MS and Sphingomyelin in blood for early detection

As a result of the autoimmune disease multiple sclerosis (MS), the myelin sheath of neuronal cells in the brain and spinal cord is degraded, resulting in loss of signal transduction capability. MS patients exhibit upregulation of certain cytokines in the cerebrospinal fluid, particularly tumor necrosis factor alpha. This activates sphingomyelinase, an enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide; sphingomyelinase activity has been observed in conjunction with cellular apoptosis.

Reduce stress to slow aging and Alzheimer’s – Dementia

TIA1 is a 3’UTR mRNA binding protein that can bind the 5’TOP sequence of 5’TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein.[1] Under stress conditions, TIA1 localizes to cellular RNA-protein conglomerations called stress granules.

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