research shows that different people carry different variations of the ADH and ALDH enzymes. These different versions can be traced to variations in the same gene. Some of these enzyme variants work more or less efficiently than others; this means that some people can break down alcohol to acetaldehyde, or acetaldehyde to acetate, more quickly than others. A fast ADH enzyme or a slow ALDH enzyme can cause toxic acetaldehyde to build up in the body, creating dangerous and unpleasant effects that also may affect an individual’s risk for various alcohol-related problems—such as developing alcoholism.

The type of ADH and ALDH an individual carries has been shown to influence how much he or she drinks, which in turn influences his or her risk for developing alcoholism (11). For example, high levels of acetaldehyde make drinking unpleasant, resulting in facial flushing, nausea, and a rapid heart beat. This “flushing” response can occur even when only moderate amounts of alcohol are consumed. Consequently, people who carry gene varieties for fast ADH or slow ALDH, which delay the processing of acetaldehyde in the body, may tend to drink less and are thus somewhat “protected” from alcoholism (although, as discussed later, they may be at greater risk for other health consequences when they do drink).

Genetic differences in these enzymes may help to explain why some ethnic groups have higher or lower rates of alcohol-related problems. For example, one version of the ADH enzyme, called ADH1B*2, is common in people of Chinese, Japanese, and Korean descent but rare in people of European and African descent (12). Another version of the ADH enzyme, called ADH1B*3, occurs in 15 to 25 percent of African Americans (13). These enzymes protect against alcoholism (14) by metabolizing alcohol to acetaldehyde very efficiently, leading to elevated acetaldehyde levels that make drinking unpleasant (15). On the other hand, a recent study by Spence and colleagues (16) found that two variations of the ALDH enzyme, ALDH1A1*2 and ALDH1A1*3, may be associated with alcoholism in African-American people.

Although these genetic factors influence drinking patterns, environmental factors also are important in the development of alcoholism and other alcohol-related health consequences. For example, Higuchi and colleagues (17) found that as alcohol consumption in Japan increased between 1979 and 1992, the percentage of Japanese alcoholics who carried the protective ADH1B*2 gene version increased from 2.5 to 13 percent. Additionally, despite the fact that more Native American people die of alcohol-related causes than do any other ethnic group in the United States, research shows that there is no difference in the rates of alcohol metabolism and enzyme patterns between Native Americans and Whites (18). This suggests that rates of alcoholism and alcohol-related problems are influenced by other environmental and/or genetic factors.

HEALTH CONSEQUENCES OF ALCOHOL USE

Alcohol metabolism and cancer—Alcohol consumption can contribute to the risk for developing different cancers, including cancers of the upper respiratory tract, liver, colon or rectum, and breast (19). This occurs in several ways, including through the toxic effects of acetaldehyde (20).

Where Alcohol Metabolism Takes Place
Alcohol is metabolized in the body mainly by the liver. The brain, pancreas, and stomach also metabolize alcohol.

Many heavy drinkers do not develop cancer, and some people who drink only moderately do develop alcohol-related cancers. Research suggests that just as some genes may protect individuals against alcoholism, genetics also may determine how vulnerable an individual is to alcohol’s carcinogenic effects (5).

Ironically, the very genes that protect some people from alcoholism may magnify their vulnerability to alcohol-related cancers. The International Agency for Research on Cancer (21) asserts that acetaldehyde should be classified as a carcinogen. Acetaldehyde promotes cancer in several ways—for example, by interfering with the copying (i.e., replication) of DNA and by inhibiting a process by which the body repairs damaged DNA (5). Studies have shown that people who are exposed to large amounts of acetaldehyde are at greater risk for developing certain cancers, such as cancers of the mouth and throat (5). Although these individuals often are less likely to consume large amounts of alcohol, Seitz and colleagues (5) suggest that when they do drink their risk for developing certain cancers is higher than drinkers who are exposed to less acetaldehyde during alcohol metabolism.

Acetaldehyde is not the only carcinogenic byproduct of alcohol metabolism. When alcohol is metabolized by CYP2E1, highly reactive, oxygen-containing molecules—or reactive oxygen species (ROS)—are produced. ROS can damage proteins and DNA or interact with other substances to create carcinogenic compounds (22).

Fetal Alcohol Spectrum Disorder (FASD)—Pregnant women who drink heavily are at even greater risk for problems. Poor nutrition may cause the mother to metabolize alcohol more slowly, exposing the fetus to high levels of alcohol for longer periods of time (23). Increased exposure to alcohol also can prevent the fetus from receiving necessary nutrition through the placenta (24). In rats, maternal malnutrition has been shown to contribute to slow fetal growth, one of the features of FASD, a spectrum of birth defects associated with drinking during pregnancy (23). These findings suggest that managing nutrition in pregnant women who drink may help to reduce the severity of FASD (25).

Alcoholic liver disease—As the chief organ responsible for the breakdown of alcohol, the liver is particularly vulnerable to alcohol metabolism’s effects. More than 90 percent of people who drink heavily develop fatty liver, a type of liver disease. Yet only 20 percent will go on to develop the more severe alcoholic liver disease and liver cirrhosis (26).

Alcoholic pancreatitis—Alcohol metabolism also occurs in the pancreas, exposing this organ to high levels of toxic byproducts such as acetaldehyde and FAEEs (3). Still, less than 10 percent of heavy alcohol users develop alcoholic pancreatitis—a disease that irreversibly destroys the pancreas— suggesting that alcohol consumption alone is not enough to cause the disease. Researchers speculate that environmental factors such as smoking and the amount and pattern of drinking and dietary habits, as well as genetic differences in the way alcohol is metabolized, also contribute to the development of alcoholic pancreatitis, although none of these factors has been definitively linked to the disease (27).

CONCLUSION

Researchers continue to investigate the reasons why some people drink more than others and why some develop serious health problems because of their drinking. Variations in the way the body breaks down and eliminates alcohol may hold the key to explaining these differences. New information will aid researchers in developing metabolism-based treatments and give treatment professionals better tools for determining who is at risk for developing alcohol-related problems.

REFERENCES

(1) Edenberg, H.J. The genetics of alcohol metabolism: Role of alcohol dehydrogenase and aldehyde dehydrogenase variants. Alcohol Research & Health 30(1):5–13, 2007. (2) National Institute on Alcohol Abuse and Alcoholism. Alcohol Alert: Alcohol Metabolism. No. 35, PH 371. Bethesda, MD: the Institute, 1997 (3) Vonlaufen, A.; Wilson, J.S.; Pirola, R.C.; and Apte, M.V. Role of alcohol metabolism in chronic pancreatitis. Alcohol Research & Health 30(1):48–54, 2007. (4) Zakhari, S. Overview: How is alcohol metabolized by the body? Alcohol Research & Health 29(4):245–254, 2006. (5) Seitz, H.K., and Becker, P. Alcohol metabolism and cancer risk. Alcohol Research & Health 30(1):38–47, 2007. (6) Deitrich, R., Zimatkin, S., and Pronko S. Oxidation of ethanol in the brain and its consequences. Alcohol Research & Health 29(4):266–273, 2006. (7) Quertemont, E., and Didone, V. Role of acetaldehyde in mediating the pharmacological and behavioral effects of alcohol. Alcohol Research & Health 29(4):258–265, 2006. (8) Aragon, C.M.; Rogan, F.; and Amit, Z. Ethanol metabolism in rat brain homogenates by a catalase–H2O2 system. Biochemical Pharmacology 44:93–98, 1992. (9) Gill, K.; Menez, J.F.; Lucas, D.; and Deitrich, R.A. Enzymatic production of acetaldehyde from ethanol in rat brain tissue. Alcoholism: Clinical and Experimental Research 16:910–915, 1992. (10) Warner, M., and Gustafsson, J.A. Effect of ethanol on cytochrome P450 in the rat brain. Proceedings of the National Academy of Sciences of the United States of America 91:1019–1023, 1994. (11) Hurley, T.D.; Edenberg, H.J.; Li, T.-K. The Pharmacogenomics of alcoholism. In: Pharmacogenomics: The Search for Individualized Therapies. Weinheim, Germany: Wiley–VCH, 2002, pp. 417–441. (12) Oota, H.; Pakstis, A.J.; and Bonne-Tamir, B. The evolution and population genetics of the ALDH2 locus: Random genetic drift, selection, and low levels of recombination. Annals of Human Genetics 68(Pt. 2):93–109, 2004. (13) Bosron, W.F., and Li, T.-K. Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme 37:19–28, 1987. (14) Ehlers, C.L.; Gilder, D.A.; Harris L.; and Carr L. Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. Alcoholism: Clinical and Experimental Research 25:1773–1777, 2001. (15) Crabb, D.W. Ethanol oxidizing enzymes: Roles in alcohol metabolism and alcoholic liver disease. Progress in Liver Disease 13:151–172, 1995. (16) Spence, J.P.; Liang, T.; Eriksson, C.J.; et al. Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. Alcoholism: Clinical and Experimental Research 27:1389–1394, 2003. . (17) Higuchi, S.; Matsushita, S.; Imazeki, H.; et al. Aldehyde dehydrogenase genotypes in Japanese alcoholics. Lancet 343:741–742, 1994 (18) Bennion, L.J., and Li, T.-K. Alcohol metabolism in American Indians and whites: Lack of racial differences in metabolic rate and liver alcohol dehydrogenase. New England Journal of Medicine 294:9–13, 1976. (19) Bagnardi, V.; Blangiardo, M.; La Vecchia, C.; and Corrao, G. Alcohol consumption and the risk of cancer: A meta-analysis. Alcohol Research & Health 25(4):263–270, 2001. (20) Koop, D.R. Alcohol metabolism’s damaging effects on the cell: A focus on reactive oxygen generation by the enzyme cytochrome P450 2E1. Alcohol Research & Health 29(4):274–280, 2006. (21) International Agency for Research on Cancer (IARC). Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. In: Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Acetaldehyde No. 77. Lyon, France: IARC, 1999, pp. 319–335. (22) Seitz, H.K., and Stickel, F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biological Chemistry 387:349–360, 2006. (23) Shankar, K.; Hidestrand, M.; Liu, X.; et al. Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity. Experimental Biology and Medicine 231:1379–1397, 2006. (24) Dreosti, I.E. Nutritional factors underlying the expression of the fetal alcohol syndrome. Annals of the New York Academy of Sciences 678:193–204, 1993.  (25) Shankar, K.; Ronis, M.J.J.; Badger, T.M. Effects of pregnancy and nutritional status on alcohol metabolism. Alcohol Research & Health 30(1):55–59, 2007. (26) McCullough, A.J., and O’Connor, J.F. Alcoholic liver disease: Proposed recommendations for the American College of Gastroenterology. American Journal of Gastroenterology 93(11): 2022–2036, 1998. (27) Ammann, R.W. The natural history of alcoholic chronic pancreatitis. Internal Medicine 40(5):368–375, 2001.

Adapted from the NIAAA Alcohol Alert: http://pubs.niaaa.nih.gov/publications/AA72/AA72.pdf

Health – Washington Post

After Trump blames mental illness for mass shootings, health agencies ordered to hold all posts on issue

‘There is this climate of concern whether you can make a statement based on facts,’ said an employee at the National Institutes of Health.

  • Perspective

Children, tackle football and the possible dangers of brain diseases

Kids playing the sport can face the threat of concussions, cognitive troubles and behavioral problems.

  • Robert C. Cantu and Mark Hyman

More parents give dietary supplements to kids. But experts warn about their potential danger.

Physicians, others argue that just because such products are on store shelves doesn’t mean they’re safe for your children.

  • Erin Blakemore

More troubling signs that ultra-processed foods can hurt your health

Early deaths, cardiovascular disease may be linked to high consumption of such food, studies say.

He’s 26 years old but still sees a pediatrician: Why some young adults don’t move on

The doctors are seeing more 20-something patients because of convenience, health needs and parental insurance coverage to age 26. And that’s ok — mostly.

  • Caren Chesler

Families of gay kids were once seen as the enemy by support groups. That’s changing.

Today, there is a growing recognition that help from parents and other relatives is critical to the well-being of LGBT youth.

  • Marlene Cimons

‘I began feeling like I mattered’: How on-campus mental health counseling can make a big difference

Austin school district’s clinics quickly help youths struggling with depression, anxiety, other trauma-related issues.

  • David Leffler

The Big Number: How 48 minutes of extra sleep helped these teens

Later school start times found high schoolers and middle-schoolers less sleepy and generally more engaged in academics.

  • Linda Searing
  • Perspective

This allergist thinks some dirt and grime can be good for your kids

Experts think that we might be oversanitizing the environment for children, which could be leading to common health problems.

  • Cosby Stone

Naloxone, a drug that reverses overdoses, can save lives. Here’s why you should learn how to use it.

It’s a skill you may need, especially if you know someone who takes large doses of prescription opioids or abuses such drugs.

  • Erin Blakemore

Mystery lung illness linked to vaping. Health officials investigating nearly 100 possible cases.

State and federal health officials are investigating dozens of cases of mystery lung illnesses related to vaping in young people across the country. The states include California, Illinois, Indiana, Minnesota and Wisconsin.

FDA’s proposed new cigarette warnings are scary. That’s the point.

U.S. Food and Drug Administration has proposed graphic health warnings for cigarette packages to raise further awareness about smoking risks.

Planned Parenthood to exit federal program Aug. 19 over abortion ‘gag rule’ unless court rules in its favor

The women’s health clinic has said the changes are morally wrong and could potentially endanger the lives of its patients.

New antibiotic approved for drug-resistant tuberculosis

The drug was developed by a nonprofit group, in what some hope will become an alternative model since drug companies have largely abandoned the unprofitable work.

Agency did not conduct required oversight of program for those with disabilities

Health and Human Services did not conduct a single on-site visit of independent living programs, its inspector general found.

U.S. health panel recommends doctors screen all adults for illicit drug use

If finalized, the task force’s guidelines would make screening free or low-cost.

Abortion support remains steady despite growing partisan divide, survey finds

One of the largest-ever surveys on attitudes about abortion shows an increased partisan divide. But support for abortion remains steady, with no more than a quarter of residents in any state supporting a total ban.

A flight attendant who contracted measles has died amid a global rise in outbreaks

The flight attendant, who had reportedly received one of two immunizations, had been in a coma since April.

A revenge-seeking woman went viral by telling men she gave them HIV. Then police asked for a blood test.

How does a woman who describes herself as “nasty and evil” get revenge? A viral video telling men she gave them HIV.

Newark begins giving residents bottled water amid ongoing lead problems

“Newark is what keeps me up at night now,” says the pediatrician who helped expose the Flint water crisis.

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Why is there a need for senior apartments or care homes with caregivers

The hospital or rehabs or nursing facilities are not a place to get personalize care and recover early but in assisted living and care homes or senior homes with personalize care and at what cost?  Care homes in San Jose starts at $3500 while assisted living with nursing care in Carmel and Monterey start at $11000.

Call or text Connie for caregivers at home or care homes with caregiver referral at 408-854-1883

Calling investors who wanted a senior apartments with home care in the same building. Email motherhealth@gmail.com

Free cancer-free ebook 160 pages vol. 1 click here.

card mother

Why recover at home and not in the hospital?

In familiar, loving, caring, close to nature surroundings and away from possible nasocomial infections or infectious organisms, recovering at home or in a bay area care home with a caregiver is more personalize and conducive to early recovery.

We recommend care homes and match you with caregivers if you want to stay in your bay area house and is over 60 yrs of age with or without long term care insurance, private pay. 4088541883

card mother

Free cancer-free ebook 150 pages vol. 1 click here.

Coffee and ginger hot drink

Ingredients

fresh ginger, honey or brown sugar, coffee, water

Instruction

  1. Cut fresh ginger in small pieces and let it boil for 5 minutes.
  2. Mix hot ginger and coffee in 50:50 proportion.
  3. Sweeten with honey or brown sugar or coconut sugar.
  4. Serve hot.

Story

Our senior client who is bedridden and terminally ill loves this coffee ginger mix. Ginger cleans the blood while coffee is  a stimulant. Use decaf or diluted coffee if there is heart issues. Only drink a cup in the morning with protein rich breakfast of egg (soft boiled). You can use ginger powder.

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How my grandma self hacked health and healing

At 94 yrs of age, she cannot prolong her life any longer with no nutrition and with heavy work during her lifetime as breadwinner in the family and going to each son or daughter (7 children) and taking care of her grandchildren.

But Claudia Defensor Poral showed me healing ways that science can explain now how it promoted health.

  • Massaging the inner palm of hands, armpit and inner thighs where the lymph nodes are located. This massage can heal a fever in shorter period of time and provide relief in many ways.
  • Using garlic, ginger and other herbs to include in her massage oil or soups.
  • Burning the egg yolk as skin paste to kill fungus and washing with boiled guava leaves.
  • Burn the rice as activated charcoal for diarrhea and stomach problems.
  • Making other herbal poultice for all kinds of home health remedies.
  • Her staple nourishment comes from boiled greens, sweet potatoes, green plantain bananas and boiled eggs.
  • For her leg pain, her massage oil is a combo of ginger, garlic, salt and other herbs such as yerba buena, lemon grass and oregano.
  • She would create a bonfire in the backyard and curse the evil spirits if she think they are the cause of a sudden aches and pain of one of her children or their families.
  • She prays in Latin.
  • ——–

Share your grandma’s healing tips here

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Thank you for your response. ✨

 

Free ebook “curated cancer-free ebook” and kickstarter crowdfunding coming soon

Who are you?

Connie Dello Buono, blogger and health author , http://www.clubalthea.com
Currently works at Google Ads as content writer for Cognizant

  • What are you planning to make?

    Get the free sample of the ebook cancer-free ebook 150 pages click here for vol. 1

  • Where did this project come from?

    My parents both died of cancer and I have been caring for seniors in the bay area and teaching caregivers how to prolong their lives with healthy soups and massage.

  • What’s your plan, and what’s your schedule?

    Release the ebook soon and the hardcover by next month to be free to all libraries in the world, at least 45 countries.

  • What’s your budget?

    It will cost $5 to print the book and wished to print 1000 pieces

  • Why do you care?

    I want to empower others to prevent cancer and to start early being proactive about their health and others.

New sensory organ under the skin that can detect pain

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