Know your blood test results to help guide your wellness goals

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When my father had lung cancer in fourth-last stage, I saw that his PSA value is outside the range and other liver and kidney blood biomarkers. He had been coughing every night for the last 5-10 years , had tuberculosis many years before , been sleep deprived when he was working as a taxi driver, started smoking early but quit 15 years ago, eating charred BBQ and meat only diet and was working in a mining company for many years.

When my 82 yr old mom has groin pain, her platelet count is outside the normal range and so I target her immune system and gave her a combo of turmeric, ginger and oregano capsule from Whole Foods Store. I also massaged her with my mixture of massage oil and prepared whole foods meals to increase her immune system. I told her that when she has anxiety, her immune system will be weaker to fight any inflammation or infection. She always get an infection when she travels for 12000 miles and sitting for 13 hours inside the airplane.

In my upcoming ebook, Healing within – transform inside and out, a self help and self cure ebook will list top topics close to your heart , related to your habits and lifestyle, genetic predisposition and more. Email motherhealth@gmail.com to review the book as it is written.

The first step in preventive health is knowing your body, signs and symptoms, blood test results and other information you can get from your doctor and yourself.

Life Extension has a list of blood tests for men and women , email me if you want a test based on your personal health issues as I am one of their wholesellers.

Healing from within – transform inside and out part 1

Connie Dello Buono

 

Blood Test Results – Your Complete Guide to Understanding Numbers

https://www.newportnaturalhealth.com › … › Blood Sugar and Diabetes

Aug 20, 2012 – So if there are irregularities, other tests will be required. Useful for diagnosing anemia, this test determines how much of the total blood volume in the body consists of red blood cells. Redblood cells contain hemoglobin, which makes blood bright red. … Low levels of hemoglobin may indicate anemia.

The Ultimate Guide to Decoding Your Blood Test Results – Greatist

Feb 18, 2015 – Low platelet count (below 150,000 platelets per microliter, mcL) can indicate risk for excessive bleeding, while a high count (400,000 or above) may show a risk for blood clots. The meanplatelet value test measures the average amount of platelets and can reveal subtle disorders when platelet counts are normal.

Blood Test Results Explained | Health Testing Centers

Sample Test Results and Specific Blood Test Results ExplainedFollowing is a general example of theresults of a blood test, a cholesterol blood testResults, relevant ranges, and alerts are highlighted for illustrative purposes:

What to do when blood test results are not quite “normal” – Harvard …

Jun 3, 2016 – For example, if your routine blood work includes a test for calcium in the blood, your labmay list the normal range for calcium as 8.3 to 9.9 milligrams per deciliter (mg/dL).

Lab Test Results Guide: Positive vs Negative, Ranges, Accuracy, & More

https://www.webmd.com › A to Z Guides › Reference

Nov 25, 2017 – If you’re waiting for lab test results to come back or you’re trying to figure out what theymean, the process and all those medical terms and numbers can be … To check on how you’re doing generally, like cholesterol or blood sugar tests when you have a physical; To answer a specific question, like “Do you …

What Your Blood Test Results Mean – Women’s Health

Oct 15, 2012 – Those crazy-looking abbreviations and jumbles of numbers on your blood test resultsreveal a lot about your health—if you know how to assess them. Find out what your cholesterol, CBC, and glucose should read, and how to fix any trouble spots.

How To Read Your Wellness Blood Test Results – Walkin Lab

https://www.walkinlab.com › Home › Anemia

Jul 17, 2017 – The total protein test measures how much of the proteins albumin and globulin are in your body. Understanding your blood test results when it comes to protein… The normal range for total protein is between 6 and 8.3 (g/dL). High protein could mean inflammation or infections, such as viral hepatitis B or C, …

Lab Tests Online: Patient Resources

Reference Ranges and What They Mean. A reference range is a set of values that includes upper and lower limits of a lab test based on a group of otherwise healthy people. By comparing your test resultswith reference values, you and your healthcare provider can see if any of your test results fall outside the range of …

Understanding Your Lab Test Results – American Cancer Society

Apr 22, 2016 – When you have cancer it often seems like someone is always taking blood for some kind of testBlood tests are done to help watch your body’s response to treatment. They can show small changes before problems get serious. Keeping track of your results lets your doctor take action as soon as your blood …

Things Your Doctor Won’t Tell You About Your Blood Test Results …

https://www.everydayhealth.com › Healthy Living

Sep 6, 2017 – Routine blood tests are generally done to look for problems, so if your CBC, bloodchemistry, and cholesterol results fall within normal ranges, the doctor’s office may not reach out to you about your report. Or they may send you a copy with little or no explanation. But even if things appear normal, be sure to …

People also ask

Genetic Factors in Depression

Genetic factors involved in depression have been difficult to identify. In 2003 Science published an influential[1] study of Avshalom Caspi et al. who found that a gene-environment interaction (GxE) may explain why life stress is a predictor for depressive episodes in some individuals, but not in others, depending on an allelic variation of the serotonin-transporter-linked promoter region (5-HTTLPR).[2] Soon after, the results were replicated by Kenneth Kendler‘s group, raising hopes in the psychiatric genetics community.[3] By 2007 there were 11 replications, 3 partial replication and 3 non-replications of this proposed GxE. However, two of the largest studies[4][5]were negative.[6] Two 2009 meta-analyses were also negative; one included 14 studies,[7] and the other five, owing to different study selection criteria.[8]

A 2010 review found 17 replications, 8 partial replications (interaction only in females or only with one of several types of adversity), and 9 non-replications (no interaction or an interaction in the opposite direction). It also found that all studies using objective indicators or structured interviews to assess stress replicated the gene–environment interaction fully or partially, whereas all non-replications relied on self-reported measures of adversity. This review also argued that both 2009 meta-analyses were significantly biased toward negative studies.[9]

BDNF polymorphisms have also been hypothesized to have a genetic influence, but replication results have been mixed and, as of 2005, were insufficient for a meta-analysis.[10] Studies also indicate an association of decreased BDNF production with suicidal behavior.[11] However, findings from gene-environment interactions studies suggest that the current BDNF models of depression are too simplistic.[12]

A 2008 study found interactions (biological epistasis) in the signaling pathways of the BDNF and the serotonin transporter; the BDNF Val66Met allele, which was predicted to have reduced responsitivity to serotonin, was found to exercise protective effects in individuals with the short 5-HTTLPR allele that is otherwise believed to predispose individuals to depressive episodes after stressful events.[13] Thus, the BDNF-mediated signalling involved in neuroplastic responses to stress and antidepressants is influenced by other genetic and environmental modifiers.[12]

The largest genome-wide study to date failed to identify variants with genome-wide significance in over 9000 cases.[14]

Recently, a genetics study positively identified two variants with genome-wide association with major depressive disorder (MDD).[15] This study, conducted in Chinese Han women, identified two variants in intronic regions near SIRT1 and LHPP.[16]

Attempts to find a correlation between norepinephrine transporter polymorphisms and depression have yielded negative results.[17]

One review identified multiple frequently studied candidate genes. The 5-HTT SLC6A4 and 5-HTR2A gene’s yielded inconsistent results, however they may predict treatment results. Mixed results were found for BDNF Val66Met polymorphisms. Polymorphisms in tryptophan hydroxylase genes were found to be associated with suicidal behavior.[18]

A meta analysis of 182 case controlled genetic studies published in 2008 found Apolipoprotein verepsilon 2 to be protective, and found GNB3 825T, MTHFR 677T, SLC6A4 44bp insertion or deletions, and SLC6A3 40 bpVNTR 9/10 genotype conferred risk.[


MTHFR 677T

Methylene tetrahydrofolate reductase (MTHFR) is the rate-limiting enzyme in the methyl cycle, and it is encoded by the MTHFR gene.[3] Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Natural variation in this gene is common in healthy people. Although some variants have been reported to influence susceptibility to occlusive vascular disease, neural tube defects, Alzheimer’s disease and other forms of dementia, colon cancer, and acute leukemia, findings from small early studies have not been reproduced. Some mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.


 

GNB3 825T GENE

gnas.JPG


LHPP

LHPP (Phospholysine Phosphohistidine Inorganic Pyrophosphate Phosphatase) is a Protein Coding gene. Among its related pathways are Purine metabolism (REACTOME) and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include protein homodimerization activity and inorganic diphosphatase activity. An important paralog of this gene is HDHD2.

Caring for clients with anxiety disorders, the brain in the gut

enteric

Most geriatric and family practice doctors prescribe anti-anxiety and anti-depressent meds from Gabapentin to other narcotics with serious side effects as exhibit more Parkinson’s and Alzheimer’s disease.

One client of mine told her doctor that she does not need anti-depressant med and only need to sleep more or a low dose of a sleeping aid pill. She took melatonin from her own research, an anti-aging supplement.

Many seniors in care homes or living alone in bay area homes are set on their ways. They use the same recliner chair, bed, watch the same TV classic show, listen to the same music and so on. They do not want a lot of changes in their daily routines.

At times, when they could not sleep, they may have constipation and disturbed digestive system (see the section below on – The brain in the gut).

So when caring for seniors, ensure that changes are introduced slowly in their daily routines only when necessary and with their full cooperation and approval. Ensure that they are in a warm environment, cared for with proper meals and changed dry clothes, fed warm food, and just observing their daily needs and assist them with care and love.

Most of my caregivers at Motherhealth caregivers do bring love and care to be effective in their caregiving. They take these seniors as if they are part of their family.

The Enteric Nervous System – The Brain in the Gut

The gut has a mind of its own, the “enteric nervous system”. Just like the larger brain in the head, researchers say, this system sends and receives impulses, records experiences and respond to emotions. Its nerve cells are bathed and influenced by the same neurotransmitters. The gut can upset the brain just as the brain can upset the gut.

The gut’s brain or the “enteric nervous system” is located in the sheaths of tissue lining the esophagus, stomach, small intestine and colon. Considered a single entity, it is a network of neurons, neurotransmitters and proteins that zap messages between neurons, support cells like those found in the brain proper and a complex circuitry that enables it to act independently, learn, remember and, as the saying goes, produce gut feelings.

The gut’s brain is reported to play a major role in human happiness and misery. Many gastrointestinal disorders like colitis and irritable bowel syndrome originate from problems within the gut’s brain. Also, it is now known that most ulcers are caused by a bacterium not by hidden anger at one’s mother.

Details of how the enteric nervous system mirrors the central nervous system have been emerging in recent years, according to Dr. Michael Gershon, professor of anatomy and cell biology at Columbia-Presbyterian Medical Center in New York. He is one of the founders of a new field of medicine called “neurogastroenterology.”

The gut contains 100 million neurons – more than the spinal cord. Major neurotransmitters like serotonin, dopamine, glutamate, norephinephrine and nitric oxide are in the gut. Also two dozen small brain proteins, called neuropeptides are there along with the major cells of the immune system. Enkephalins (a member of the endorphins family) are also in the gut. The gut also is a rich source of benzodiazepines – the family of psychoactive chemicals that includes such ever popular drugs as valium and xanax.

In evolutionary terms, it makes sense that the body has two brains, said Dr. David Wingate, a professor of gastrointestinal science at the University of London and a consultant at Royal London Hospital. “The first nervous systems were in tubular animals that stuck to rocks and waited for food to pass by,” according to Dr. Wingate. The limbic system is often referred to as the “reptile brain.” “As life evolved, animals needed a more complex brain for finding food and sex and so developed a central nervous system. But the gut’s nervous system was too important to put inside the newborn head with long connections going down to the body,” says Wingate. Offspring need to eat and digest food at birth. Therefore, nature seems to have preserved the enteric nervous system as an independent circuit inside higher animals. It is only loosely connected to the central nervous system and can mostly function alone, without instructions from topside.

This is indeed the picture seen by developmental biologists. A clump of tissue called the neural crest forms early in embryo genesis. One section turns into the central nervous system. Another piece migrates to become the enteric nervous system. According to Dr. Gershon, it is only later that the two systems are connected via a cable called the vagus nerve.

The brain sends signals to the gut by talking to a small number of “command neurons,” which in turn send signals to gut interneurons that carry messages up and down the pike. Both command neurons and interneurons are spread throughout two layers of gut tissue called the “myenteric plexus and the submuscosal plexus.” Command neurons control the pattern of activity in the gut. The vagus nerve only alters the volume by changing its rates of firing.

The plexuses also contain glial cells that nourish neurons, mast cells involved in immune responses, and a “blood brain barrier” that keeps harmful substances away from important neurons. They have sensors for sugar, protein, acidity and other chemical factors that might monitor the progress of digestions, determining how the gut mixes and propels its contents.

As light is shed on the circuitry between the two brains, researchers are beginning to understand why people act and feel the way they do. When the central brain encounters a frightening situation, it releases stress hormones that prepare the body to fight or flee. The stomach contains many sensory nerves that are stimulated by this chemical surge – hence the “butterflies.” On the battlefield, the higher brain tells the gut brain to shut down. A frightened running animal does not stop to defecate, according to Dr. Gershon.

Fear also causes the vagus nerve to “turn up the volume” on serotonin circuits in the gut. Thus over stimulated, the gut goes into higher gear and diarrhea results. Similarly, people sometimes “choke” with emotion. When nerves in the esophagus are highly stimulated, people have trouble swallowing.

Even the so-called “Maalox moment” of advertising can be explained by the interaction of the two brains, according to Dr. Jackie D. Wood, chairman of the department of physiology at Ohio State University in Columbus, Ohio. Stress signals from the head’s brain can alter nerve function between the stomach and esophagus, resulting in heartburn.

In cases of extreme stress, Dr. Wood say that the higher brain seems to protect the gut by sending signals to immunological mast cells in the plexus. The mast cells secrete histamine, prostaglandin and other agents that help produce inflammation. This is protective. By inflaming the gut, the brain is priming the gut for surveillance. If the barrier breaks then the gut is ready to do repairs. Unfortunately, the chemicals that get released also cause diarrhea and cramping.

There also is an interaction between the gut brain and drugs. According to Dr. Gershon, “when you make a drug to have psychic effects on the brain, it’s very likely to have an effect on the gut that you didn’t think about.” He also believes that some drugs developed for the brain could have uses in the gut. For example, the gut is loaded with the neurotransmitter serotonin. According to Gershon, when pressure receptors in the gut’s lining are stimulated, serotonin is released and starts the reflexive motion of peristalsis. A quarter of the people taking Prozac or similar antidepressants have gastrointestinal problems like nausea, diarrhea and constipation. These drugs act on serotonin, preventing its uptake by target cells so that it remains more abundant in the central nervous system.

Gershon also is conducting a study of the side effects of Prozac on the gut. Prozac in small doses can treat chronic constipation. Prozac in larger doses can cause constipation – where the colon actually freezes up. Moreover, because Prozac stimulates sensory nerves, it also can cause nausea.

Some antibiotics like erythromycin act on gut receptors to produce ascillations. People experience cramps and nausea. Drugs like morphine and heroin attach to the gut’s opiate receptors, producing constipation. Both brains can be addicted to opiates.

Victims of Alzheimer’s and Parkinson’s diseases suffer from constipation. The nerves in their gut are as sick as the nerve cells in their brains. Just as the central brain affects the gut, the gut’s brain can talk back to the head. Most of the gut sensations that enter conscious awareness are negative things like pain and bloatedness.

The question has been raised: Why does the human gut contain receptors for benzodiazepine, a drug that relieves anxiety? This suggests that the body produces its own internal source of the drug. According to Dr. Anthony Basile, a neurochemist in the Neuroscience Laboratory at the National Institutes of Health in Bethesda, MD, an Italian scientist made a startling discovery. Patients with liver failure fall into a deep coma. The coma can be reversed, in minutes, by giving the patient a drug that blocks benzodiazepine. When the liver fails, substances usually broken down by the liver get to the brain. Some are bad, like ammonia and mercaptan, which are “smelly compounds that skunks spray on you,” says Dr. Basile. But a series of compounds are also identical to benzodiazepine. “We don’t know if they come from the gut itself, from bacteria in the gut or from food, but when the liver fails, the gut’s benzodiazepine goes straight to the brain, knocking the patient unconscious, says Dr. Basile.

The payoff for exploring gut and head brain interactions is enormous, according to Dr. Wood. Many people are allergic to certain foods like shellfish. This is because mast cells in the gut mysteriously become sensitized to antigens in the food. The next time the antigen shows up in the gut, the mast cells call up a program, releasing chemical modulators that try to eliminate the threat. The allergic person gets diarrhea and cramps.

Many autoimmune diseases like Krohn’s disease and ulcerative colitis may involve the gut’s brain, according to Dr. Wood. The consequences can be horrible, as in “Chagas disease,” which is caused by a parasite found in South America. Those infected develop an autoimmune response to neurons in their gut. Their immune systems slowly destroy their own gut neurons. When enough neurons die, the intestines literally explode.

A big question remains. Can the gut’s brain learn? Does it “think” for itself? Dr. Gershon tells a story about an old Army sergeant, a male nurse in charge of a group of paraplegics. With their lower spinal cords destroyed, the patients would get impacted. “At 10am every morning, the patients got enemas. Then the sergeant was rotated off the ward. His replacement decided to give enemas only after compactions occurred. But at 10 the next morning everyone on the ward had a bowel movement at the same time, without enemas.” Had the sergeant trained those colons?

The human gut has long been seen as a repository of good and bad feelings. Perhaps emotional states from the head’s brain are mirrored in the gut’s brain, where they are felt by those who pay attention to them.
Reference: Taken from “A contemporary view of selected subjects from the pages of The New York Times, January 23, 1996. Printed in Themes of the Times: General Psychology, Fall 1996. Distributed Exclusively by Prentice-Hall Publishing Company.

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Motherhealth Inc Caregivers for bay area homebound seniors 408-854-1883 motherhealth@gmail.com

http://www.clubalthea.com

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General Comments:

Since older adults are set on their ways, it is also difficult to change their perspectives and political views. For Bernie Sanders to win, all those 18 to 35 yrs old must vote with full research of political issues and truthful news.

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