Source: Washington Post 7-6-2017
Washington Post 7-6-2017
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• There’s no end in sight for the political crisis in the Persian Gulf. After Qatar dismissed a list of demands made by a bloc of four Arab states, the foreign ministers of Saudi Arabia, the United Arab Emirates, Egypt and Bahrain said they would maintain the month-old air, land and sea blockade of Qatar. Significantly, they did not announce any new punitive measures, nor did they relax their stance on Qatar, which they claim is backing Islamist extremists and using its influence to “sabotage” its neighbors. Doha rejects these charges. From my colleagues’ report: ”The joint statement by the four foreign ministers expressed ‘regret’ for Qatar’s refusal, which it said ‘shows a lack of seriousness in dealing with the roots of the problem.’… “Taking questions at a news conference, the ministers did not rule out that they would impose further sanctions. But they also emphasized that they intend to solve the crisis ‘peacefully.’ Their next step, the statement said, would be to hold another meeting in Bahrain, but they did not say when that would be.” • More grim scenes in Venezuela today as supporters of President Nicolas Maduro stormed the halls of the country’s National Assembly, a legislature dominated by the opposition, and beat up lawmakers and other opponents of the government. The attack left at least 15 people injured, according to opposition leaders, including one lawmaker who was rushed to the hospital with broken ribs and a head wound. From my colleagues: “The assault appeared to mark a dangerous new escalation of violence against opponents of the leftist government, although it was not the first time lawmakers have been bloodied by the pro-Maduro gangs, known as ‘colectivos.’… “The attackers were eventually cleared out of the building Wednesday by security forces using tear gas and fire extinguishers. Opposition lawmakers remained in the building. They sang the country’s national anthem and said they would continue with their legislative meetings.” • As opposition protesters continue their rather epic march to Istanbul, Turkish President Recep Tayyip Erdogan is still talking tough about the supposed threats to his rule. He gave a rare interview to the editor of German publication Die Zeit. The full thing is certainly worth the read. Here’s an interesting excerpt that dovetails with my piece earlier this week on how Erdogan’s thinking sometimes aligns with that of Trump: “ZEIT: Why would the media, which is independent in Germany, engage in anti-Turkey propaganda? What kind of interest would it have in doing so? “Erdogan: I don’t believe there is such a thing as ‘independent media’ anywhere in the world. At some level, they are all — whether print or broadcast media — dependent, either ideologically, or they are pursuing their own interests. If there were such a thing as independent media, we wouldn’t have all these problems. We see things quite clearly: They head in whichever direction the wind is blowing. The German media is no different. Nobody can say that isn’t the case. We know very well that’s how things are.” |
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A pick-up truck filled with migrants returns to the city of Agadez, Niger, after it was turned back by military checkpoints in the Sahara desert. (Javier Manzano for The Washington Post) The other graveyard Hundreds of thousands of migrants fleeing war, poverty and persecution have crossed the Tenere, a barren, Texas-sized stretch of the Sahara, over the past few years. They scrounge together life savings and bet them all on a treacherous journey — first across the Tenere; then farther into the Sahara to Libya; then the choppy seas of the Mediterranean — in hopes of a better life in Europe. The world has looked on in horror at the thousands who have died when their overloaded boats capsized at sea. And while more people do perish on that final leg, the sandy graveyard of the Tenere has claimed hundreds, if not thousands, of lives. “I think we’ve over-talked the sea and under-talked the deserts,” said Tuesday Reitano, the deputy director of the Global Initiative against Transnational Organized Crime. The Tenere is located in Niger, which, per the U.N.’s development rankings, has long held the grim position of the world’s poorest country. Smugglers in Agadez, a city on the edge of the desert that functions as a migrant transit hub, stuff people into pickup trucks and then speed through the roadless expanse for days until they reach the Libyan border, where their human cargo is dealt to new handlers. Niger’s military once escorted smugglers’ convoys to the Libyan border, raking in bribes along the way. Then, late last year, Niger began to enforce a new law criminalizing the smuggling business. Military and police officers were replaced at all desert checkpoints between Agadez and the Libyan border. Raids were conducted on migrant ghettos in Agadez, aiming to shutter the shadow smuggling economy. Halfway through 2017, it appears the strategy has succeeded only in pushing smugglers and migrants toward riskier routes where they are at lower risk of detection by security forces. “They say that very few people are coming through Agadez now, but that’s not true. People are just avoiding the checkpoints now because it is illegal,” said Ibrahim Manzo Diallo, a journalist based in Agadez. Crossing tougher terrain has increased the odds that smugglers will abandon migrants in the desert. The IOM has confirmed such 52 deaths since April — the real number is certainly many times higher. “A lot of migrants come back from the desert saying ‘I didn’t know what it was like,'” said Monica Chiriac, an IOM spokeswoman in Niger. “‘Had I known, I would have never left.'” — Max Bearak
North Korean leader Kim Jong-Un celebrating the successful test-fire of a Hwasong-14 ICBM on July 4. (Agence France-Presse/Korean Central News Agency via Korea News Service) The big question After Tuesday’s first-ever North Korean test of an intercontinental ballistic missile, the issue of how to deal with Pyongyang is back at the top of the U.S. foreign policy agenda. But President Trump’s preferred strategy has been to dump the North Korean problem in China’s lap, demanding that Beijing pressure its ally instead of Washington. Beyond that, Trump has seemingly done little planning on how to conduct diplomacy if China failed or refused — and it has mostly done the latter so far. So we asked Post national correspondent Philip Bump: How light has Trump’s thinking been on North Korea? “There are two ways you could look at Trump’s rhetoric. “One school — the one championed by Trump — holds that he was deliberately vague about his foreign policy plans so as not to tip his hand to his campaign opponents. The other school counters that Trump’s vagueness was driven not by strategy but by either incuriosity or general laxity. “On North Korea, his rhetoric almost certainly fell into the latter category. “Trump formulated his strategy on North Korea years before he ran for office, arguing that the situation should be left to China. He repeated this often on the campaign trail, fleshing out his proposal no further than to advocate for improved missile defenses for the U.S. and South Korea. “Beyond that, the argument was China, China, China. China wouldn’t contain North Korea because it didn’t respect Barack Obama, he argued at one point. Were he president, he’d use economic pressure on the Chinese to get them to intervene. “Once he became president, though, his tune changed. After meeting with Chinese President Xi Jinping, he explained that the North Korea situation wasn’t as simple as one (read: he) might have thought. He explained that he wouldn’t label China a currency manipulator (one of his favorite campaign trail threats) because the country was helping with the North Korean threat. He vacillated between praising China’s efforts and giving up on them. “The biggest tell that Trump wasn’t prepared to deal with North Korea was a tweet on January 2. Trump explained that the country was developing a nuclear weapon that could strike the U.S. but that, on his watch, “[i]t won’t happen!” This week, that promise looks awfully hollow. It was the sort of promise made by someone who is either vastly overconfident, vastly underinformed — or both.” |
Many Poles are amped up about President Trump’s visit — which may not be a great thing. Meanwhile, how is Vladimir Putin preparing for his own Trump audience? The Post takes a guess. In other Europe news, you just read about some of the horrors of the journey migrants must make in attempting to reach the continent, and Bloomberg View explains why this year’s edition of the migrant and refugee crisis is so intractable. And in Britain, some prominent Brexiteers seem to be turning against their own project.
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Near the end of August, the U.S. will experience its first total solar eclipse in almost 40 years. The best place to see it will be Hopkinsville, Kentucky, and the Wall Street Journal has more on how residents of the small town feel about the expected influx of visitors. Meanwhile, ProPublica interviews a retired Republican who served in the Wisconsin legislature for more than three decades about his views on voter identification laws, while The Independent reports on how American public schools are rethinking a cruel practice known as “lunch shaming.”
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Why I need these 20 health care specialists or care providers during my lifetime
Motherhealth LLC and Mindbodyonline are partnering up to provide you the following specialist or care providers for telehealth with access using your phone for in person or telehealth appointment. Email motherhealth@gmail.com if you are a doctor or a health care provider in the bay area to be added to the list to be available for telehealth (in person, phone, video). The expected launch date is August 1, 2017.
What are we solving?
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We need the following doctors, health care pros or care providers to help us when we are sick, feeling abnormal health symptoms, aging, be hospitalized, need surgery, post surgery, depressed, and for preventive measures like losing weight and other health concerns. Email motherhealth@gmail.com your experience with any of the following health care pros or care provider and why you think they are important and have helped you be back on your feet and in good health.
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The How of Happiness
Source: The How of Happiness
The How of Happiness
University of California professor Sonja Lyubomirsky details the things research shows the happiest people have in common.
Via The How of Happiness:
- They devote a great amount of time to their family and friends, nurturing and enjoying those relationships.
- They are comfortable expressing gratitude for all they have.
- They are often the first to offer helping hands to coworkers and passersby.
- They practice optimism when imagining their futures.
- They savor life’s pleasures and try to live in the present moment.
- They make physical exercise a weekly and even daily habit.
- They are deeply committed to lifelong goals and ambitions (e.g., fighting fraud, building cabinets, or teaching their children their deeply held values).
- Last but not least, the happiest people do have their share of stresses, crises, and even tragedies. They may become just as distressed and emotional in such circumstances as you or I, but their secret weapon is the poise and strength they show in coping in the face of challenge.
Alzheimer’s and Parkinson’s Spurred By Same Enzyme
Summary: Researchers have implicated an enzyme that appears to make both Tau and alpha synculein more toxic in Alzheimer’s and Parkinson’s disease. Inhibiting this enzyme has already proved helpful in treating animal models of Alzheimer’s disease. The researchers report they are moving on to testing drugs that inhibit AEP in animal models of Parkinson’s disease.
Source: Emory Health Sciences.
AEP protease acts on amyloid, tau and now alpha-synuclein.
Alzheimer’s disease and Parkinson’s disease are not the same. They affect different regions of the brain and have distinct genetic and environmental risk factors.
But at the biochemical level, these two neurodegenerative diseases start to look similar. That’s how Emory scientists led by Keqiang Ye, PhD, landed on a potential drug target for Parkinson’s.
In both Alzheimer’s (AD) and Parkinson’s (PD), a sticky protein forms toxic clumps in brain cells. In AD, the troublemaker inside cells is called tau, making up neurofibrillary tangles. In PD, the sticky protein is alpha-synuclein, forming Lewy bodies.
Ye and his colleagues had previously identified an enzyme (asparagine endopeptidase or AEP) that trims tau in a way that makes it more sticky and toxic. Drugs that inhibit AEP have beneficial effects in Alzheimer’s animal models.
In a new Nature Structural and Molecular Biology paper, Emory researchers show that AEP acts in the same way toward alpha-synuclein.
“In Parkinson’s, alpha-synuclein behaves much like Tau in Alzheimer’s,” Ye says. “We reasoned that if AEP cuts Tau, it’s very likely that it will cut alpha-synuclein too.”
A particular chunk of alpha-synuclein produced by AEP’s scissors can be found in samples of brain tissue from patients with PD, but not in control samples, Ye’s team found.
In control brain samples AEP was confined to lysosomes, parts of the cell with a garbage disposal function. But in PD samples, AEP was leaking out of the lysosomes to the rest of the cell.
The researchers also observed that the chunk of alpha-synuclein generated by AEP is more likely to aggregate into clumps than the full length protein, and is more toxic when introduced into cells or mouse brains. In addition, alpha-synuclein mutated so that AEP can’t cut it is less toxic.
Ye cautions that AEP is not the only enzyme that cuts alpha-synuclein into various toxic pieces, and the full-length alpha-synuclein protein is still able to aggregate and cause harm. Nevertheless, he says his team is moving on to testing drugs that inhibit AEP in Parkinson’s animal models.
ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE
First author Zhentao Zhang, MD, PhD, a former postdoc with Ye, is now at Wuhan University in China.
At Emory, the laboratories of P. Michael Iuvone, PhD in the Department of Ophthalmology and Nick Seyfried, PhD in the Department of Biochemistry contributed to the paper. Lingjing Jin, MD at Shanghai Tongji Hospital and Jian-Zhi Wang, MD, Key Laboratory of Ministry of Education of China for Neurological Disorders also contributed to the paper.
Funding: The research was supported by the Michael J. Fox Foundation, the National Natural Science Foundation of China and the National Eye Institute (P30EY006360 and R01EY004864).
Source: Holly Korschun – Emory Health Sciences
Image Source: NeuroscienceNews.com image is credir=ted to From Zhang et al NSMB (2017).
Original Research: Abstract for “Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease” by Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang, Li He, P Michael Iuvone, Duc M Duong, Nicholas T Seyfried, Matthew J Benskey, Fredric P Manfredsson, Lingjing Jin, Yi E Sun, Jian-Zhi Wang & Keqiang Ye in Nature Structural & Molecular Biology. Published online July 3 2017 doi:10.1038/nsmb.3433
CITE THIS NEUROSCIENCENEWS.COM ARTICLE
Emory Health Sciences “Alzheimer’s and Parkinson’s Spurred By Same Enzyme.” NeuroscienceNews. NeuroscienceNews, 3 July 2017.
<http://neurosciencenews.com/alzehimers-parkinsons-aep-7018/>.
<http://neurosciencenews.com/alzehimers-parkinsons-aep-7018/>.
Abstract
Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease
Aggregated forms of α-synuclein play a crucial role in the pathogenesis of synucleinopathies such as Parkinson’s disease (PD). However, the molecular mechanisms underlying the pathogenic effects of α-synuclein are not completely understood. Here we show that asparagine endopeptidase (AEP) cleaves human α-synuclein, triggers its aggregation and escalates its neurotoxicity, thus leading to dopaminergic neuronal loss and motor impairments in a mouse model. AEP is activated and cleaves human α-synuclein at N103 in an age-dependent manner. AEP is highly activated in human brains with PD, and it fragments α-synuclein, which is found aggregated in Lewy bodies. Overexpression of the AEP-cleaved α-synuclein1–103 fragment in the substantia nigra induces both dopaminergic neuronal loss and movement defects in mice. In contrast, inhibition of AEP-mediated cleavage of α-synuclein (wild type and A53T mutant) diminishes α-synuclein’s pathologic effects. Together, these findings support AEP’s role as a key mediator of α-synuclein-related etiopathological effects in PD.
“Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson’s disease” by Zhentao Zhang, Seong Su Kang, Xia Liu, Eun Hee Ahn, Zhaohui Zhang, Li He, P Michael Iuvone, Duc M Duong, Nicholas T Seyfried, Matthew J Benskey, Fredric P Manfredsson, Lingjing Jin, Yi E Sun, Jian-Zhi Wang & Keqiang Ye in Nature Structural & Molecular Biology. Published online July 3 2017 doi:10.1038/nsmb.3433
Trump’s own Department of Health and Human Services: Obamacare “working as intended”, not failing
- Journalist who revealed Neo-Nazi creator of Trump’s CNN tweet now receiving death threats
- Two gaping holes recently emerged in Siberia accompanied by explosions with billowing smoke and fire
- Trump is deranged but 42 percent of Republicans say ‘freedom of the press’ is out of control
- The citizens WILL be heard from
- Donald Trump has a ‘Tell’
- Trump’s cake diplomacy collapses, he gives up on China as North Korea targets ‘American bastards’
- Trump wanders around looking for limo after deplaning
- The myth of guest workers’ threat to US jobs is coming home to roost in Trump country
- Trump’s own Department of Health and Human Services: Obamacare “working as intended”, not failing.
- Did Kris Kobach violate the Hatch Act? Attorneys launch lawsuit regarding the violation.
- Daily Kos is prepared to resist Trump every single day for the next four years and beyond. Can you chip in $1 to support independent, progressive media?
- Stop Trumpcare in the Senate: Call the Capitol Hill switchboard at 202-224-3121. Tell your Republican senators to vote NO. Tell your Democratic senators to shut down the Senate. After you are done, tell us how it went.
- After ignoring Pride Month, Trump appoints anti-trans activist to Gender Equality position
- Ethics watchdog at Justice Department resigns over Trump’s corruption
- Michael Cohen pushed out of Trump’s inner circle, into center of FBI investigation
- Trumpists triggered by the Declaration of Independence… because god-emperor Trump
- Frederick Douglass: a thorn in Lincoln’s side, and his partner. Plus his fiery July 5, 1852 speech
- Trump ‘patriot’ accidentally shot himself at Confederate rally by resting his flag pole on his gun
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Inviting all bay area doctors and alternative health care pros for mobile health app concierge
Inviting all bay area doctors and alternative health care pros for mobile health app concierge
Inviting all bay area doctors and alternative health care pros for mobile health app concierge
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Trump has never had a plan for dealing with North Korea
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States push back on Trump voter fraud commission
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