Fitness tracker, pain relief and home health monitor with HELO smart band

wearmonitor-all-health-vitals-and-more

HELO from Worldgn as wearable or fitness tracker with more health vitals monitoring has attachable germanium stones and Himalayan salts that can benefit your body in many ways.

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To get this fitness tracker for $320 and earn 10-20% referral fees in 197 countries, join here and order:

https://my.worldgn.com/join/careme

Email Connie at motherhealth@gmail.com for the compensation plan (a binary plan).

The use of these minerals has many proven effects on the body, and benefits people with common health problems: arthritis, pain, osteoporosis, low energy, high blood pressure, high cholesterol, heart disease, glaucoma, cataracts, depression, liver problems, food allergies, yeast infections, viral infections, heavy metal poisoning, and other conditions.

Germanium is an element which is commonly found in nature, a semiconductor indicated with Ge in the table of elements and atomic number 32. It is an antioxidant and its most important feature is that when it comes into contact with the skin, at a temperature of 32 °C, it favors negative ion rebalancing by activating the water molecules that are found in our bodies, enhancing circulation.

It reduces stress, rebalancing the ions. Also, penetrating deeply into the skin, muscles, tendons and ligaments, germanium improves blood circulation, eliminating the toxins, and it purifies the cells. Germanium facilitates the movement of oxygen and fresh nutrients, which can be effectively absorbed by the bloodstream.

Hematite improves iron absorption by the small intestine and it stimulates red blood cells production. This promotes better oxygenation of all body tissues and general health improvement.

The Himalayan Crystal salt stones help control water levels in the body and ensure more balanced pH levels in the body, at a cellular level, included in the brain. The Himalayan salt amplifies energy and an overall sense of well-being.

The minerals penetrate the skin to restore ionic balance, making us feel more energized, stress-free, active, alert, healthy, and in a good mood.  The antioxidant properties help the body keep maintain its balance and relaxes muscles and decrease pain.  The stones emit a high percentage of infrared rays that activate water molecules, improve blood circulation and the oxygen content in the blood, and leads to better quality of sleep.

The use at the dosage indicated on the packages and as supplied does not cause any undesired effect, except for a known hypersensitivity to the elements. In this case you can remove the plates and consult a doctor. The germanium does not lose its effectiveness over time. Hematite loses its magnetic effectiveness after 6 months. Himalayan Crystal Salt loses its effectiveness after 3 months.

Pain is Not Just a Matter of Nerves

Summary: Researchers reveal the role glial cells play in the sensation of pain.

Source: Medical University of Vienna.

The sensation of pain occurs when neural pathways conduct excitation generated by tissue damage to the spinal cord, where the nociceptive information is extensively pre-processed. From there, the information is transmitted to the human brain, where the sensation of “pain” is finally created. This is the general belief. However, researchers from the Division of Neurophysiology at MedUni Vienna’s Center for Brain Research have now discovered that pain is not just a matter of nerves but that non-neuronal cells, the glial cells, are also involved in clinically relevant pain models and their activation is sufficient to amplify pain. The study has now been published in the leading journal “Science”.

Glial cells are the commonest type of cells in the human brain and spinal cord. They surround neurons but are distinct from them and play an important supporting role – for example, in material transport and metabolism or the fluid balance in the brain and spinal cord.

Novel explanation for puzzling pain phenomena

At the same time, however, when they are activated – by pain processes, for example ­– glial cells are themselves able to release messenger substances, such as inflammatory cytokines. Glial cells therefore have two modes: a protective and a pro-inflammatory mode. “The activation of glial cells results in a pain-amplifying effect, as well as spreading the pain to previously unaffected parts of the body. For the very first time, our study provides a biological explanation for this and for other hitherto unexplained pain phenomena in medicine,” says Jürgen Sandkühler, Head of the Division of Neurophysiology at MedUni Vienna’s Center for Brain Research.

Image shows neurons.

Over-activation of glial cells in the spinal cord can, for example, be caused by strong pain stimuli from a wound or surgical intervention, or even by opiates. Sandkühler: “This could also explain why opiates are initially very good at relieving pain but then often cease to be effective. Another example is the phenomenon of “withdrawal” in drug addicts, where activated glial cells cause severe pain throughout the body.”

A healthy lifestyle can beneficially impact the glial cell system

According to Sandkühler, neuroinflammatory diseases of the brain, environmental factors and even the person’s own lifestyle can lead to activation of glial cells. Examples from the current literature are: depression, anxiety disorders and chronic stress, multiple sclerosis or Alzheimer’s and diabetes, as well as lack of exercise and poor diet. Sandkühler: “Glial cells are an important factor in ensuring the equilibrium of a person’s neuroinflammatory system.” The study results give grounds for speculation that improvements in a person’s lifestyle could have a beneficial impact upon this system and ensure that they generally suffer less pain or “minor niggles”, says Sandkühler: “It is therefore in our own hands: thirty minutes of moderate exercise three or four times a week, a healthy diet and avoiding putting on excess weight can make a huge difference.”

ABOUT THIS PAIN RESEARCH ARTICLE

Source: Medical University of Vienna
Image Source: This NeuroscienceNews.com image is adapted from the Medical University of Vienna press release.
Original Research: Abstract for “Gliogenic LTP Spreads Widely in Nociceptive Pathways” by M.T. Kronschläger, R. Drdla-Schutting, M. Gassner, S.D. Honsek, H.L. Teuchmann, and J. Sandkühler in Science. Published online November 10 2016 doi:10.1002/da.22577

CITE THIS NEUROSCIENCENEWS.COM ARTICLE
Medical University of Vienna. “Pain is Not Just a Matter of Nerves.” NeuroscienceNews. NeuroscienceNews, 11 November 2016.
<http://neurosciencenews.com/neurons-pain-amplification-5489/&gt;.

Abstract

Gliogenic LTP Spreads Widely in Nociceptive Pathways

Learning and memory formation involve long-term potentiation of synaptic strength (LTP). A fundamental feature of LTP induction in the brain is the need for coincident pre- and postsynaptic activity. This restricts LTP expression to activated synapses only (homosynaptic LTP) and leads to its input specificity. In the spinal cord, we discovered a fundamentally different form of LTP that is induced by glial cell activation and mediated by diffusible, extracellular messengers, including D-serine and tumor necrosis factor (TNF), and that travel long distances via the cerebrospinal fluid, thereby affecting susceptible synapses at remote sites. The properties of this gliogenic LTP resolve unexplained findings of memory traces in nociceptive pathways and may underlie forms of widespread pain hypersensitivity.

“Gliogenic LTP Spreads Widely in Nociceptive Pathways” by M.T. Kronschläger, R. Drdla-Schutting, M. Gassner, S.D. Honsek, H.L. Teuchmann, and J. Sandkühler in Science. Published online November 10 2016 doi:10.1002/da.22577

Long term use of certain pain relief medications linked with hearing loss among women

Asian News International

London [England], Dec. 15 (ANI): Women take note! Taking painkillers for headaches and back pains for twice a week can increase the risk of hearing loss, finds a study.

According to Mail Online, taking two painkillers — paracetamol or ibuprofen– a week for more than six years has been linked with significant hearing loss by nine percent, with the drugs thought to cut blood supply to the inner ear and expose it to noise damage.

The painkillers damage the tiny hairs within the ear, which help us hear, and have been linked in younger and older women with a higher risk of hearing loss.

Researchers examined 55,850 women between the age of 44 and 69 – almost half of whom reported a hearing problem.

The findings, published in the Journal of Epidemiology, backs similar research in men, suggesting middle-aged women, who commonly take paracetamol and ibuprofen for headaches and back pain, should consider cutting down.

“Hearing loss is extremely common and can have a profound impact on quality of life,” said senior study author Dr Gary Curhan from Women’s Hospital in the US.

“Finding modifiable risk factors could help us identify ways to lower risk before hearing loss begins and slow progression in those with hearing loss,” Curhan added.

Around one in six people in London have hearing problems, which can leave people feeling cut off and lonely and has been found to speed up memory loss and dementia.

The study suggests that Paracetamol is believed to deplete antioxidants within the ear, making the cochlea more vulnerable to noise-induced damage.

“Finding modifiable risk factors could help us identify ways to lower risk before hearing loss begins and slow progression in those with hearing loss,” Curhan added. (ANI)

Folate – Vit B9 deficiency or MTHFR gene mutation

mthfr-def

Folate – Vit B9 or MTHFR deficiency has a frequency of 1 in 1.9 .

Those with potentially “severe” mutations should check homocysteine with their doctor. Folate deficiency: A deficiency in folic acid (folate) could be linked to MTHFR mutation and is worth checking out. Common symptoms include extreme fatigue, light-headedness, and forgetfulness.

Homocysteine is an amino acid and breakdown product of protein metabolism that, when present in high concentrations, has been linked to an increased risk of heart attacks and strokes. Elevated homocysteine levels are thought to contribute to plaque formation by damaging arterial walls.

Homocysteine is an amino acid thought to damage the lining of your arteries and other cells of the body. It is naturally formed in the body, but gets broken down (recycled) by 5-MTHF.  Elevated homocysteine levels in the blood is an independent risk factor for heart disease, stroke and other forms of cardiovascular disease.  It has also been linked with a wide range of other health problems including macular degeneration, Alzheimer’s disease, hearing loss, depression and cancer.

MTHFR mutation/gene variation can impact how well your body metabolizes folate and folic acid. Both are forms of vitamin B9, required for numerous critical bodily functions.  A fault in this metabolic cycle is linked to many serious health problems (neck pain,others).

MTHFR, short for Methylenetetrahydrofolate Reductase, is a very important enzyme in the body.  It’s necessary for Methylation to occur, a metabolic process that switches genes on and off, repairs DNA and many other important things.  Methylation is also essential to convert both folate and folic acid – each a form of Vitamin B9 – into its active, usable form called 5-MTHF.

One reader, a Rehab, Nutrition and Lifestyle Coach, Josh Rubin from California notes:

“…Folic acid def[initely] leads to catabolism of histadine. Low levels of histadine creates catabolism in the body and has been shown to be as a marker to arthritic and RA conditions.

“Low folate levels can lead to inhibition of DNA synthesis, impaired cell division, and alterations in protein synthesis.”

Histidine can even help protect tissues from damage caused by radiation or heavy metals. High histidine foods include beef, lamb, cheese, chicken, turkey, soy, fish, nuts, seeds, eggs, beans, and whole grains. The recommended daily intake for histidine is 10mg per kilogram of body weight, or 4.5mg per pound.

Diet

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Diet should include greens, whole foods, lemon, Vit B and Vit C rich whole foods, potassium and iron-rich foods) and vinegar (to aid in absorbtion of nutrients). Vit C and vinegar help in the absorption of nutrients from whole foods.

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What is folic acid/vitamin B9?

Vitamin B9, more commonly known as folate or folic acid, is a water-soluble vitamin that is part of the B vitamin family. B vitamins/folate help support adrenal function, help calm and maintain a healthy nervous system, and are necessary for key metabolic processes. Folate occurs naturally in foods, while folic acid is the synthetic form of folate.

Why is vitamin B9 necessary?

Vitamin B9 is essential for human growth and development, encourages normal nerve and proper brain functioning, and may help reduce blood-levels of the amino acid homocysteine (elevated homocysteine levels have been implicated in increased risk of heart disease and stroke). Folic acid or folate may also help protect against cancers of the lung, colon, and cervix, and may help slow memory decline associated with aging.

Pregnant women have an increased need for folic acid: it supports the growth of the placenta and fetus, and helps to prevent several types of birth defects, especially those of the brain and spine. Pregnant women and women of child-bearing age should take extra caution to get enough folic acid (see below for recommended amounts).

What are the signs of a folic acid deficiency?

Deficiency has been linked to birth defects, low birth weight, pregnancy loss, depression, memory loss, and cervical dysplasia. Alcoholics, pregnant women, and people living in institutional settings are at a higher risk of vitamin B9 or folate deficiency.


Folate and Depression

Many studies, going back to the 1960s, show an elevated incidence of folate deficiency in patients with depression.2 Studies vary depending on the criteria used to define folate deficiency, but often, about one-third of depression patients were deficient. Given that depression is often accompanied by decreased appetite and weight loss, the high incidence of folate deficiency in depression patients is not surprising. However, there is some evidence, though not conclusive, that folate deficiency may be involved in the etiology of depression in a minority of patients. Alternatively, depressed mood may decrease appetite, lower folate levels and thereby help to prevent recovery from depression. A recent review and metaanalysis looked at the results from the limited number of studies that investigated the effect of giving folate to depression patients and concluded that “there is some evidence that augmentation of antidepressant treatment with folate may improve patient outcome.”3 Whether the putative beneficial effect of folate is limited to those with folate deficiency is not clear.1,3

If folate deficiency can contribute to depressed mood and folate supplementation is beneficial in patients, a plausible mechanism implicates serotonin. In most,4–8 but not all,9,10 studies on patients with neuropsychiatric disorders, folate deficiency was associated with low levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid (CSF). In one study, supplementation with folate restored CSF 5-HIAA levels to normal.8

There is also a decrease in serotonin synthesis in patients with 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency, a disorder of folate metabolism.11,12

While the mechanism relating folate deficiency to low serotonin is not known, it may involve S-adenosylmethionine (SAMe). SAMe is a major methyl donor formed from methionine. Folate is involved in a cycle that regenerates methionine from homocysteine after SAMe is demethylated to S-adenosylhomocysteine, with subsequent conversion to homocysteine. Folate deficiency decreases SAMe in the rat brain.13 In humans, SAMe is an antidepressant14,15 and increases CSF 5-HIAA levels.16 Thus, there is some consistency in what is known about the interrelations of folate, SAMe and depression.

Gene study pinpoints process that triggers painful bone disease

Researchers in Edinburgh and Dundee pinpoint a key gene in bone disease development: November 2015

Researchers at the Universities of Edinburgh and Dundee have pinpointed the mechanism by which a key gene contributes to the development of a painful bone disease.

The researchers, led by Dr Omar Albagha at the Centre for Genomic and Experimental Medicine, have found that a fault in the gene can trigger the bone defects that affect people with Paget’s disease, a condition that leads to bone pain, bone deformity and arthritis. The disease affects up to one million people in the UK.

The team is the first to identify that the gene – called OPTN – regulates the activity of specialised cells that keep bones healthy by breaking down old bone and replacing it. In Paget’s disease the number and activity of these bone-removing cells – called osteoclasts –are increased. This leads to the formation of abnormal bone and development of the disease.

In a study published in the journal Cell Reports, scientists identified the novel role played by OPTN in bone metabolism. The researchers have shown that OPTN regulates bone maintenance by slowing down the formation of bone-removing cells to keep the process of bone-removing and bone-building in balance.

The study identifies that genetic variations that increase the risk of disease do so by reducing the amount of OPTN produced by cells. This, in turn, leads to an increase in the number of bone-removing cells, prompting the normal repair process to go into overdrive and causing bones to become deformed and enlarged.

The researchers found that the gene is frequently less active in people with increased susceptibility to the disease. Further study found that mice with a defective version of the gene are more prone to the disease.

Researchers previously found that genetic variations in OPTN increase the risk of developing Paget’s disease, but its role in bone maintenance was unknown until now.

optn

Just Watching Hurts! Signs of Pain Seen in the Brain

Summary: Researchers report abnormal activation in areas that respond to normal pain when a person with CRPS witnesses another person experience painful stimuli.

Source: Aalto University.

Some people claim to experience pain just watching something painful to happen. This is true especially of people suffering from complex regional pain syndrome (CRPS), a disabling chronic pain disorder in a limb. In CPRS patients, both own movements and just observing other persons’ movements may aggravate the pain.

When you hurt yourself, pain receptors in the body send signals to different parts of the brain. As the result, you experience pain. Researchers in Aalto University, Finland, found that when CRPS patients feel pain caused by observing other person’s movements, their brains display abnormal activation in many such areas that respond to normal physical pain. Thus the pain that the CRPS patients felt during movement observation presented similarities to the “normal” pain associated with tissue damage.

“CPRS is a very complex disease with devastating chronic pain. Its pathophysiology is incompletely understood and definitive biomarkers are lacking. Our discovery may help to develop diagnostics and therapeutic strategies for CRPS patients,” said neurologist Jaakko Hotta, Doctoral Candidate at Aalto University.

In the study, the researchers analyzed functional magnetic resonance images from 13 upper-limb CRPS patients and 13 healthy control subjects who were viewing brief videos of hand actions, such as a hand squeezing a ball with maximum force.

brain scans are shown.

In the CPRS patients, watching hand actions was associated with abnormal brain activation patterns and a pattern-classification analysis differentiated the patients from the healthy subjects. These findings indicate that CRPS affects brain areas related to both pain processing and motor control.

ABOUT THIS PAIN RESEARCH ARTICLE

Source: Jaakko Hotta – Aalto University
Image Source: NeuroscienceNews.com image is credited to Jaakko Hotta/Aalto University.
Original Research: Abstract for “Abnormal brain responses to action observation in complex regional pain syndrome” by Jaakko Hotta, Jukka Saari, Miika Koskinen, Yevhen Hlushchuk, Nina Forss, Riitta Hari in Journal of Pain. Published online November 12 2016 doi:10.1016/j.jpain.2016.10.017

Aalto University “Just Watching Hurts! Signs of Pain Seen in the Brain.” NeuroscienceNews. NeuroscienceNews, 29 November 2016.
<http://neurosciencenews.com/pain-neurology-crps-5624/&gt;.

Abstract

Abnormal brain responses to action observation in complex regional pain syndrome

Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. Here, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper-limb CRPS patients (all females, ages 31–58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q < 0.05, false discovery rate corrected) included the hand representation area in the sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control.

Perspective

This article shows that in CRPS, the observation of others’ motor actions induces abnormal neural activity in brain areas essential for sensorimotor functions and pain. These results build the cerebral basis for action observation impairments in CRPS.

“Abnormal brain responses to action observation in complex regional pain syndrome” by Jaakko Hotta, Jukka Saari, Miika Koskinen, Yevhen Hlushchuk, Nina Forss, Riitta Hari in Journal of Pain. Published online November 12 2016 doi:10.1016/j.jpain.2016.10.017