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Parasites in foods

Up to nearly 10% of Americans may be infected with brain parasites found in undercooked meat. One example is the brain-invasive pork tapeworm, which is the most common cause of adult-onset epilepsy. Allergenic fish worms found in nearly two-thirds of retail fish tested can trigger allergic reactions in sensitive individuals. There have been migratory skin worms found in undercooked fish (like in sushi).

Cheese may contain mites and maggots and organ meats may contain other worms. Nearly 95% of tested retail U.S. beef (including burgers) has been found to be parasite infested. The meat industry has responded to this problem by feeding arsenic to chickens and turkeys to reduce the parasite load; this arsenic may be linked to increased cancer risk in consumers, and adding bacteria-eating viruses to meat would not help one avoid the brain parasite, toxoplasma, the second leading cause of foodborne disease-related death in the United States. Being bitten by the external parasite, a lone star tick, may result in developing an allergy to meat.

Posted byconnie dello buonoAugust 2, 2019Posted inanti-agingLeave a comment on Parasites in foods

Rope parasites, baking soda, salt, enema, fasting, eucalyptus oil and lemon

Human intestinal helminths are described in this paper. They can be over a meter long, with an irregular cylindrical shape, resembling a rope. These anaerobic intestinal “rope” parasites differ significantly from other well-known intestinal parasites. Rope parasites can leave human body with enemas, and are often mistaken for intestinal lining, feces, or decayed remains of other parasites.

Rope parasites (also feeds on blood, works at night) can attach to intestinal walls with suction bubbles, which later develop into suction heads. Walls of the rope parasites consist of scale-like cells forming multiple branched channels along the parasite’s length. Rope parasites can move by jet propulsion, passing gas bubbles through these channels. Currently known antihelminthic methods include special enemas. Most humans are likely hosting these helminths.

People with alkaline blood reaction (blood pH of 8-10) had the worst parasitic invasions, most likely due to chronic constipation caused by intestinal dysbacteriosis, which rope parasites contribute to significantly. An easy way to determine if blood has alkaline reaction is based on the eye conjunctiva colour behind the eyelid. Bright pink conjunctiva colour signifies normal blood pH, while bright red colour corresponds to alkaline blood, and pale conjunctiva corresponds to acidic blood.
Similar to Giardia, rope parasites release toxins in the intestinal tract, and the blood
stream, suppressing immune system and causing multiple symptoms in humans.

Once an adult parasite is attached to the intestinal wall, human body does not have
mechanisms to get rid of it. Rope parasite tegument releases a special slimy acrid
substance with a distinct smell. This substance helps parasites attach to the lining of the
intestines and protects them from proteolytic enzymes. It is quite possible that this slime
protects the parasites from human body immunological response.

This slime release is seasonal, and it can travel up the intestinal tract, reaching lungs and airways. One can only imagine how many microelements, vitamins and enzymes the human body is stripped off to sustain this parasitic biomass. Human body starts to lack essential nutrients, which leads to higher food consumption, resulting in obesity. These helminths themselves also contribute to the excess body weight.

While currently there’s no known pharmaceutical antihelminthics cure for the
rope parasites, dehilminthation methods include cleaning water enemas, followed by
enema with baking soda, eucalyptus oil followed by the lemon juice enema,6,7,8 and
milk enemas with salt.

Source:

Click to access 1301.0953.pdf

Posted byconnie dello buonoAugust 2, 2019August 2, 2019Posted inanti-agingLeave a comment on Rope parasites, baking soda, salt, enema, fasting, eucalyptus oil and lemon

Aspartame patent reveals E. coli feces used 

Aspartame patent reveals E. coli feces used The European patent for aspartame is now available online, and it confirms the artificial sweetener is made from the waste products of genetically modified E. coli bacteria. … They are modified to produce an especially large peptide used to create aspartame.


The Annals of Oncology in 2004 noted that more than 50 studies had been published looking at saccharin in rats. Twenty of these were “one generation” studies, meaning that they did not look at the rats’ offspring. In only one of those studies did huge amounts of saccharin produce cancer, and it was in a type of rat that is frequently infected with a bladder parasite that would leave it susceptible to saccharin-induced bladder cancer.

But “two-generation studies,” in which rats were fed lots of saccharin and their offspring were, too, found that bladder cancer was significantly more common in second-generation rats. That prompted many countries to act.

Instead, they noted that the paper stated that (1) brain cancer had become more common from 1975 to 1992 and (2) that more people had started consuming aspartame recently.

A study following people for an average of more than 14 years published last year in JAMA Internal Medicine found that those in the highest quintile of added sugar consumption had more than twice the risk of dying from cardiovascular disease than those in the lowest quintile, even after controlling for many other factors.


The accompanying editorial noted that the increased risk of death began once a person consumed the equivalent of one 20-ounce Mountain Dew in a 2,000-calorie diet, and reached more than a fourfold increase if people consumed more than one-third of their diet in added sugars.


Escherichia coli (/ˌɛʃəˈrɪkiə ˈkoʊlaɪ/),[1][2] also known as E. coli (/ˌiː ˈkoʊlaɪ/),[3] is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).[4][5] Most E. coli strains are harmless, but some serotypes can cause serious food poisoning in their hosts, and are occasionally responsible for product recalls due to food contamination.[6][7] The harmless strains are part of the normal microbiota of the gut, and can benefit their hosts by producing vitamin K2,[8] and preventing colonization of the intestine with pathogenic bacteria, having a symbiotic relationship.[9][10] E. coli is expelled into the environment within fecal matter. The bacterium grows massively in fresh fecal matter under aerobic conditions for 3 days, but its numbers decline slowly afterwards.[11]

E. coli and other facultative anaerobes constitute about 0.1% of gut microbiota,[12] and fecal–oral transmission is the major route through which pathogenic strains of the bacterium cause disease. Cells are able to survive outside the body for a limited amount of time, which makes them potential indicator organisms to test environmental samples for fecal contamination.[13][14] A growing body of research, though, has examined environmentally persistent E. coli which can survive for extended periods outside a host.[15]

The bacterium can be grown and cultured easily and inexpensively in a laboratory setting, and has been intensively investigated for over 60 years. E. coli is a chemoheterotroph whose chemically defined medium must include a source of carbon and energy.[16] E. coli is the most widely studied prokaryotic model organism, and an important species in the fields of biotechnology and microbiology, where it has served as the host organism for the majority of work with recombinant DNA. Under favorable conditions, it takes up to 20 minutes to reproduce.[17]

Posted byconnie dello buonoAugust 2, 2019August 2, 2019Posted inanti-agingLeave a comment on Aspartame patent reveals E. coli feces used 

Gut microbiome and brain health

Posted byconnie dello buonoAugust 2, 2019Posted inanti-agingLeave a comment on Gut microbiome and brain health

Tulsi Gabbard

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Tulsi Gabbard

Plastics , hormone disruptor

In Louisiana’s “Cancer Alley,” pollution from chemical plants has pushed cancer rates to 50 times the United States average.

Endocrine disruptors are chemicals that may interfere with the body’s endocrine disruptors may be found in many everyday products– including plastic bottles.

Now, residents’ lives are set to get even harder.

A proposed plastics mega-complex will spew millions of tons of pollutants tied to cancer, heart and lung disease, and other serious illnesses. 

This complex, owned by shady chemical corporation Formosa Plastics, will be one of the biggest plastic plants on earth — churning out 2.4 million tons of raw plastic a year for single-use junk like bags and straws.

Locals are battling this vast new plant, but money-hungry government officials are ignoring their demands.

On August 12, we have a huge chance to stop this plastic disaster. That’s the deadline for public comment on the air pollution permits needed to start construction. If we can show massive opposition to Formosa’s mega-polluting complex, Louisiana officials will be forced to back down.

Tell Louisiana officials: We won’t let you sacrifice our health and oceans for plastic junk. Stop Formosa Plastics now!

Everywhere Formosa Plastics goes, disaster follows.

The Taiwan-based corporation caused the worst environmental disaster in Vietnam’s history, illegally discharging chemicals that poisoned 125 miles of coastline and killed hundreds of acres of coral reef.

In Louisiana, Formosa’s sprawling complex would be located just 1 mile from an elementary school — and in the middle of St. James Parish, a low-income, mainly Black area that’s already suffering from horrific air pollution.

But Formosa isn’t invincible. Texas residents just won a huge case against Formosa for the years it illegally dumped raw plastics into waterways. The corporation must now pay up to $162 million in fines.

Add your voice: Tell Louisiana officials to vote NO on polluting, law-breaking Formosa Plastics!

Louisiana officials think this is a small, local issue. But we know it’s not. This is part of the oil and gas industry’s $180-billion plan to nearly double plastic production in the next decade — a move that could annihilate our oceans.

Luckily, the world is turning against polluting plastics. SumOfUs members like you just won historic legislation in Canada that will phase out single-use plastics. People power has pushed hundreds of other cities, states and countries to take action against plastic too.


9 Ways to Avoid Hormone-Disrupting Chemicals | NRDC


https://www.nrdc.org/stories/9-ways-avoid-hormone-disrupting-chemicals

Jan 18, 2016 – Endocrine disruptors like BPA and phthalates lurk in everything from cleaning products to fragrances. Try to steer clear of these chemicals by …

Dirty Dozen Endocrine Disruptors | EWG


https://www.ewg.org/research/dirty-dozen-list-endocrine-disruptors

Oct 28, 2013 – There is no end to the tricks that endocrine disruptors can play on our … Not all of these plastics contain BPA, but many do – and it’s better safe …

Endocrine disruptor – Wikipedia


https://en.wikipedia.org/wiki/Endocrine_disruptor

Jump to Bisphenol A (BPA) – BPA is a known endocrine disruptor, and numerous studies have found that laboratory animals exposed to low levels of it …

‎History · ‎Endocrine system · ‎Types · ‎Legal approach

Endocrine Disrupting Chemicals (EDCs) | Hormone Health Network


https://www.hormone.org/hormones-and-health/endocrine-disrupting-chemicals
What are Endocrine–Disrupting Chemicals and why should you be concerned? … Global production of plastics grew from 50 million tons in the mid-1970s to …

Health Effects of Environmental Endocrine Disrupters – EndocrineWeb


https://www.endocrineweb.com/…endocrine…/health-effects-environmental-endocrine…

Mar 20, 2019 – Ongoing exposure to endocrine disrupting chemicals like BPA lead to a number of diseases including diabetes, early onset of puberty, cancer, …

Endocrine Disrupting Chemicals (EDCs) – WHO


https://www.who.int/ceh/risks/cehemerging2/en/

Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly … on the subject in the State of the Science of Endocrine Disrupting Chemicals 2012, …

Endocrine Disruptors – Emory Department of Pediatrics


https://www.pediatrics.emory.edu/centers/pehsu/concern/disruptor.html

Endocrine disruptors (EDs) are environmental chemicals that affect the function of the … Phthalates are chemicals used as plasticizers, or plastic softeners.

What is an endocrine disruptor? – ScienceDirect


https://www.sciencedirect.com/science/article/pii/S1631069117301257
by C Monneret – ‎2017 – ‎Cited by 27 – ‎Related articles

Endocrine disrupting chemicals (EDCs) and potential EDCs are mostly man-made … EDCS may be found in plastic bottles and metal food cans (BPA), medical …

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Plastics , hormone disruptor

Healthy fats for the gall bladder

A low fat diet cannot adequately stimulate the gall bladder to release bile for fat digestion and absorption.

Polyunsaturated fats such as omega-3 seem to help keep the gallbladder healthy and reduce the risk ofgallbladder problems. These fats are commonly found in cold-water fish, nuts such as walnuts, seeds such as flaxseed, and oils from fish or flaxseed.

Parasites

Parasites residing in the biliary tree include Clonorchis sinensis, Opisthorchis viverrini, Opisthorchis felineus, and Fasciola hepatica. They are willowy, leaf-like, flat flukes dwelling in the bile ducts andgallbladder.

Several parasites infest liver or biliary tree, either during their maturation stages or as adult worms. Bile iry tree parasites may cause pancreatitis, cholecystitis, biliary tree obstruction, recurrent cholangitis, biliary tree strictures and some may lead to cholangiocarcinoma. This review discusses the hepatobiliary parasites, and shows our experience in diagnosis and management of these parasites. Ultrasonography of the liver is diagnostic in schistosomiasis, hydatid cysts, amebic liver abscess, ascariasis and other biliary tree parasites showing bile duct dilatation. Percutaneous aspiration under ultrasonography guidance of hydatid liver cysts or amebic abscess are effective measures in management. Endoscopic retrograde cholangiopancreatography (ERCP) is safe and effective in diagnosis and management of biliary tree parasites.

Gall bladder detox

  • Lemon juice and olive oil. This method involves not eating for 12 hours during the day and then, at 7 p.m., drinking four tablespoons of olive oil and one tablespoon of lemon juice — eight times every 15 minutes.
  • Apple juice and vegetable juice. This method involves drinking only apple juice and vegetable juice until 5 p.m. After 5 p.m., drink 18 milliliters (ml) of olive oil and 9 ml of lemon juice every 15 minutes until you’ve consumed eight ounces of olive oil.

Some people may also use enemas along with drinking olive oil and lemon juice to encourage bowel movements. Enemas may contain soap suds or warm water that a person instills into the rectum. The extra water can stimulate the bowels to move.

Posted byconnie dello buonoAugust 1, 2019August 1, 2019Posted inanti-agingLeave a comment on Healthy fats for the gall bladder

Guava leaves, comfrey leaves, sulfur, MSM, cellulite, diabetes and uses

guava leaf tea: Topics by WorldWideScience.org


https://worldwidescience.org/topicpages/g/guava+leaf+tea.html

In order to increase total soluble phenolics contents, guava leaves tea (GLT) was first …… Sulfurvolatiles in guava (Psidium guajava L.) leaves: possible defense …… of foxglove leaf poisoning following the use of alleged “comfrey” herbal tea.

The Medicinal Properties Of Guava And Its Leaves | Well.Org


https://www.well.org/nutrition/medicinal-guava/

 Rating: 4.5 – ‎22 votes

Jun 21, 2019 – Discover guava tree health benefits for disease prevention and overall wellness. Let’s look at all the properties locked inside this little fruit here!

Missing: sulfur ‎comfrey

(PDF) Commonly used herbs for canine dermatologic problems in the …


https://www.academia.edu/…/Commonly_used_herbs_for_canine_dermatologic_probl…

For dermatophytosis, the leaves of the following plants: eggplant, lemon grass … (picture of comfrey) Common name: comfrey Scientific name: Symphytum officinale … dermatophytosis (picture of guava) Common name: guava Scientific name: … tannin, sulfur, amygdalin Part of plant used: leavesPreparation of the herb: …

Thyme herb for toe fungus (guava and comfrey leaves and others …


https://clubalthea.com/…/thyme-and-toe-fungus-guava-and-comfrey-leaves-and-other…

Apr 11, 2013 – Another new finding from the researchers is that thyme compounds … Sulfur volatiles in guava leaves act as protection from insect vector H …

Fertilizer For Banana Tree : Fertilization Recommendation


https://www.mykitchengarden.info/2015/08/fertilizer-for-banana-tree.html

Aug 15, 2015 – I also feed my banana plant with potassium rich comfrey tea every … content in the banana fruit, banana peels and banana leaves. … The other nutrients needed for the banana production are phosphorus, magnesium, boron and sulfur. …. For Banana Tree Guava Tree : How To Grow GuavaCitrus Leaf Curl …

How To Make An Ointment – Herbalism Basics 5 – YouTube


https://www.youtube.com/watch?v=YPsJctUFfUo

 

Video for sulfur content in comfrey guava leaves▶ 5:01
Jan 15, 2011 – Uploaded by Rickvanman – Variety Channel

Herbalism Basics 5 – How To Make An Ointment. This is one of a series of 6 YouTube videos explaining the …

How does MSM help us get rid of cellulite? – Quora


https://www.quora.com/How-does-MSM-help-us-get-rid-of-cellulite

Nov 9, 2016 – Once toxins are removed by sulfur, you will see clearer skin. Once I have a skin disorder, my mom would boil guava leaves (comfrey leaves in …

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Guava leaves, comfrey leaves, sulfur, MSM, cellulite, diabetes and uses

Comfrey leaves and parasites

The genus name for comfrey is Symphytum, which means to “unite or knit together.” The name com-firma means simply, “knitting of bones.” You can use the leaf and the root, fresh or dried.   

Comfrey contains a special substance called allantoin, which is a cell proliferative. In other words, it makes cells grow faster. This is one of the reasons why comfrey-treated bones knit so fast, wounds mend so quickly and burns heal with such little scarring. Comfrey is often called knitbone or healing herb.   

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Comfrey leaves and parasites

Guave leaves and parasites

There is increasing interest in discovering new bioactive compounds derived from ethnomedicine. Preparations of guava (Psidium guajava L.) leaves have traditionally been used to manage several diseases. The pharmacological research in vitro as well as in vivo has been widely used to demonstrate the potential of the extracts from the leaves for the co-treatment of different ailments with high prevalence worldwide, upholding the traditional medicine in cases such as diabetes mellitus, cardiovascular diseases, cancer, and parasitic infections.

Moreover, the biological activity has been attributed to the bioactive composition of the leaves, to some specific phytochemical subclasses, or even to individual compounds. Phenolic compounds in guava leaves have been credited with regulating blood-glucose levels.

Thus, the aim of the present review was to compile results from in vitro and in vivo studies carried out with guava leaves over the last decade, relating the effects to their clinical applications in order to focus further research for finding individual bioactive compounds. Some food applications (guava tea and supplementary feed for aquaculture) and some clinical, in vitro, and in vivo outcomes are also included.

Conclusion

Traditional claims generally require experimental research to establish their effectiveness. In this regard, ethnomedicine applications of Psidium guajava L. leaves have been verified by several researches over the last decade against many disorders, demonstrating its potential in the treatment of the most common worldwide diseases. In addition, the effects of the leaves have been related to individual compounds such as quercetin, catechin, vescalagin, gallic acid, peltatoside, hyperoside, isoquercitrin, and guaijaverin.

Future prospects should be aimed at investigating the biodiversity of guava and/or the purification of the different compounds present in guava leaves in order to obtain functional ingredients for further uses as alternative agents in natural therapeutic approaches.

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Guave leaves and parasites

Aspirin , parasites and liver cancer

A study showed that aspirin significantly inhibited the PGHS activity as well as the motility of mf and adult parasites [5]. Aspirin, a nonsteroidal anti-inflammatory drug (NSAID) used basically to decrease pain and inflammation. However, the mode of action by which aspirin kills the parasite was not known.

Data from the study show that taking aspirinon a regular basis can lower the risk of developing liver cancer, or hepatocellular carcinoma (HCC).

The scientists defined “a regular basis” as taking two or more 325-milligram tablets per week for 5 years or more.

The study’s results are promising. “Regular use of aspirin led to significantly lower risk of developing HCC, compared to infrequent or no aspirin use, and we also found that the risk declined progressively with increasing aspirin dose and duration of use,” says lead author Dr. Tracey Simon, who is a research fellow from the Massachusetts General Hospital Division of Gastroenterology in Boston.

Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. … If you have decreased kidney function, painkillers called NSAIDs (see below) and higher dose aspirin are not recommended.

In August 2014 scientists published an analysis of previous aspirin studies. The study confirmed that aspirin can lower the risk of developing bowel, stomach and oesophageal cancers. It can also lower the risk of lung, prostate and breast cancersbut not as much as the other cancer types.

Aspirin Linked to Lower Brain Cancer Risk. In the study, researchers found that people who regularly took aspirin had a nearly 34 percent lower risk of a type of brain tumor called a glioma, compared with people who didn’t take aspirin regularly.

Posted byconnie dello buonoAugust 1, 2019August 1, 2019Posted inanti-agingTags:aspirin, cancer, parasitesLeave a comment on Aspirin , parasites and liver cancer

Patient-centric endpoint data

Deborah Collyar, President, Patient Advocates in Research (PAIR), stresses the importance of patients being at the front and center of clinical trials

Terms like “patient centric” are all the rage these days. It’s meaning, however, depends on who bandies them about, but the ways in which to effectively achieve patient centricity are in very short supply. Unfortunately, the needs of the patients are usually at the tail end of the research process rather than the beginning.

In truth, the system has focused on everything else first, before the patients. This is evident in every journal article and, frankly, in every conference – all you have to do is peruse the titles. Patients feel like afterthoughts (at best), and think system priorities create barriers to what they need and want most. Sponsors often spend a great deal more time, money and effort on endpoints, regulations, and publications than they do on learning true patient needs and issues. While the Merriam-Webster dictionary provides a generic definition for the term “centricity,” patients use a different mantra, “Nothing about us without us!”

If patient centricity is to mean anything, the research system must change terminology, mindsets, and approaches to drug and device development. Sounds like a tall order, I know, but bear with me!

I was asked to share some key points on this topic while speaking at the Arena International 8th Annual Outsourcing in Clinical Trials West Coast 2016 Conference. Our panel discussion, “Considering the growing trend of patient centricity to highlight the need for all sponsors to put patients in the centre,” included Yu Ping Yen, Vice President of Clinical Operations from Dance Biopharma, and me. We accepted the challenge to share key points and examples in 30 minutes (total), and then met later with attendees to field questions. Here is a copy of our presentation.

It is clear that we are now in a targeted medicine landscape. Targeted therapies demand that every aspect of a clinical trial also needs to be targeted, starting with patients. It is important to understand that people become patients, and they have already received conflicting messages along the medical path before being diagnosed with an illness, disease or condition. New molecular tests also complicate the issue, so learning how to find AND interest the specific patients you need becomes critical. It is also crucial to turn validated data into useful knowledge that actually brings affordable results to patients. Shortcuts that stop at “big data” can produce false information that can actually harm people instead of providing them with meaningful answers.

Back at the conference, the audience was asked what “patient” meant to them. Most nodded while seeing pictures of people in short gowns, waiting in clinics, or even as blood samples that were being analyzed by lab technicians. Clearly, the system has treated patients as disease data points or means to an end rather than key contributors who deserve respect. Instead, patients see themselves as whole people who are family members, and happen to have a disease or condition. These people are looking for answers, and they want to work with providers who can explain complicated concepts (and how it could impact) / (in context to) their daily lives.

We then ventured into different kinds of patient centricity. Yu Ping Yen provided information on diabetic care that was managed precisely with each patient during a clinical trial. Individualized plans were developed with patients after engaging discussions about lifestyle, diet, risk factors, comorbidities, and what type of support system existed for them. Discussions about modifiable risks and different types of insulin treatments were also explained to enhance the shared decision-making process.

The U.S. Food and Drug Administration (FDA) actions regarding patient centricity were also highlighted. The FDA actively seeks patient input to inform their pre-market and post-market decisions. This includes interaction at conferences, meetings, and grassroots efforts such as the Twitter #StripSafely campaign to ensure safe and accurate test strips for diabetes patients. The FDA has also had a Patient Representative Program for years that allows patient representatives to participate in pre-approval meetings with sponsors, and serve on Advisory Committees.

Other ways to incorporate patients into the development and implementation of clinical trials was presented. For instance, PAIR members have actively participated as partners and peers in clinical research since 1994. We bring reality to research by infusing patient needs and experiences into specific research dialogues, while helping to resolve barriers that hinder bringing relevant research results to patients.

Many examples of patient partnerships exist throughout the spectrum of clinical research, starting with feasibility of study designs and eligibility criteria. We also work in all phases of clinical trials and with key collaborators, including regulatory agents and IRBs, to help speed up the trial process and to minimize risk. In addition, we can develop successful recruitment plans and materials with sponsors and CROs that provide greater understanding and can impact specific communities and populations in mutually beneficial and ethical ways. Last, but certainly not least, we can create plain language study summaries that clearly explain trial results in meaningful ways to patients.

So, what does it take to build effective patient-centric clinical trials? The concepts are actually quite simple, although it takes renewed commitment to achieve them. Viewing patients (and their representatives) as valuable peers, and showing respect at each step is the key. This requires mutually agreed-upon ground rules that allow for an open exchange at each decision point, building jargon-free, reciprocal communication, and adjusting plans along the way. Sharing emerging research issues with your patient partners also ensures relevant input.

There are very few patient representatives that have clinical research expertise across the board. After all, we are no different than any other partner in the research system. Groups like PAIR know this, and can help fit the patient expertise needed for each stage of the clinical trial process.

Key points in a 30-minute conference slot may sound interesting. What we can do by bringing real patients into clinical trial design and operations, however, is create amazing advances that reflect the true meaning of patient-centered research. “Patient-centricity” means putting patient needs first, not last. We are all learning how to listen and learn together to build better products that meet patient needs for years to come.

By Deborah Collyar
President, Patient Advocates In Research (PAIR)
Deborah@tumortime.com
Twitter: @deborahcollyar
LinkedIn: http://bit.ly/1uHixTf
Blog: https://collyar.wordpress.com/

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Patient-centric endpoint data

Scrapie

Scrapie is thought to be spread most commonly from dam to offspring via infected placenta and placental fluids. Genetically-susceptible ewes and lambs in the same lambing environment are considered at-risk for developing the disease. While rams and bucks can get scrapie, they are not believed to be involved in the transmission of the disease. Semen is not known to transmit infectivity.
Other oral routes of transmission are possible. It was recently learned that infective scrapie prions can be transmitted to lambs through the milk. Soil may also serve as a reservoir for the disease. In Iceland, scrapie has re-occurred on farms that were depopulated and disinfected, as long as 16 years after the last sheep left the farm.

Feed is not considered to be a significant factor in the transmission of scrapie. Scrapie is not known to pose a human health risk.

https://www.sheepandgoat.com/updatescrapie

Scrapie of sheep and goats is endemic in most European countries and the Americas, but it is not known to exist in Australia or New Zealand [1]. Most clinical cases of scrapie occur in sheep between 2 and 5 years of age, and unlike other priondiseases, there is evidence that scrapie can be transmitted both vertically, from ewe to lamb before or shortly after birth, and horizontally, from sheep to sheep either directly or via the environment. The genetic makeup (i.e., certain polymorphismswithin the PrP gene) has a strong influence on whether an animal will develop clinical scrapie. There is no direct evidence that the infectious agent of scrapie may be transmitted to humans [12]. Nevertheless, the fact that sheep may have been exposed to BSE prions has opened the possibility that these animals could, in theory, constitute a risk to humans. This has prompted several programs aimed at eliminating scrapie from sheep flocks in the United Kingdom.

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Scrapie

Top health hacks 8-1-2019

Free ebook on cancer-free healing ways and curated health info
Aspirin is harmful to our kidneys
Philippines Coconut Wine -Tuba
Eggplant and apple cider vinegar for skin cancer
Foods to eat and avoid when you have Gout and leg pains
Salted caramelized sugar and brain opioids
Can Gout be cured permanently?
Acidic carbonated soda, bone loss and early menopause, magnesium deficiency
Signs of the preactive and active phase of dying, medications for terminally ill
Top health hacks 8-1-2019
Restore your vision naturally y Dr. Mercola
Evidence-Based Practice and Health Technology Assessment
Nitric Oxide Dump Exercise with nose breathing to lower blood pressure and thin blood
Best health topics on How To and tips about our health
Starve cancer cells with low cal ketogenic diet
DMSO, hydrogen peroxide and Vit C fight cancer cells
Immune system, bone marrow, anti-cancer, shark oil
Misdiagnosed thyroid cancers by Dr Mercola
Eggplant and apple cider vinegar for skin cancer
Drug Interaction Probability Scale – DIPS
Holistic bay area senior care , caregiver, services, health data and mission
What Causes Muscle Cramps and Spasms?
Water filtering – reverse osmosis,charcoal filtering and deionization
Bullying effect of Trump to National Health
Parasites and groin pain
Big 4 Medicare Mistakes
Canada simvastatin drug prices
Luncheon meat, nitrosamines and cancer
Caffeinated coffee and pure caffeine promote proteostasis – good for worms
Nicotine and cocaine have same effects
Cigarettes and nutrient depletion
Coming Collapse of the Middle Class with Elizabeth Warren
Mullein herb for lung and breast health – COPD signs, symptoms and diagnosis
Toxic protein, aging and wrinkled skin
Compounds That Help Protect Against Melanoma Skin Cancer
Jackfruit and cancer

Posted byconnie dello buonoAugust 1, 2019Posted inanti-agingLeave a comment on Top health hacks 8-1-2019

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