Source: Saarland University.

A research team led by Professor Julie Bakker at Liège University (Belgium) and Professor Ulrich Boehm at Saarland University (Germany) has made a major advancement in our understanding of how the brain controls sex. Their research results are published today in Nature Communications.

Using female mice as a model, the researchers found that a hormone in the brain, (appropriately) called kisspeptin, drives both attraction to the opposite sex and sexual behavior. They discovered that pheromones secreted by the male mouse activate these neurons which, in turn, transmit this signal to another population of neurons (gonadotropin-releasing hormone neurons) to drive attraction to the opposite sex. In parallel, they also transmit this signal to cells that produce the neurotransmitter nitric oxide to trigger sexual behavior.

“This work has provided new insight into how the brain decodes signals from the outside world and then translates these environmental cues into behavior. In many animals, sexual behavior is timed to occur with ovulation to ensure the highest possible chance of fertilization and therefore, continuation of the species. Until now, little was known about how the brain ties together ovulation, attraction and sex. Now we know that a single molecule – kisspeptin- controls all of these aspects through different brain circuits running in parallel with one another”, said Ulrich Boehm, Professor of Experimental and Clinical Pharmacology and Toxicology of Saarland University.

Taken together, these findings show that puberty, fertility, attraction and sex are all controlled by a single molecule; kisspeptin. This work opens up new and exciting possibilities for the treatment of patients with psychosexual disorders such as hyposexual desire disorder. “There are currently no good treatments available for women suffering from low sexual desire. The discovery that kisspeptin controls both attraction and sexual desire opens up exciting new possibilities for the development of treatments for low sexual desire”, explained Professor Julie Bakker, who is leading the Laboratory of Neuroendocrinology at Liège University.

Source: Friederike Meyer zu Tittingdorf – Saarland University
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Open access research in Nature Communications.
doi:10.1038/s41467-017-02797-2

Abstract

Female sexual behavior in mice is controlled by kisspeptin neurons

Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that male odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.