My answer to Should someone stop consuming sugar to prevent Alzheimer's Disease?
Answer by Connie b. Dellobuono:
Yes, as most diseases including cancer are of metabolic in origin.
Studies have revealed that the metabolic pathways of oxidative metabolism, glycolysis, and glutaminolysis preferentially fuel the cell fate decisions and effector functions of immune cells. Metabolic regulation of immune responses.
It is known since a long time that any disturbance in metabolism, like obesity, is associated with immune alteration, for example, inflammation. Feeding Our Immune System: Impact on Metabolism
Alzheimer’s as Type 3 diabetes. Alzheimer’s as an energy deficit. Alzheimer's Disease, a Type 3 Diabetes
Low-grade tissue inflammation induced by obesity can result in insulin resistance, which in turn is a key cause of type 2 diabetes mellitus. Cells of the innate immune system produce cytokines and other factors that impair insulin signalling, which contributes to the connection between obesity and the onset of type 2 diabetes mellitus. Here, we review the innate immune cells involved in secreting inflammatory factors in the obese state. In the adipose tissue, these cells include proinflammatory adipose tissue macrophages and natural killer cells. We also discuss the role of innate immune cells, such as anti-inflammatory adipose tissue macrophages, eosinophils, group 2 innate lymphoid cells and invariant natural killer T cells, in maintaining an anti-inflammatory and insulin-sensitive environment in the lean state. In the liver, both Kupffer cells and recruited hepatic macrophages can contribute to decreased hepatic insulin sensitivity. Proinflammatory macrophages might also adversely affect insulin sensitivity in the skeletal muscle and pancreatic β-cell function. http://www.nature.com/nrendo/jou…
Should someone stop consuming sugar to prevent Alzheimer's Disease?