How important is a levodopa based treatment? by Connie b. Dellobuono
Answer by Connie b. Dellobuono:
Levodopa has been the gold standard for symptomatic therapy of Parkinson’s disease (PD)during the last 50 years.
But:
Still, for all the good this medication imparts, it has its limitations. For one, it unfortunately does little for the non-motor symptoms of PD. Secondly, as a consequence of its short half-life, levodopa requires frequent dosing. Even in conjunction with carbidopa, a decarboxylase inhibitor that prevents peripheral breakdown, the half-life is a mere 90 minutes and the duration of action only three to four hours. Finally, this recurrent cycle of medication kicking in and then wearing off with each administration leads to oscillations in plasma drug concentrations that, with chronic use (five to 10 years), contribute to motor complications in a good number of patients.4 Additional causative factors include higher total daily dosages of levodopa; the drug’s pulsatile, non-physiologic stimulation of degenerating neurons; and longer duration of PD.
https://www.michaeljfox.org/files/foundation/Levodopa2.0.pdf
How important is a levodopa based treatment?
Published by connie dello buono
Connie Dello Buono is based in Sunnyvale California. Her first ebook is about women's health, Birthing Ways Healing Ways and her recent one is about cancer prevention, Curated Healing Ways. She had helped women have holistic childbirth as childbirth educator, founded Motherhealth, to serve seniors in the bay area with holistic caregivers and blogs at www.clubalthea.com with more than 10,000 health and finance related posts.
Connie trains her own caregivers, which are the favorites of most bay area seniors who are home bound and alone.
She is active in the rehab and nursing facilities, volunteering on music and movement for seniors.
She is a member of Lion's club and offered scholarships to students in the Philippines.
She is active at churchinsunnyvale.us and has Fridays Bible home study in Sunnyvale using the recovery version of the Bible , free at biblesforamerica.us
She loves dancing and teaching and her courses can be found at
https://teachclub.com/@thriveafter60
She is California Life Insurance licensed providing life insurance for older adults with health issues and helping women retire safely with income for life.
at menloassetca.com , she helps with 401k rollover.
3 Benefit plans
- Mortgage protection using term life insurance to pay for mortgage balance in event of death
- Final Expense plan using Single Issue Whole Life Insurance, with cash back, disability benefit and guaranteed in the presence of health issues
- Fixed Index Annuity retirement plan for safe, accessibility, less fees, less taxes, avoids probate as it goes directly to beneficiaries, rate of return with no downside market participation.
She brings compassion and understanding to the needs of her clients, bringing holistic approach in health and life insurance. Her goal is to free families from worries especially during covid with caregivers and life insurance in the presence of health issues, especially for women.
She can be reached at 408-854-1883 , motherhealth@gmail.com
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