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How are neurotransmitters and receptors affected in people with schizophrenia?

How are neurotransmitters and receptors affected in people with schizophrenia? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

'Jumping Genes or rogue genes ' is linked to Schizophrenia.
Risk and reward: "Jumping genes" may help ensure that every brain is unique, but could also contribute to neurological disorders such as schizophrenia.
Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation. Although Gage and colleagues have found that increased L1 is associated with mental disorders such as Rett syndrome, a form of autism, and a neurological motor disease called Louis-Bar syndrome, "no one had looked very carefully" to see if the gene might also contribute to schizophrenia, he says.
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers.
L1CAM has also been designated CD171.
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
http://www.sciencemag.org/news/2014/01/jumping-genes-linked-schizophrenia
——
In asthma, rogue genes are blocked by ADAM33.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
http://www.medicalnewstoday.com/articles/311855.php
https://en.wikipedia.org/wiki/ADAM33

How are neurotransmitters and receptors affected in people with schizophrenia?

What causes bad breath and how can it be avoided?

What causes bad breath and how can it be avoided? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Gut (intestinal) bacteria affects overall health including mouth health. Eat fermented veggies and take probiotic and prebiotics (acidophilus caps, garlic, parsley, cilantro, pineapple, papaya, kiwi).
Brushing and flossing are indeed effective ways to promote a healthy bacteria environment in your mouth, thereby preventing bad breath. However, I urge you to avoid toothpaste that contains fluoride. Rather than prevent cavities and other dental problems, fluoride is actually associated with poor oral health and a number of detrimental health risks.
Take note that tooth decay is driven by the symbiotic relationship between bacteria and acidity, which is responsible for a pathogenic environment in your mouth. Lowering the pH of your mouth will trigger loss of calcium in your teeth. Deficiency in calcium yields to low teeth porosity, which will allow plaque to become pathogenic and destroy your teeth
Use a home made mouth wash of hydrogen peroxide, baking soda and water. Brush or clean tongue.
Drink (straw) lemon water, coconut and aloe vera juice blend (home made, fresh aloe vera with apple juice). Eat red colored fruits and veggies.
Avoid sugar if possible. Do eat fruits after protein meal.

What causes bad breath and how can it be avoided?

Selda Williams honor her father Robin Williams

seldaCried reading the Instagram message of Selda Williams as tribute to her late father, Robin Williams. Since she cannot give her any birthday presents, she donated to his favorite charities instead.

Blessed are the children who love and honor their parents for they will receive more.

Blessed are those who share love and respect to each other and not hate and fear.

Blessed are those who speak the truth and not lies to get elected and serve the people well.

 

How soon after giving birth can a woman become pregnant?

How soon after giving birth can a woman become pregnant? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

Full time breastfeeding mom cannot get pregnant (4-6months later , they will) esp when they introduce other solids/foods.
It is best to allow the body to heal and recover by getting pregnant 2 yrs later.
Do not have sex during the 4-day ovulation (day 11-14), with day 1 as first day of menstruation.

How soon after giving birth can a woman become pregnant?

Why do people always ask for boiling water when helping a woman give birth?

Why do people always ask for boiling water when helping a woman give birth? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

The hot compress from boiled water as supported by the hands of midwives support the perineum of the mother to not tear so much.
I feel more pain in the hot compress on my perineum than the birth, although I felt a sharp knife pain when the baby comes out. And so I have a second degree tear at 36 yrs old (second birth). Younger mom delivers her baby with less tear (skin is richer in Vit C, A and E).
Boiling water is used by midwives for many purpose in home birth.
A compress of sage, salt and comfrey is used from the boiled water to add to the sanitary napkin which is frozen or refrigerated to be used after birth to aid in skin healing.

Why do people always ask for boiling water when helping a woman give birth?

Could a woman give birth without any help?

Could a woman give birth without any help? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

After World War II, women are heralded to birth in the hospital. During that time, laboring women are cared for near dead or infected bodies and no safety precautions were used then such as gloves so many died (sepsis).
Homebirths are advisable for healthy women who sees a CNM or OB monthly. Homebirth CNMs (midwives, bring oxygen tanks with them).
In the hospital, if the teen is perceived to have used drugs/meds, the doctors know that the baby will need to be resuscitated.

Could a woman give birth without any help?

What is the next big thing in aged care?

What is the next big thing in aged care? by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

There will be more patient centric care as the senior population are well educated in many areas of health promotion as indicated by reduction in tobacco and alcohol use and use of genetic tests.
The future seniors will be proactive since their children live in different parts of the world. Seniors will either live with their families or congregate in senior communities using the latest technologies in health monitoring and care. The future American seniors will still be bombarded with expensive medications, overly medicated, as most of them will ask their doctor to prescribe them narcotics even when not warranted as addiction to many neuro meds will remain. Only those who have savings and long term care insurance can afford personalized in home senior caregiving when needed for 24/7 care (cheaper than staying in the hospital) for chronic health care. Married senior couples live longer than singles.
A robotic kitchen is being launched although most seniors dislike new technologies like direct TV remote control. Use of new technologies (mobile health concierge/monitoring/tools/devices) will be driven by their children who are caring for them.
Connie
——-
The reach of technological innovation continues to grow, changing all industries as it evolves. In healthcare, technology is increasingly playing a role in almost all processes, from patient registration to data monitoring, from lab tests to self-care tools.
Devices like smartphones and tablets are starting to replace conventional monitoring and recording systems, and people are now given the option of undergoing a full consultation in the privacy of their own homes. Technological advancements in healthcare have contributed to services being taken out of the confines of hospital walls and integrating them with user-friendly, accessible devices.
The following are ten technological advancements in healthcare that have emerged over the last ten years.
1. The electronic health record. In 2009, only 16 percent of U.S. hospitals were using an EHR. By 2013, about 80 percent of hospitals eligible for CMS' meaningful use incentives program had incorporated an EHR into their organizations. "For such a long time we had such disparate systems, meaning you had one system that did pharmacy, one did orders, one that did documentation," says Jeff Sturman, partner at Franklin, Tenn.-based Cumberland Consulting Group. "Integrating these systems into a single platform, or at least a more structured platform, has allowed more integrated and efficient care for patients," he says.
While the EHR has already created big strides in the centralization and efficiency of patient information, it can also be used as a data and population health tool for the future. "There's going to be a big cultural shift over the next several years of data-driven medicine," says Waco Hoover, CEO of the Institute for Health Technology Transformation in New York. "Historically, that hasn't been a big part of how medicine is practiced. Physicians go to medical school and residencies, but each organization has its own unique ways they do things. That's one of the reasons we see varied care all over the country. When data is what we're making decisions off of, that's going to change and improve outcomes of the consistency of medicine delivered."
2. mHealth. Mobile health is freeing healthcare devices of wires and cords and enabling physicians and patients alike to check on healthcare processes on-the-go. An R&R Market Research report estimates the global mHealth market will reach $20.7 billion by 2019, indicating it is only becoming bigger and more prevalent. Smartphones and tablets allow healthcare providers to more freely access and send information. Physicians and service providers can use mHealth tools for orders, documentation and simply to reach more information when with patients, Mr. Sturman says.
However, mHealth is not only about wireless connectivity. It has also become a tool that allows patients to become active players in their treatment by connecting communication with biometrics, says Gopal Chopra, MD, CEO of PINGMD, and associate professor at Duke University Fuqua School of Business in Durham, N.C. "Now I can make my bathroom scale wireless. I can make my blood pressure mount wireless. I can take an EKG and put it to my smartphone and transfer that wirelessly," he says. "mHealth has the opportunity to take healthcare monitoring out of the office, out of the lab and basically as a part of your life."
3. Telemedicine/telehealth. Studies consistently show the benefit of telehealth, especially in rural settings that do not have access to the same resources metropolitan areas may have. A large-scale study published in CHEST Journal shows patients in an intensive care unit equipped with telehealth services were discharged from the ICU 20 percent more quickly and saw a 26 percent lower mortality rate than patients in a regular ICU. Adam Higman, vice president of Soyring Consulting in St. Petersburg, Fla., says while telemedicine is not necessarily a new development, it is a growing field, and its scope of possibility is expanding.
The cost benefits of telehealth can't be ignored either, Mr. Hoover says. For example, Indianapolis-based health insurer WellPoint rolled out a video consultation program in February 2013 where patients can receive a full assessment through a video chat with a physician. Claims are automatically generated, but the fees are reduced to factor out traditional office costs. Setting the actual healthcare cost aside, Mr. Hoover says these telemedicine clinics will also reduce time out of office costs for employees and employers by eliminating the need to leave work to go to a primary care office.
4. Portal technology. Patients are increasingly becoming active players in their own healthcare, and portal technology is one tool helping them to do so. Portal technology allows physicians and patients to access medical records and interact online. Mr. Sturman says this type of technology allows patients to become more closely involved and better educated about their care. In addition to increasing access and availability of medical information, Mr. Hoover adds that portal technology can be a source of empowerment and responsibility for patients. "It's powerful because a patient can be an extraordinary ally in their care. They catch errors," he says. "It empowers the patient and adds a degree of power in care where they can become an active participant."
5. Self-service kiosks. Similar to portal technology, self-service kiosks can help expedite processes like hospital registration. "Patients can increasingly do everything related to registration without having to talk to anyone," Mr. Higman says. "This can help with staffing savings, and some patients are more comfortable with it." Automated kiosks can assist patients with paying co-pays, checking identification, signing paperwork and other registration requirements. Mr. Higman says there are also tablet variations that allow the same technology to be used in outpatient and bedside settings. However, hospitals need to be cautious when integrating it to ensure human to human communication is not entirely eliminated. "If a person wants to speak to a person, they should be able to speak with a person," he says.
6. Remote monitoring tools. At the end of 2012, 2.8 million patients worldwide were using a home monitoring system, according to a Research and Markets report. Monitoring patients' health at home can reduce costs and unnecessary visits to a physician's office. Mr. Higman offers the example of a cardiac cast with a pacemaker automatically transmitting data to a remote center. "If there's something wrong for a patient, they can be contacted," he says. "It's basically allowing other people to monitor your health for you. It may sound invasive but is great for patients with serious and chronic illnesses."
An article by Kaiser Health News, National Public Radio and Minnesota Public Radio discussed the effects a home monitoring system had on readmission rates for heart disease patients at Duluth, Minn.-based Essentia Health. The national average rate of readmissions for patients with heart disease is 25 percent, but after Essentia Health implemented a home monitoring system, the rates of readmission for their heart disease patients fell to a mere two percent. And now that hospitals are being financially penalized for readmissions, home monitoring systems may offer a solution to avoid those penalties.
7. Sensors and wearable technology. The wearable medical device market is growing at a compound annual growth rate of 16.4 percent a year, according to a Transparency Market Research report. Wearable medical devices and sensors are simply another way to collect data, which Dr. Chopra says is one of the aims and purposes of healthcare. He says sensors and wearable technology could be as simple as an alert sent to a care provider when a patient falls down or a bandage that can detect skin pH levels to tell if a cut is getting infected. "Anything we are currently using where a smart sensor could be is part of that solution," Dr. Chopra says. "We're able to take a lot of these data points to see if something abnormal is happening."
8. Wireless communication. While instant messaging and walkie-talkies aren't new technologies themselves, they have only recently been introduced into the hospital setting, replacing devices like beepers and overhead pagers. "Hospitals are catching up to the 21st century with staff communicating to one another," Mr. Higman says, adding that internal communication advancements in hospitals followed a slower development timeline since they had to account for security and HIPAA concerns.
Systems like Vocera Messaging offer platforms for users to send secure messages like lab tests and alerts to one another using smartphones, web-based consoles or third-party clinical systems. These messaging systems can expedite the communication process while still tracking and logging sent and received information in a secure manner.
9. Real-time locating services. Another growing data monitoring tool, real-time locating services, are helping hospitals focus on efficiency and instantly identify problem areas. Hospitals can implement tracking systems for instruments, devices and even clinical staff. Mr. Higman says these services gather data on areas and departments that previously were difficult to track. "Retrospective analysis can only go so far, particularly in places constantly changing like emergency departments," he says, but tracking movement with a real-time locating service can highlight potential issues in efficiency and utilization.
These tools also allow flexibility for last minute changes. "If [a physician has] an add-on case today, do they have instruments on hand, and where are [the instruments]?" he asks. At the most basic level, these services can ensure equipment and supplies aren't leaving the building, and for high-cost equipment and supplies of which hospitals may only have one or a few, being able to track their location can help verify its utilization, he says.
10. Pharmacogenomics/genome sequencing. Personalized medicine continues to edge closer to the forefront of the healthcare industry. Tailoring treatment plans to individuals and anticipating the onset of certain diseases offers promising benefits for healthcare efficiency and diagnostic accuracy. Pharmacogenomics in particular could help reduce the billions of dollars in excess healthcare spending due to adverse drug events, misdiagnoses, readmissions and other unnecessary costs.
Before a full-fledged system of pharmacogenomics comes to fruition, the healthcare industry needs a tool that can aggregate and analyze all the big data and digital health information, Mr. Hoover says. "When we really start to have the ability to study a lot of that data, it's going to transfer how we match up that information at the population, individual and macro levels," he says. "The ability to actually compare that information is going to be valuable as we move forward, making sure medications we are taking are going to work for us."
Tools for big data analysis for pharmacogenomics are still being developed, but data analytics and data aggregation for the purpose of population health may be the next big advancement on the horizon. "Understanding and connecting all these variables is going to be profound as it relates to moving forward in healthcare and designing interventions and analyzing patient populations and ultimately improving the lives and health of the American population," Mr. Hoover says.
http://www.beckershospitalreview.com/healthcare-information-technology/10-biggest-technological-advancements-for-healthcare-in-the-last-decade.html

What is the next big thing in aged care?

Criminal Justice: Does America have harsher prison sentences for the same crimes as Japan does?

Criminal Justice: Does America have harsher prison sentences for the same crimes as Japan does? by Stephen McInerney

Answer by Stephen McInerney:

TL;DR version: Yes. Emphatically so.

At first I couldn't immediately find direct comparison US-Japan sentencing data on a per-category of crime, but the numerical evidence is overwhelming (later on I found ):

– in 2009 Japan's entire prison population was 75,250. For the entire country. By US standards you might as well call that zero. For cultural reasons why Japan's is low, see [1]. (This stat already answers your question, unless we hypothesize that Japanese detection, arrest, prosecution and conviction rates are wack.)
In fact, just the US juvenile prison population alone exceeds Japan's entire.

Complete US prison population data from BJS for all years and broken out by demographic, type of prison and state are here [2]

– NYTimes ''Inmate Count in U.S. Dwarfs Other Nations’' [3]:

Criminologists and legal scholars in other industrialized nations say  they are mystified and appalled by the number and length of American  prison sentences.
Prison sentences here have become “vastly harsher than in any other  country to which the United States would ordinarily be compared,”  Michael H. Tonry, a leading authority on crime policy, wrote in “The  Handbook of Crime and Punishment.”
Indeed, said Vivien Stern, a  research fellow at the prison studies center in London, the American  incarceration rate has made the United States “a rogue state, a country  that has made a decision not to follow what is a normal Western  approach.”

Now, as to apples-to-apples comparative sentencing data (doesn't reference Japan directly):

– Gottschalk [4] reports: Life sentences have become so commonplace that about one out of eleven  people imprisoned in the United States is serving one (nearly one-third  of those is LWOP).

One prominent researcher is Amanda Solter of USF, who released a 2012 report “Cruel and Unusual: U.S. Sentencing Practices in a Global Context” [5]

[5b] press release 'U.S. Sentencing Laws Out of Step with the Rest of the World… the report compiles comparative research on sentencing laws around the  globe and documents how sentencing laws distinguish the United States  from other countries. Researchers found that the United States is in the  minority of countries using several sentencing practices, such as life  without parole, consecutive sentences, juvenile life without parole,  juvenile transfer to adult courts, and successive prosecution of the  same defendant by the state and federal government.
Conversely, sentencing practices promulgated under international law and used around  the world, such as setting 12 as the minimum age of criminal liability  and retroactive application of sentencing laws that benefit offenders ('retroactive ameliorative'),  are not systematically applied in the United States. Mandatory minimum  sentences for crimes and “three strikes” laws are used in the U.S. more  widely than elsewhere in the world.
“It has long been understood that that U.S. sentences are much longer  than those used in many other countries around the world. Our study  comprehensively compiles the available statutory evidence for that  assertion,” said Professor Connie de la Vega, Professor and Academic  Director of International Programs at the University of San Francisco  School of Law, and one of the authors of the report.

– Fleischer [6] quotes it:

“There’s a reason we have the incredible prison population that we do, and  it’s not because of higher crime,” says Amanda Solter, one of the  report’s authors who spent nearly two years studying international  sentencing laws. “It’s because of our sentencing policies—the majority  of which were implemented the last 30 years.”

– Fleischer [6] Cruel and Unusual: U.S. Sentencing Practices Vs. Everybody Else is a good concise overview of Solter's research:

The U.S. is also part of the minority group of countries—21 percent of the world’s nations-–that  allow “uncapped” consecutive sentencing like the kind that put Daniel  Vilca in prison for 154 years multiple counts of the same non-violent  crime. The vast majority of countries around the world allow for  enhanced sentencing for multiple counts of the same offense, but within  limits—with “capped” maximum sentences. In Switzerland, for example,  Vilca would have received the maximum sentence allowed for one count of  possession of child porn, and then had his sentence bumped by 50 percent  for the additional counts.

Perhaps most interesting is how the U.S. deals with retroactive application of ameliorative law—meaning  how prisoner sentences are dealt with when legislators revise the  sentencing guidelines. Unlike 66 percent of the world, the U.S. has no  law that guarantees prisoners the right to ameliorative relief once  they’ve been convicted.

'What does the U.S. have in common with South Sudan and Somalia?'
They're the only three countries in the world that haven't ratified  the U.N. Convention on the Rights of the Child.  Solter et al find that overlong sentences and prosecution of children are  two ways the U.S. is out of step with most of the rest of the world.

There’s plenty gone haywire in our sentencing laws, but  a big part of the problem is that the U.S. is categorically alone in  its propensity to lock up children. According to the report, there are  an estimated 2,594 juveniles offenders serving life without parole  sentences in the U.S. and zero in the rest of the world. “Argentina is  one of the few countries aside from the U.S. whose law allows for such  sentences,” explains Solter, “they just don’t actually sentence anyone.  And if they did, the sentence would be overturned in court.”

– Emma Chen [8] has numbers on ageing criminal populations and recidivism in US vs Japan.

and once you find where to look, it goes on and on. I'm stopping now.

[1] 'Crime and Punishment in Japan: From Re-integrative Shaming to Popular Punitivism' – Ellis, Hamai
[2] http://bjs.ojp.usdoj.gov/index.c…
[3] NYT 'Inmate Count in U.S. Dwarfs Other Nations’
[4] Days Without End: Life Sentences and Penal Reform – Marie Gottschalk, Prison Legal News
[5] “Cruel and Unusual: U.S. Sentencing Practices in a Global Context” Report
[5b] USF Press Release
[6] Cruel and Unusual: U.S. Sentencing Practices Vs. Everybody Else by Matthew Fleischer
[7] http://www.niemanwatchdog.org/in…
[8] 'Angry Gran: Mobile Game or Demographic Game-Change?'

Criminal Justice: Does America have harsher prison sentences for the same crimes as Japan does?

What are statistics and country comparisons on the rates of men or women initiating more divorces in different countries?

What are statistics and country comparisons on the rates of men or women initiating more di… by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

The number of divorced and separated women in the US is on the rise, according to a recent report by Bowling Green State University’s National Center for Marriage and Family Research (NCFMR).
The report, titled “Marriage: More Than A Century Of Change” and released on Thursday, July 18, found that 15 percent of women in the U.S. are divorced or separated today, compared with less than one percent in 1920. Researchers utilized data from the National Vital Statistics, Decennial Census, and American Community Survey in making their assessment.
Dr. Susan Brown, co-director of the NCFMR, explained in a press release that this increase is due in part to cultural changes.
“The divorce rate remains high in the U.S., and individuals today are less likely to remarry than they were in the past,” she said.
Past research has indicated that women file for divorce more often than men. According to a report titled “‘These Boots Are Made For Walking’: Why Most Divorce Filers Are Women,” published by the American Law and Economics Review in 2000, women file more than two-thirds of divorces in the U.S.
And women aren’t the only demographic divorcing more often; according to data published by the American Academy of Matrimonial Lawyers in June 2013, people over the age of 50 are ending their marriages more frequently then ever before.
http://www.huffingtonpost.com/2013/07/22/divorced-women_n_3636650.html

What are statistics and country comparisons on the rates of men or women initiating more divorces in different countries?

How can I strengthen my immune system after a long illness (not related to immune function) with natural means, not including medications?

How can I strengthen my immune system after a long illness (not related to immune function)… by Connie b. Dellobuono

Answer by Connie b. Dellobuono:

I will liken this event after recovery from birth of a new baby where the mother is fed clam soup (spinach, garlic, onions and clams) in the Philippines and in Taiwan, a chicken or beef broth (whole chicken).
Bone broth, whole foods rich in (Vit B complex, magnesium, calcium, boron, selenium, Vit E and D and zinc): meat, clams/sea food, vinegar, colored veggies, sulfur-rich foods, nuts, citrus fruits, dried fruits for Boron (raisin, prunes), fermented veggies, ginger, turmeric
Massage (oil with eucalyptus, peppermint and rosemary)
Sunshine, walk/jog (before 10am and after 3pm)
Testosterone rich foods (egg yolks, seafood, meat, raisins, banana, mushrooms)

How can I strengthen my immune system after a long illness (not related to immune function) with natural means, not including medications?