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New uses for CBD in genetic brain disorder

By Dr. Liji Thomas, MDSep 19 2019

Cannabidiol (CBD) has been much in the news for the right reasons, as it is being found to have a host of medical applications. Now a new study shows that this marijuana extract can help people with a rare brain condition called Angelman syndrome to improve behavioral traits and to control their seizures.

This syndrome is present at birth, caused by the absence or mutation of the UBE3A gene from the mother. It causes intellectual retardation, inability to speak, impaired gait and balance, irregular brain waves leading to frequent seizures, which not only harm brain function and the patient’s overall health further but often do not respond to anti-seizure drugs.

The study was published in the Journal of Clinical Investigation on September 10, 2019.

CBD is known to have anti-seizure effects, to reduce anxiety, and counter psychosis. It has received approval from the US Food and Drug Administration (FDA) as a drug for treating two infrequently encountered forms of epilepsy. However, this study deals with its use in Angelman syndrome, to reduce behavioral abnormalities and to control seizure activity.

Angelman syndrome was reproduced in mousemodels, and they were then treated with CBD in increasing doses, while observing seizure patterns and frequencies, motor problems and abnormalities in brain electrical activity on electroencephalography (EEG).

The researchers discovered that a single dose of CBD by injection significantly reduced the severity of seizures that had been triggered by causing a rise in body temperature or loud noises. At a dose of 100 mg/kg, which is usually used in epilepsy, CBD causes the mice to become a little sedated but without any other significant benefit on motor skills or memory. However, the mice with AS are different from AS in humans, in that the former show reduced motor activity while the latter are often hyperactive. The higher the dose, the greater was the sedation produced. The impaired brain rhythms were normalized as well.

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However, the administration of CBD could not produce any change in the neuroplastic changes which could then lead to the establishment of a seizure focus. Neuroplasticity refers to the way the central nervous system can respond to a variety of normal or disease-related stimuli by a change in its structure or function, which may be only for a short while or durably. This is achieved by producing both new neurons and their connections.

Neuroplastic changes constantly go on, at any stage of life, and may compensate for cerebral damage. In some cases, neuroplasticity can cause neurological development or degenerative illness, as in childhood seizures. This is called epileptogenesis, and is due to progressive reorganization of the neural network. CBD was unable to arrest the process of neuroplasticity which led to the emergence of epileptogenic foci, whether it was given as a single dose or over two weeks just after a kindling protocol (when repeated seizures are induced to produce longer and more severe induced seizures until they reach a steady state).

This promising study serves as a foundation to build the correct dosage and use of CBD as a rational therapy for Angelman-associated seizures and also those found in other similar conditions. However, the researchers emphasize that the drug must be tested in human clinical trials, and to be taken only under medical supervision.

Journal reference:

Bin Gu, Manhua Zhu, Madison R. Glass, Marie Rougié, Viktoriya D. Nikolova, Sheryl S. Moy, Paul R. Carney, and Benjamin D. Philpot. Cannabidiol attenuates seizures and EEG abnormalities in Angelman syndrome model mice. Journal of Clinical Investigation. https://doi.org/10.1172/JCI130419. September 10, 2019

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Our water and foods can be contaminated with arsenic and other heavy metals that can produce pain and other nerve damage.

Aside from foods rich in Vitamin C, B complex and A, a small amount of selenium can help repair the damage.

Selenium repairs chromosome damage. It is also needed for the conversion of thyroid hormone, form T4 to T3. … Selenium also prevents viral replication and helps detoxify arsenic, beryllium, cadmium, mercury and silver.

Holistic ways

• Take vitamin B complex in the morning and in mid-afternoon, vitamin C and E and selenium and magnesium
• Foot baths: half a cup of hydrogen peroxide and Epsom salts
• Ginger tea: fresh with hot water from boiled pineapple with washed skin
• Sprinkle Brewer’s yeast in soups and cereal
• Add these herbs in cooked foods: cilantro, oregano and thyme
• Add lemon in warm water for drinking/tea/soups

Exercise

https://www.prevention.com/fitness/workouts/a20475619/stretches-for-sciatic-nerve-pain/

Email eulalie@kitss.com or motherhealth@gmail.com for a 13-week nurse job in SF and Oakland. Please specify your pay range.  We are always looking for nurses and caregivers.

Be it a travel nurse, home health or bay area nurse, you are an important team in bringing quality of life to the bay area.

Nurses are dedicated members of a health care team with goals of helping patients be comfortable and have courage in the most vulnerable point in their lives.

Caregivers at home are important extension of the care team that can save at lot of money for the family.

Text 408-854-1883 if you need a live in caregiver in the bay area.

Peripheral neuropathy is damage to the peripheral nervous system. … The heavy metals that cause peripheral neuropathy are lead, arsenic, thallium, and mercury. When these elements are in organic or inorganic compounds they become toxic to humans and animals. Arsenic poisoning can mimic Gullain-Barr disease.

When presented with nerve pain and blackened feet, I suspected heavy metal  toxicity. Her liver test did not show any signs. She is vegan and doesn’t eat meat and eggs.

Suggested foods

• cilantro
• garlic
• wild blueberries
• lemon water
• spirulina
• chlorella
• barley grass juice powder
• Atlantic dulse
• oregano
• ginger
• pineapple
• Brewer’s yeast
• Vitamin B complex and C

Foot soak

• baking soda
• hydrogen peroxide
• EPSOM salts
• ginger

Massage Oil

• almond oil or coconut oil (base oil)
• eucalyptus and rosemary essential oil (5% each, 90% base oil)

Sunshine, exercise, massage and deep breathing

About Motherhealth bay area caregivers
Eggplant and apple cider vinegar for skin cancer
Home page / Archives
Philippines Coconut Wine -Tuba
Signs of the preactive and active phase of dying, medications for terminally ill
Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
How important is the thymus gland in keeping your body free from diseases?
Skin keeps time independent of the brain
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Increased inflammatory activity in patients with FTD dementia
MEDICATIONS TO AVOID that worse PD (Parkinson’s disease)
Your complete DNA sequence will help shape the future of medicine
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Depression Affects Male and Female Brains Differently
Complications of Low Potassium and sodium and magnesium for balance
Heal your pancreas, liver and kidney cells
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Hiccups: Natural Ways to Get Rid of Them Fast
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