My answer to What long-term impact has 2 months of use of atypical antipsychotic (AP) drugs on dopamine (DA) recept…
Answer by Connie b. Dellobuono:
Environmental influence (drug use), genes and individual immune system are factors to consider on how well our body can detox any drug abuse. When our body is given a drug, it tries to create homoestasis but the outside drugs are toxins that in long term use can down regulate or depress most body functions.
From Wiki:
First-generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second-generation drugs, known as atypical antipsychotics, have been developed more recently, although the first atypical antipsychotic, clozapine, was discovered in the 1960s and introduced clinically in the 1970s. The terms neuroleptic and major tranquilizer were used for older antipsychotic drugs, but are gradually dropping from use. Both generations of medication tend to block receptors in the brain's dopamine pathways, but atypicals tend to act on serotonin receptors as well.