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Parasites as causative agents of mood disorders

Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii’s ability to alter host behaviour.

Webster JP¹, Lamberton PH, Donnelly CA, Torrey EF.

Author information

1Department of Zoology, University of Oxford South Parks Road, Oxford OX1 3SY, UK. joanne.webster@imperial.ac.uk

Abstract

With increasing pressure to understand transmissible agents, renewed recognition of infectious causation of both acute and chronic diseases is occurring. Epidemiological and neuropathological studies indicate that some cases of schizophrenia may be associated with environmental factors, such as exposure to the ubiquitous protozoan Toxoplasma gondii.

Reasons for this include T. gondii’s ability to establish persistent infection within the central nervous system, its ability to manipulate intermediate host behaviour, the occurrence of neurological and psychiatric symptoms in some infected individuals, and an association between infection with increased incidence of schizophrenia.

Moreover, several of the medications used to treat schizophrenia and other psychiatric disease have recently been demonstrated in vitro to possess anti-parasitic, and in particular anti-T. gondii, properties. Our aim here was thus to test the hypothesis that the anti-psychotic and mood stabilizing activity of some medications may be achieved, or at least augmented, through their in vivo inhibition of T. gondii replication and invasion in infected individuals.

In particular we predicted, using the epidemiologically and clinically applicable rat-T. gondii model system, and following a previously described and neurologically characterized ‘feline attraction’ protocol that haloperidol (an anti-psychotic used in the treatment of mental illnesses including schizophrenia) and/or valproic acid (a mood stabilizer used in the treatment of mental illnesses including schizophrenia), would be, at least, as effective in preventing the development of T. gondii-associated behavioural and cognitive alterations as the standard anti-T. gondii chemotherapeutics pyrimethamine with Dapsone.

We demonstrate that, while T. gondii appears to alter the rats’ perception of predation risk turning their innate aversion into a ‘suicidal’ feline attraction, anti-psychotic drugs prove as efficient as anti-T. gondii drugs in preventing such behavioural alterations. Our results have important implications regarding the aetiology and treatment of such disorders.

https://www.ncbi.nlm.nih.gov/pubmed/16627289

L-arginine metabolites contribute to parasite elimination

Nitric oxide (NO) is an important effector molecule of the immune system in eliminating numerous pathogens. Peritoneal macrophages fromTrypanosoma brucei brucei-infected mice express type II NO synthase (NOS-II), produce NO, and kill parasites in the presence ofl-arginine in vitro. Nevertheless, parasites proliferate in the vicinity of these macrophages in vivo. The present study shows thatl-arginine availability modulates NO production.

Trypanosomes use l-arginine for polyamine synthesis, required for DNA and trypanothione synthesis. Moreover, arginase activity is up-regulated in macrophages from infected mice from the first days of infection. Arginase competes with NOS-II for their common substrate, l-arginine. In vitro, arginase inhibitors decreased urea production, increased macrophage nitrite production, and restored trypanosome killing. In vivo, a dramatic decrease inl-arginine concentration was observed in plasma from infected mice.

In situ restoration of NO production and trypanosome killing were observed when excess l-arginine, but notd-arginine or l-arginine plusN ω-nitro-l-arginine (a NOS inhibitor), was injected into the peritoneum of infected mice. These data indicate the role of l-arginine depletion, induced by arginase and parasites, in modulating the l-arginine–NO pathway under pathophysiological conditions.

Arginine Consumption by the Intestinal Parasite Giardia intestinalis …

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446895/

Sep 19, 2012 – Arginine Consumption by ADI Since Giardia ADI is the enzyme consuming arginine within the parasite and it is also released increased upon interaction with host cells, special attention was given to this protein.

‎Introduction · ‎Materials and Methods · ‎Results · ‎Discussion

l-Arginine Availability Modulates Local Nitric Oxide Production … – NCBI

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC98402/

Moreover, parasites use l-arginine in their polyamine metabolism. All these elements contribute to a decrease in plasma l-arginine in T. b. brucei-infected mice. This decrease in l-arginine, previously reported for Trypanosoma brucei gambiense-infected voles (30), may reduce NO production and alter parasite killing.

‎Abstract · ‎MATERIALS AND METHODS · ‎RESULTS · ‎DISCUSSION

Trypanosomatid Infections: How Do Parasites and Their … – Frontiers

https://www.frontiersin.org/articles/10.3389/fimmu.2018.00778/full

Apr 20, 2018 – Depending on the environmental factors and immune response elements, L-arginine metabolites contribute to parasite elimination, mainly …

L-Arginine Availability Modulates Local Nitric Oxide Production and …

https://iai.asm.org/content/68/8/4653.full-text.pdf

(NOS-II), produce NO, and kill parasites in the presence of L-arginine in vitro. … These data indicate the role of L-arginine depletion, induced by arginase and.

The role of arginine and arginine-metabolizing enzymes during …

https://bmcmicrobiol.biomedcentral.com/articles/10…/1471-2180-13-256

Nov 14, 2013 – Giardial arginine consumption suppresses NO production and the NO-degrading parasite protein flavohemoglobin is up-regulated in response …

L-arginine supplementation reduces mortality and improves disease …

https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd…

Jan 16, 2018 – Moreover, L-arginine supplementation decreased parasitemia and heart parasiteburden, improving clinical score and survival. Nitric oxide …

‎Author summary · ‎Methods · ‎Results · ‎Discussion

Proline: fuel for parasites, worms, bacteria, fungi. | MalariaWorld

https://malariaworld.org/blog/proline-fuel-parasites-worms-bacteria-fungi

Arginases in parasitic diseases – Cell Press

https://www.cell.com/trends/parasitology/…/S1471-4922(02)00010-7.pdf?…

different parasites escape nitric oxide (NO) toxicity is the activation of arginase. This leads to a depletion of L-arginine (substrate of NO synthase, resulting.

(PDF) L-Arginine Availability Modulates Local Nitric Oxide Production …

https://www.researchgate.net/…/24500511_L-Arginine_Availability_Modulat…

Jun 22, 2018 – Nevertheless, parasites proliferate in the vicinity of these macrophages in vivo. The present study shows thatl-arginine availability modulates …

Sequestration and metabolism of host cell arginine by the …

https://onlinelibrary.wiley.com/doi/full/10.1111/cmi.12552

by SA Cobbold – ‎2016 – ‎Cited by 14 – ‎Related articles

Dec 3, 2015 – Here, we show that following invasion by the malaria parasite Plasmodium falciparum the arginine pool in the host erythrocyte compartment is …

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We provide accurate, up-to-date, and reliable information that is easy to understand and free of charge. Our trained information specialists provide personalized responses to a range of cancer questions, including:

tailored clinical trials searches
cancer research
how to find cancer treatment centers
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diagnosis and treatment
living with cancer
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CIS can also help you quit smoking. The Smoking Quitline number is 1-877-44U-QUIT (1-877-448-7848). The service is available in English and Spanish, Monday through Friday, 9 a.m. to 9 p.m. ET.

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Coping with sundown syndrome for seniors at home with caregivers

Coping with sundown syndrome for seniors at home with caregivers:

Keep the home well lit in the evenings. Provide adequate lighting to lessen shadows when it begins to get dark. Since fading light can be a trigger, maintaining a well lit environment can minimize the change in behavior.
Keep your loved one active and distracted at the time when sundowning may occur. For example, have them help prepare dinner, set the table, or take on another simple task at that time.
Create a safe and comfortable sleeping environment. Keep the room temperature moderate for sleeping and provide nightlights (if desired) and any other security means to help the person with dementia feel safe, reducing agitation.
Stick to a strict and predictable schedule. Maintaining a daily schedule is key to keeping a healthy sleep pattern, reducing the likelihood for sundowning later in the day. In addition, planning regular exercise or activities during the day (such as brisk walks, the stationary bike, or social day programs) may reduce restlessness at night.
Avoid stimulants. Alcohol, coffee, soda, and nicotine can all interfere with sleep cycles, especially for those experiencing dementia.
Keep a journal. Record the times when sundowning occurs—this can help you pinpoint triggers and determine which strategies help to ease them.
Surround the person with dementia with familiar and comforting things. Whether it is a comfortable chair, pictures of loved ones, favorite music, or a particular smell (lavender, pine, etc.), these items may ease agitation or disorientation.
Talk to a professional. If symptoms of sundowning are impacting quality of life for you and the person you care for, consider seeking a professional dementia care consultation. Dementia care experts can help you determine underlying causes of sundowning and to put new strategies in place to reduce challenging behaviors.
Have apple slices for snacks. Hydrate with warm drink of ginger, cranberry and lemon.
Apply lotion or oil with lavender and eucalyptus to legs and arms.

Eddie Glaude rips the mask off white America

Next Democratic Debate Julián Castro, Tulsi Gabbard, Kirsten Gillibrand and Tom Steyer

These Four Candidates Are Scrambling to Make the Cut for the Next Democratic Debate

Julián Castro, Tulsi Gabbard, Kirsten Gillibrand and Tom Steyer are getting closer to qualifying, and they’re urgently seeking supporters who can help them earn a spot onstage.

Image

CreditCreditChristopher Lee for The New York Times

By Matt Stevens

With the deadline to qualify for the next Democratic presidential debates looming just two weeks away, candidates on the bubble are mounting some of their final offensives, urgently seeking supporters who can help them make the cut.

Senator Kirsten Gillibrand of New York has poured more than $1 million into advertising in Iowa and New Hampshire. Julián Castro, the former housing secretary, bought a local ad in Bedminster, N.J., where President Trump is vacationing this week. And Representative Tulsi Gabbard of Hawaii has urged her supporters to try to improve their chances of being selected for online polls.

They and other lower-tier candidates are desperately searching for voters who can propel them to 2 percent support in qualifying polls, one of the Democratic National Committee’s requirements for the next set of debates, scheduled for Sept. 12 and 13 in Houston. The threshold for the June and July debates was merely 1 percent.

[Andrew Yang became the ninth Democrat to qualify for the September debates.]

Meanwhile, Tom Steyer, the former hedge fund investor turned impeachment activist, has spent millions of dollars flooding the internet with ads that have helped him catch up to his rivals after entering the race in July. On Tuesday his campaign announced that he had crossed the other threshold for qualification by collecting donations from more than 130,000 people.

The collective scramble to earn a spot on the stage next month underscores the importance the campaigns are placing on the next debates. Those who secure a lectern will have another opportunity to speak to a national audience, but those who miss out will face louder calls to withdraw as Democrats grow anxious for the field to narrow.

Senator Kirsten Gillibrand began an advertising campaign in Iowa and New Hampshire over the weekend. — CreditMaddie McGarvey for The New York Times

“This is the brave new world of D.N.C. debate qualification standards,” said Jim Hobart, a partner at Public Opinion Strategies, a Republican polling firm. “Democratic presidential candidates are clearly going to do whatever they can to qualify for these debates, whether that’s spending millions of dollars on television ads or encouraging donors to sign up for these online polls.”

A New York Times analysis of polling and donation data shows that nine of the 24 Democratic candidates have already qualified for the next debates by collecting donations from at least 130,000 people and reaching 2 percent support in four qualifying polls. The deadline to meet those standards is Aug. 28.

Mr. Castro, Ms. Gabbard, Ms. Gillibrand and Mr. Steyer are all within striking distance. Mr. Castro and Mr. Steyer need only one more qualifying poll; Ms. Gabbard needs three more; and Ms. Gillibrand needs about 30,000 more donors as well as three more qualifying polls.

None of the other candidates except former Gov. John Hickenlooper of Colorado have hit 2 percent in any qualifying polls, and Mr. Hickenlooper had only about 14,000 individual donors as of June 30. The Times reported this week that he was considering dropping out of the race.

[These three cities are key for 2020 Democrats. They’re not in Iowa or New Hampshire.]

The campaigns are not necessarily seeing a return on their investment as they hunt for new donors; many are asking for $1 contributions. But the size of the donations does not matter for debate qualification, only the number of individual contributors. That has skewed campaigns’ strategies and encouraged them to create advertising they hope will go viral.

Mr. Castro’s new advertisement is set to appear Wednesday on Fox News in Bedminster, where Mr. Trump is staying at his golf course. In the ad, Mr. Castro speaks directly to the president, ticking off Mr. Trump’s words and actions that he says “stoked the fire of racists” and inspired the mass shooting that killed 22 people in El Paso this month.

“Innocent people were shot down because they look different from you. Because they look like me. They look like my family,” Mr. Castro says in the ad. “Words have consequences.”

Mr. Castro’s campaign said it spent $2,775 to run the ad a few times on Wednesday. His team said the ad was meant to send a message to Mr. Trump, who watches Fox News regularly, but campaign officials also expected it would resonate with voters.

Ms. Gillibrand’s new 30-second ad, titled “Imagine,” paints her as “a leader driven by compassion, brave enough to take on the impossible, who looks beyond herself to do what’s best for us.” Her campaign said the ad spending was intended in part to “bolster the campaign’s efforts to qualify for the fall debates.”

Ms. Gillibrand’s campaign had more than $8 million on hand at the end of June, and her aides have said that the 24 hours after the July debate were her strongest of the campaign in terms of bringing in new online donors and contributions.

She has spent heavily since then. Over the past month, her campaign spent $1 million on Facebook ads, according to data from the company, second only to Mr. Steyer’s campaign during that period.

Representative Tulsi Gabbard has been urging her supporters to take part in polls that could help her meet the qualification threshold. — CreditMaddie McGarvey for The New York Times

Mr. Steyer’s team has said he plans to spend at least $100 million on the race. His campaign has already spent about $3 million advertising on Facebook and $820,000 on Google, according to data from those companies.

In the seven-day period ending on Sunday, he spent $1.1 million on Facebook, roughly five times as much as the second highest-spending Democratic candidate in that period, Mayor Pete Buttigieg of South Bend, Ind. On Sunday alone, Mr. Steyer spent about $140,000 on Facebook — more than what many candidates, including Senator Kamala Harris of California and former Representative Beto O’Rourke of Texas, spent on the platform in the past month.

Mr. Steyer has also spent about $6.5 million on television advertising since he hit the trail, according to Medium Buying, a Republican media buying agency.

A spokesman for Mr. Steyer’s campaign declined to comment on its spending and the amount of money it had raised in contributions. But other campaigns took note that Mr. Steyer had reached the donor threshold so quickly.

“The D.N.C. donor requirement may have been added with the right intentions, but there’s no doubt that it’s created a situation in which billionaires can buy their way onto the debate stage,” Gov. Steve Bullock of Montana said in a statement on Tuesday. “We’re kidding ourselves if we’re calling a $10 million purchase of 130,000 donors a demonstration of grass-roots support.”

Tom Steyer, the former hedge fund investor, has spent millions of dollars flooding the internet with ads. — CreditErin Schaff/The New York Times

Ms. Gabbard — who left the campaign trail this week to report for a two-week training exercise with the National Guard — is in need of better polling results. In an effort to improve those prospects, her team sent an email to supporters this month imploring them to “take the time to answer if you receive a call from a pollster or are presented with an online poll.”

The email also listed “ways you can increase your chances of being selected for a debate-qualifying poll.” It encouraged supporters to fill out surveys from the online polling firms Survey Monkey and YouGov in an effort to be selected for their presidential primary polls.

Doug Rivers, YouGov’s chief scientist, said in an email that he and his team were aware of messages like the one sent by the Gabbard campaign. But he said the company’s systems made it extremely unlikely that a newly registered respondent would be surveyed in a qualifying poll. Even then, he said, there would be too few new panelists to skew the results.

A spokeswoman for Survey Monkey said it randomly selects its respondents and prevents those selected from responding multiple times.

Thomas Kaplan contributed reporting.

Matt Stevens is a political reporter based in New York. He previously worked for The Los Angeles Times, covering drought, water and the city’s west side. @ByMattStevens

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In late 50s and wanted to know if cancer will strike the body years from now

No one knows but you can observe your body every day. Do get adequate night time sleep. In the internet, cancer signs shows up in late stage (lose of weight and appetitie and chronic – cough, pain, etc) . Early signs can be skin allergies, heartburn, bloating and back pain.

So, do eat whole foods, exercise, drink clean water, get fresh air and avoid toxins, parasites, molds, fungus, left over foods and do wash your veggies with vinegar water and salt.

skin diseases, asthma, hypertension

Born on 08/02/1951 with incomplete Pyloric stenosis which became complete in 1976. After the surgical intervention , I have had a normal live. With aging process, I am experiencing a lot of different medical problems such food allergies, skin diseases, asthma, hypertension, generalized discomfort,hypercholesterolrmia . I consider this as a natural course of my life. I am under medical treatment, and life goes on. What do you think about it?

Hi,

I would visit a regular and also a naturopathic doctor.

And follow an anti-parasitic diet. Do a liver detox. Boil fresh ginger tea. Add vitamin B complex, zinc and calcium/magnesium supplements at night and vitamin C.

Blessings,
Connie

Pancreas health issues

Pancreas issues. Waiting for MRI results Fibromyalgia, diabetes, cyst in tailbone Panic attacks, headaches, cold and burning feet. Hearing disability, heavy constipated Right hand tendon reconstruction surgery. Slow in healing and fingers burn, pain. Still wearing hand brace at night. Need more Exercise tips. No full mobility yet. Rapid weight loss. Increase hunger. Always hungry. No weight gain Very dizzy ( med change- cypralex. Can’t fall asleep.

Dear Sir,

What did you doctor told you? Did you see your blood tests and other lab tests?

I would follow an anti-parasitic diet, do a liver detox, eat fresh pineapple and warm ginger tea with turmeric and garlic. Get sunshine, try night time sleep with melatonin and eucalyptus massage oil with lavender essential oil. Massage body with coconut with spearmint essential oil. Add in your warm ginger tea, leaves of oregano, guava leaves and lemon grass leaves.

Blessings,

Connie

A reader is asking about pain in finger, back and pelvis

My body shape is so different than it used to be. I just turned 51 and I feel like my body has become so misshapen! Before I couldn’t gain weight for anything, now my I’ve been gaining weight in my belly, inner thighs, back and upper arms arms! My skin is dry and creppy looking all the time, the skin on my face is drooping and it just feels like I have a lot of loose skin on my face, I have way more cellulite than before and a lot more peach fuzz on my face and I have a crease on each ear lobe. My hair is thinning and I have a lot of pain in my fingers, my back and pelvis area down to my knees on my backside. The pain is excruciating! I have no energy whatsoever and just to go from my bedroom to the bathroom my whole body burns! I can’t seem to focus on much either! My brain isn’t as sharp as it once was to. Am I needing something in my diet? Is it cancer? Do I have a vitamin deficiency? I don’t know. B

Dear Barbara,

Go see your doctor and have a blood tests and other tests. Cancer shows up in skin as allergies, pain and other issues. I do not know what is happening to your body. Whole foods, sunshine, ginger, turmeric, detox from parasites, fresh air, massage, and other healing ways can help but you need to see the other hidden issues.

blessings,

Connie

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Free Argentine Tango lessons to people with Parkinson Disease

FREE to people with Parkinson Disease and their families.

Stanford Neuroscience Health Ctr
Wellness Ctr, Rm 1511

213 Quarry Road

Palo Alto, CA

Map

Wednesday afternoons (2:15 pm to 3:45pm)
Supported by the American Parkinson Disease Association, this class—for people with Parkinson and their families—teaches Argentine Tango as an exercise for improving movement and balance. Through musicality and movement of Tango patterns, you learn to become more aware of your center of balance and body movement while enjoying the dance.

Students must be able to walk onto the dance floor to join the class. No previous experience in Tango or other dance is necessary. No partner necessary. Walk-ins welcome. For information call (650) 721-8500.

Instructors are DVIDA-certified and experienced tango dancers.

More info on this event’s sponsor: www.apdaparkinson.org

Keywords: drop-in classes; Santa Clara County (South Bay), CA
If anything here is inaccurate, please correct it.

https://www.tangomango.org/index.php?show=San_Francisco,CA+Alameda,CA+San_Mateo,CA+Santa_Clara,CA+Marin,CA+Contra_Costa,CA+Sacramento,CA+Santa_Cruz,CA+Monterey,CA+Sonoma,CA+Mendocino,CA+Stanislaus,CA

408-854-1883 starts at $30 per hr home care

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