Aspirin , parasites and liver cancer

A study showed that aspirin significantly inhibited the PGHS activity as well as the motility of mf and adult parasites [5]. Aspirin, a nonsteroidal anti-inflammatory drug (NSAID) used basically to decrease pain and inflammation. However, the mode of action by which aspirin kills the parasite was not known.

Data from the study show that taking aspirinon a regular basis can lower the risk of developing liver cancer, or hepatocellular carcinoma (HCC).

The scientists defined “a regular basis” as taking two or more 325-milligram tablets per week for 5 years or more.

The study’s results are promising. “Regular use of aspirin led to significantly lower risk of developing HCC, compared to infrequent or no aspirin use, and we also found that the risk declined progressively with increasing aspirin dose and duration of use,” says lead author Dr. Tracey Simon, who is a research fellow from the Massachusetts General Hospital Division of Gastroenterology in Boston.

Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. … If you have decreased kidney function, painkillers called NSAIDs (see below) and higher dose aspirin are not recommended.

In August 2014 scientists published an analysis of previous aspirin studies. The study confirmed that aspirin can lower the risk of developing bowel, stomach and oesophageal cancers. It can also lower the risk of lung, prostate and breast cancersbut not as much as the other cancer types.

Aspirin Linked to Lower Brain Cancer Risk. In the study, researchers found that people who regularly took aspirin had a nearly 34 percent lower risk of a type of brain tumor called a glioma, compared with people who didn’t take aspirin regularly.

Aspiring and Omega 3

Aspirin and omega3 fatty acids work together to fight inflammation. … Now researchers show that aspirin helps trigger the production of molecules called resolvins that are naturally made by the body from omega3 fatty acids.Feb 21, 2013

Aspirin & Omega-3 Drug Interaction | LIVESTRONG.COM

https://www.livestrong.com › Food and Drink

People in the United States use more omega3 fatty acids than any other non-vitamin or non-mineralsupplement, according to the National Center for… … that induce blood clotting. Blood clots can cause a heart attack or a stroke, so by inhibiting blood clotting, aspirin reduces your risk of developing these conditions.

Heart Disease Prevention, Aspirin & Fish Oil | Dr. McDougall’s Health …

Purslane is the richest source of these beneficial omega3 fats of any plant yet studied. Because of that happy fact, you may find this leafy vegetable becoming a popular food item in the United States. Second-line therapy might include an aspirin tablet a day for those people at high risk for a heart attack or a stroke.

Healthy Omega-3 Fats and Aspirin Work Together to Fight Inflammation

Feb 21, 2013 – Healthy Omega3 Fats and Aspirin Work Together to Fight Inflammation. … New research published this week in the Cell Press journal Chemistry & Biology shows how the combination of omega3 fatty acids and aspirin can put up a powerful fight against inflammatory conditions likeheart disease and arthritis.

Omega-3 Supplements and Cardiovascular Diseases – NCBI – NIH

by A Mohebi-Nejad – ‎2014 – ‎Cited by 11 – ‎Related articles

One potential safety concern with omega3 supplement use is the risk for hemorrhagic stroke. At very high doses (e.g. 15 grams per day), omega3 fatty acids increase bleeding time (15).

Is It Safe to Mix Fish Oil and Blood Thinners? | Heart MD Institute – Dr …

Sep 6, 2016 – The omega3 fatty acids in fish oil help make blood platelets less likely to clot; antiplatelet blood thinners do the same thing. Too much of both can increase the risk for excessive bleeding from minor, everyday cuts or from the gastrointestinal side effects of drugs like aspirin or NSAIDs, as well as bruising or …

Aspirin and omega-3 fatty acids work together to fight inflammation …

Feb 21, 2013 – Now researchers show that aspirin helps trigger the production of molecules called resolvins that are naturally made by the body from omega3 fatty acids. These resolvins shut off, or “resolve,” the inflammation that underlies destructive conditions such as inflammatory lung disease,heart disease, and …

Should you consider taking a fish oil supplement? – Harvard Health

Dec 1, 2017 – The AHA’s earlier recommendation, published in 2002, advised people with known heartdisease to consume about a gram per day of the omega3 fatty … fish oil may increase bleeding risk, particularly in people who also take anti-clotting medications, including warfarin (Coumadin) and low-dose aspirin.

Fish Oil Vs. Aspirin – Dr. Thaddeus Gala, DC

Fish oil gets to the root cause of inflammation. Aspirin treats the symptoms of inflammation. I suggest that people take fish oil on a regular basis to help with overall heart health, and of course the many other benefits from taking Omega 3’s. To be clear – I am a bigger fan of animal based Omega 3’s such as fish or krill oil, …

Should I take aspirin even if I take omega 3 supplements daily …

Hello, the health benefits of omega3 supplements are suggested but not absolutely clear and are mainly in heart health. Aspirin therapy may be helpfu.

Heart supplements: Proceed with caution – Consumer Reports

The omega3 fatty acids in fish oil, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), appear to be most effective at lowering triglycerides, an artery-clogging fat in the blood. They might also protect the heart by slightly raising HDL (good) cholesterol, lowering blood pressure, and reducing inflammation.

Aspirin is harmful to our kidneys

Pain Medicines (Analgesics)

What are analgesics?

Analgesics are medicines that help to control pain and reduce fever, and some types also decrease inflammation. Examples of analgesics that are available over the counter are: aspirin, acetaminophen, ibuprofen, Ketoprofen and naproxen sodium. Prescription strength pain medicines are also available. Some analgesics contain a combination of painkilling ingredients in one pill- such as aspirin, acetaminophen and caffeine- that have been linked to kidney disease. These are not as readily available as in the past.

Can analgesics hurt kidneys?

Check with your doctor to be sure you can use these medicines safely, particularly if you have kidney disease. Heavy or long-term use of some of these medicines, such as ibuprofen, naproxen, and higher dose aspirin, can cause chronic kidney disease known as chronic interstitial nephritis. The warning labels on over-the-counter analgesics tell you not to use these medicines for more than l0 days for pain and more than three days for fever. If you have pain and/or fever for a longer time, you should see your doctor. The doctor can check for possible medical problems and advise you about what medications you should take.

If you have decreased kidney function, painkillers called NSAIDs (see below) and higher dose aspirin are not recommended. Even with normal kidney function, you should use analgesics:

  • Exactly as prescribed or as on the label
  • At the lowest dose possible
  • For the shortest period of time

Is aspirin safe for regular use?

When taken as directed, regular use of aspirin does not seem to increase the risk of kidney disease in people who have normal kidney function. However, taking doses that are too large (usually more than six or eight tablets a day) may temporarily- and possibly permanently- reduce kidney function. In people with kidney disease, aspirin may increase the tendency to bleed. People who already have reduced kidney function, or other health problems such as liver disease or severe heart failure, should not use aspirin without speaking to their doctor.

My doctor recommended that I take an aspirin every day to prevent heart attacks. Will this hurt my kidneys?

No. There is no evidence of risk regarding the regular use of aspirin in the small doses recommended for prevention of heart attacks. Use of a ‘baby aspirin’ (81-162 mg daily) is fine, even with reduced kidney function.

What analgesics are safe for people who have kidney disease?

Acetaminophen remains the drug of choice for occasional use in patients with kidney disease because of bleeding complications that may occur when these patients use aspirin. However, kidney patients who need to use acetaminophen habitually should be supervised by their doctors and be sure to avoid drinking alcohol while on this medicine.

What are NSAIDs? Are they safe to take?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a specific group of pain relievers. Some NSAIDs are available over the counter. This includes different brands of ibuprofen, naproxen sodium and ketoprofen.

NSAIDs are usually safe for occasional use when taken as directed, but if you have known decreased kidney function, they should be avoided. These medications should only be used under a doctor’s care by patients with kidney disease, heart disease, high blood pressure or liver disease or by people who are over 65 or who take diuretic medications. NSAIDs may cause an increased risk of sudden kidney failure and even progressive kidney damage.

I have arthritis. What pain relievers can I take that won’t hurt my kidneys?

You should speak to your doctor about the best choice for you. In addition, if you have any of the medical conditions listed in the previous question, you should only use NSAIDs under your doctor’s supervision.

How do I know if analgesics have affected my kidneys?

Your doctor can check your kidneys by doing a simple blood test called a serum creatinine level. This test measures the amount of a waste product in your blood that is normally removed by your kidneys. If your kidneys are not working as well as they should, the creatinine level will be increased in your blood. The results of the serum creatinine test can be used to estimate your glomerular filtration rate (GFR). Your GFR number tells your doctor how much kidney function you have.

A urine test for the presence of protein may also be done. Persistent protein in the urine may be an early indication of kidney damage.

Are there other side effects from taking aspirin and NSAIDs?

Yes. The development of stomach ulcers and gastrointestinal bleeding has been the most common serious side effect from taking NSAIDs and aspirin. NSAIDs also increase the risk of heart attack and stroke.

What can I do to keep my kidneys healthy?

Kidney disease caused by analgesics is often preventable Here are some things you can do to help keep your kidneys healthy.

  • Do not use over-the-counter pain relievers more than 10 days for pain or more than three days for fever. If you have pain or fever for a longer time, you should see your doctor
  • Avoid prolonged use of analgesics that contain a mixture of painkilling ingredients, like aspirin, acetaminophen and caffeine mixtures in one pill
  • If you are taking analgesics, increase the amount of fluid you drink to six to eight glasses a day
  • If you are taking analgesics, avoid drinking alcohol
  • If you have kidney disease, consult your doctor before taking an analgesic, particularly NSAIDs and higher dose aspirin.
  • Use NSAIDs under your doctor’s supervision if you have heart disease, high blood pressure, kidney disease or liver disease or if you take diuretic medications or are over 65 years of age
  • Make sure your doctor knows about all medicines you are taking, even over-the-counter medicines
  • Make sure you read the warning label before using any over-the-counter analgesics.

Para-inflammation can drive the formation of tumors, aspirin stops it

A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don’t display typical signs of inflammation.

 A team led by researchers in the labs of Atul Butte, MD, PhD, director of the Institute for Computational Health Sciences and a professor of pediatrics at UC San Francisco, and Yinon Ben-Neriah, MD, PhD, a professor of immunology and cancer research at the Lautenberg Center of Immunology of Hebrew University Medical School in Jerusalem, identified the role of a subtle form of inflammation in human and mouse cancer cells. According to the authors, this so-called “parainflammation” may explain how a number of different forms of cancer begin.

 “Understanding the initial triggers of tumor formation is one of the main challenges in cancer research,” said Dvir Aran, PhD, a postdoctoral scholar in the Butte lab who was co-lead author of the new paper with Audrey Lasry, a PhD student in Ben-Neriah’s lab. “We think parainflammation could be a big part of this puzzle.”

 The research was published online on July 8 in the open-access journal Genome Biology.

 Common Cancer Gene Mutations ‘Turn Off the Brakes’

 Growing evidence over the past decade suggests that people who take a regular dose of aspirin or other non-steroidal anti-inflammatory drug (NSAID) are significantly less susceptible to colorectal cancer, breast cancer and a number of other malignancies. This relationship is mysterious, because most of the cancers that aspirin appears to prevent typically show no overt signs of inflammation.

 Aran and colleagues hypothesized that there must be some sort of low-level of inflammation, undetectable with standard methods, that could interact with gene mutations to trigger cancer.

 In a previous study, Ben-Neriah’s lab showed that they could induce just such a state of low-level tissue inflammation in mice, which they categorized as parainflammation. They found that non-immune cells, including cells known to give rise to cancer, were able to activate some of the same genetic pathways typically used by the immune system. These pathways then interacted with p53, a regulator of cellular division, to prevent the cells from continuing to grow and divide, driving them toward a state known as cellular senescence.

 But when p53 becomes mutated, as it does in many different forms of cancer, the researchers found that parainflammation loses its protective role and becomes dangerous for the tissue.

 “Without p53, the brakes are off, and the previously protective energy of parainflammation can drive the formation of tumors,” Ben-Neriah said.

 The new study identified a specific pattern of gene expression characteristic of carcinogenic parainflammation in mice with both experimentally induced intestinal parainflammation and mutated p53. This newly identified gene-expression signature, which gave the researchers a way to detect the previously invisible phenomenon, allowed them to detect parainflammation in an array of mouse organoid tumors, human cancer cell lines, and human tumor samples.

 The new work is an important advance in understanding the link between inflammation and cancer, said Yale School of Medicine immunobiologist Ruslan Medzhitov, PhD, who coined the term parainflammation in 2008 to describe a theoretical state of low-level inflammation, which he hypothesizes could play a beneficial role in helping cells respond to tissue stress or damage. “The ability to molecularly detect parainflammation should help devise cancer treatments that are tailored to these stereotypic paths the tumors follow,” he said.

 Linking Parainflammation to Human Cancer Mortality

 To determine the role of parainflammation in human cancers, the researchers mined The Cancer Genome Atlas (TCGA), a National Institutes of Health electronic database, and retroactively examined 6523 primary tumors of 18 different cancer types for the molecular signature of parainflammation. They found that more than a quarter of all tumor samples exhibited parainflammation, and that it was much greater in some cancer types than others: for example, more than three-quarters of pancreatic adenocarcinomas exhibited parainflammation, while no kidney cancers showed significant signs of parainflammation.

 The researchers found that tumor samples with the highest levels of p53 mutations also had the highest levels of parainflammation, corresponding with their hypothesis that parainflammation is permissive of p53-driven cancers. High parainflammation was particularly apparent in fast-growing cancers, such as pancreatic and bladder cancers. Within cancer types, higher rates of parainflammation were linked to increased mortality.

 In line with their initial hypothesis, the researchers also showed that NSAIDs dampened parainflammation in both cancerous mouse intestinal tumors and cancer cell lines of oral, pancreatic and colorectal origin. These results suggest that the newly developed genetic signature of parainflammation could also be used to better predict which patients would benefit from an aspirin regimen following cancer surgery.

 Though the results suggest aspirin may have great promise in fighting cancer, the researchers also cautioned that it is not without side effects. Aran envisions a genetic test for parainflammation, similar to existing tests for predicting breast cancer recurrence, to identify patients who would be most likely to benefit from a course of NSAIDs.

 Connecting the Dots of Public Genome Data

 Identification of the parainflammation signature is the result of a multi-year collaboration. The work began when Aran, whose background is in bioinformatics, was a PhD student in the lab of co-author Asaf Hellman, PhD, a researcher at Hebrew University Medical School. While Lasry led the animal and cell-line experiments from Ben-Neriah’s lab at Hebrew University, Aran joined Butte’s lab at UCSF to take advantage of the lab’s techniques for computationally analyzing public biomedical data sets.

 “The public genomic data allowed us to connect the dots and draw significance from mouse models to humans,” Aran said.

 Butte cited the new paper as a key example of what can be done when research data is shared broadly across the research community. “This paper shows how years of research data can be reused to study cancer immunology, one of the newest areas of cancer therapeutics,” he said. “More importantly, it shows the benefits of our efforts to connect research models of cancer, like cell lines and mouse models, with actual cancer therapy in humans, which remains a major challenge in cancer immunology, and one we have been specifically funded to address.”

 The research was supported by a Gruss Lipper Postdoctoral Fellowship; the National Cancer Institute of the National Institutes of Health; the Israel Science Foundation (ISF) Centers of Excellence, and the I-CORE program of ISF; the European Research Council; the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation (AMRF); and the Rosetrees Trust. The authors declare no competing financial interests. See the online version of the paper for a full list of authors.

 UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with nationally renowned programs in basic, biomedical, translational and population sciences; and a preeminent biomedical research enterprise. It also includes UCSF Health, which comprises two top-ranked hospitals, UCSF Medical Center and UCSF Benioff Children’s Hospital San Francisco, and other partner and affiliated hospitals and healthcare providers throughout the Bay Area.

 

Aspirin may not be that harmless but for many there are healthy ways

For years, the advice for preventing heart has been simple: take an aspirin every day; it can’t hurt. But new research suggests that patients taking the pills and doctors prescribing them may need to think twice about that advice.

The study, published today in the Journal of the American Medical Association, found that taking 300 milligrams or less of aspirin increases the risk of major stomach or brain bleeding by 55 percent, greater than previous research has suggested.

Italian researchers studied more than 370,000 hospitalized patients, looking for differences in how aspirin affects patients with diabetes and those without. But their findings apply to millions of people hoping to prevent heart problems with aspirin.

Of the more than 186,000 participants taking a daily dose of aspirin, researchers counted nearly 2,300 cases of gastrointestinal bleeding and nearly 1,300 cases of brain bleeding.

Dr. Antonio Nicolucci, one of the study’s authors, said the results show that the risks of bleeding are much higher than what doctors had previously suspected after several clinical trials and should prompt doctors to carefully consider a patient’s individual health before prescribing aspirin.

“If the risk of having a cardiovascular event is low, then the risk of bleeding will likely offset any beneficial effect of aspirin,” he said.

PHOTO: Taking daily aspirin may not be as harmless as doctors once thought.
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Taking daily aspirin may not be as harmless… View Full Size

PHOTO: Taking daily aspirin may not be as harmless as doctors once thought.

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Taking daily aspirin may not be as harmless as doctors once thought.
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But many say the study highlights the issue of calculating risks and benefits of any medical treatment, even one as seemingly harmless as taking an aspirin a day.”No preventive approach is without risk,” said Dr. Thomas Schwenk, Dean of the University of Nevada School of Medicine. “If the benefits are barely measurable but the risks are real and possibly greater, then the decision making may shift against the use of aspirin.”

For people with a history of heart attacks or stroke, doctors agree that taking aspirin is a key part of preventing a second problem. The American Heart Association, the American Diabetes Association and the U.S. Preventive Services Task Force all recommend a daily, low dose of aspirin for people who are at a 20 percent increased risk of heart problems. The benefits of preventing a second heart attack outweigh the risks of bleeding for most people.

In an editorial about the study, Dr. Jolanta Siller-Matula, of the Medical University of Vienna, put the numbers this way: for a group of 10,000 patients taking aspirin to prevent a second heart attack or stroke, data suggest the pill would prevent about 250 heart problems but would cause about 40 cases of brain bleeding.

“Thus the net benefit of aspirin for secondary prevention would substantially exceed the bleeding hazard,” she wrote.

But the issue gets murkier for those at a lower risk of heart disease, such as people who have some risk factors but have never had a heart attack. Siller-Matula wrote that for 10,000 of those patients, aspirin would be expected to prevent seven heart attacks or strokes, but cause problems in another four patients.

“When the cardiovascular risk is low, the adverse effects of aspirin overwhelm any benefit,” said Dr. Steve Nissen, chair of cardiovascular medicine at the Cleveland Clinic. “Unfortunately, many patients taking aspirin represent the ‘worried well’ rather than individuals with a high risk of coronary artery disease.”


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Notes: Most drugs are acidic to our body. Heart disease is related to kidney, lungs, liver and inflammation. New studies revealed that support and love is more potent than medicine, detox with 1 day fasting to clean our system and to maintain whole foods diet are key to living healthy. Oxygenation of our cells thru whole body exercise, fresh air, and even bariatic/oxygen therapy can help in our fight of getting rid of toxins in our body since heart disease is related to some toxic chemicals. Many of us forgot to drink alkaline water or consumed healthy salt free soup on a daily basis.