Organs commonly affected by haemochromatosis are the liver, heart, and endocrine glands.^[3]

Haemochromatosis may present with the following clinical syndromes:^[4]

• Cirrhosis of the liver: Varies from zonal iron deposition^[5] to fibrosis (cirrhosis).
• Diabetes due to selective iron deposition in pancreatic islet beta cells leading to functional failure and cell death.^[2][6]
• Cardiomyopathy
• Arthritis, from calcium pyrophosphate deposition in joints. The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers.^[7]
• Testicular failure
• Bronzing of the skin. This deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: “bronze diabetes”.
• Joint pain and bone pain