Alzheimer’s and Dementia – the latest research

Alzheimer’s and Dementia

The latest research on degenerative cognitive disorders.

Old man's hand

7% – 26% of retired Americans over 65 have Dementia or cognitive impairment

Assessment of cognition using surveys and neuropsychological assessment: the Health and Retirement Study and the Aging, Demographics, and Memory Study.

OBJECTIVES:

This study examines the similarity of cognitive assessments using 1 interview in a large population study, the Health and Retirement Study (HRS), and a subsample in which a detailed neuropsychiatric assessment has been performed (Aging, Demographics, and Memory Study [ADAMS]).

METHODS:

Respondents are diagnosed in ADAMS as demented, cognitively impaired without dementia (CIND), or as having normal cognitive function. Multinomial logistic analysis is used to predict diagnosis using a variety of cognitive and noncognitive measures from the HRS and additional measures and information from ADAMS.

RESULTS:

The cognitive tests in HRS predict the ADAMS diagnosis in 74% of the sample able to complete the HRS survey on their own. Proxy respondents answer for a large proportion of HRS respondents who are diagnosed as demented in ADAMS. Classification of proxy respondents with some cognitive impairment can be predicted in 86% of the sample. Adding a small number of additional tests from ADAMS can increase each of these percentages to 84% and 93%, respectively.

DISCUSSION:

Cognitive assessment appropriate for diagnosis of dementia and CIND in large population surveys could be improved with more targeted information from informants and additional cognitive tests targeting other areas of brain function.

https://www.ncbi.nlm.nih.gov/pubmed/21743047

Cognitive impairment among Mexican-Americans age 65 and older

cog mex.JPG

https://academic.oup.com/gerontologist/article/doi/10.1093/geront/gnx090/3859887/Age-of-Migration-Differentials-in-Life-Expectancy

Do most people get Alzheimer’s disease and if so should they not learn anything new?

Connie b. Dellobuono
Connie b. Dellobuono, Alzheimer’s and Parkinson’s disease health blogger at http://www.clubalthea.com

Diet Soda Associated With Stroke, Dementia

But can’t determine causality; some associations diminished with adjustments

Higher consumption of artificially sweetened soft drinks was associated with an increased risk of both stroke and dementia in an analysis of more than 4,000 participants in the Framingham Heart Study Offspring cohort, researchers found.

In the observational study, those who drank at least one artificially-sweetened beverage a day were nearly three times more likely to develop ischemic stroke (HR 2.96, 95% CI 1.26–6.97) and 2.9 times more likely to develop Alzheimer’s disease (95% CI 1.18–7.07) over 10 years than those who abstained, Matthew Pase, PhD, of Boston University School of Medicine, and colleagues reported in the American Heart Association’s journal Stroke.

However, sugary beverages weren’t tied to an increased risk of stroke or dementia — a finding the authors called “intriguing,” and one that could have been due to survival bias.

“It is possible that individuals with high intakes of sugary beverages may have died earlier from other illnesses such as heart disease,” Pase told MedPage Today. “It is also worth noting that our sample consumed diet soda more frequently than sugar-sweetened soda and this may contribute to differences in findings between regular and diet soda.”

He cautioned that the association between artificially sweetened drinks and stroke and dementia seen in their study does not imply causation — a point emphasized by Marion Nestle, PhD, professor of nutrition, food studies, and public health at New York University, who wasn’t involved in the study.

“Association is not the same as causation, although the survival curves are impressive,” Nestle said. “I wish the authors had offered a plausible hypothesis for how artificial sweeteners could be causally related to stroke and dementia.”

Several other experts commented on the “controversial but inconclusive” nature of the association.

“The relationship with artificially sweetened beverages was not simple or straightforward,” said Keith Fargo, PhD, of the Alzheimer’s Association. “When the researchers controlled for other risk factors, particularly cardiovascular risk factors, it explained most of the association between artificially sweetened beverage intake and the development of dementia. This kind of data does not allow us to say that drinking [these] beverages causes dementia, or that cutting down on artificially sweetened beverages will reduce a person’s risk for dementia.”

Pase and colleagues analyzed data from the Framingham Heart Study Offspring cohort on people over age 45 years for the stroke arm (N=2,888) and people over age 60 years for the dementia arm (N=1,484). Both groups were primarily Caucasian and were just under 50% male.

Beverage intake was quantified using the Harvard semiquantitative food-frequency questionnaire at three points: cohort examinations five (1991–1995), six (1995–1998), and seven (1998–2001). Participants were then followed for more than 10 years to determine development of stroke or dementia.

Notably, data collection did not distinguish between the types of artificial sweeteners used in the beverages.

Pase and colleagues found that higher recent and cumulative intake of artificially sweetened soft drinks was linked to an increased risk of ischemic stroke, all-cause dementia, and Alzheimer’s dementia — even after adjustment for total caloric intake, diet quality, physical activity, and smoking status.

However, the associations between recent and higher cumulative intake of artificially sweetened soft drinks and dementia were no longer significant after additional adjustment for vascular risk factors and diabetes mellitus.

“Because our study was observational, we are unable to determine whether artificially sweetened soft drink intake increased the risk of incident dementia through diabetes mellitus or whether people with diabetes mellitus were simply more likely to consume diet beverages,” Pase said.

Pase noted the findings complement their sister study, published in Alzheimer’s & Dementia, that found higher consumption of both sugary and diet beverages was associated with smaller brain volumes, a marker of accelerated brain aging.

Also using data from the Framingham Heart Study Offspring cohort, this study found that people who more frequently consumed sugary beverages, including sodas and fruit juices, were more likely to have poorer memory, smaller overall brain volumes, and smaller hippocampal volumes.

The researchers concluded that their studies highlight a need for more research into this area, especially given how often people drink artificially-sweetened beverages.

In an accompanying editorial in Stroke, Ralph Sacco, MD, of the University of Miami Miller School of Medicine, agreed, writing that the findings “encourage further discussion and more research into this question, for even small causal effects would have tremendous effects on public health due to the popularity of both artificially sweetened soft drinks and sugar sweetened soft drinks consumption. Both sugar-sweetened and artificially sweetened soft drinks may be hard on the brain.”

“This kind of research is critical for examining and uncovering public health relationships that may eventually lead to actionable recommendations,” added Fargo.

Rachel Johnson, PhD, MPH, RD, past chair of the American Heart Association’s Nutrition Committee and professor at the University of Vermont, suggested that people stick to water, low-fat milk, or other beverages without added sweeteners until more data are available: “We know that limiting added sugars is an important strategy to support good nutrition and healthy body weights, and until we know more, people should use artificially sweetened drinks cautiously,” she said in a statement.

The researchers acknowledged several study limitations, including the observational nature of the data, the absence of ethnic minorities, and the use of a self-reported questionnaire to obtain dietary intake data, which may be subject to recall bias.

“Even if someone is three times as likely to develop stroke or dementia,” Pase said, “it is by no means a certain fate.”

Pase reported funding from the National Health and Medical Research Council.

The Framingham Heart Study is supported by the National Heart, Lung, and Blood Institute and by grants from the National Institute on Aging and the National Institute of Neurological Disorders and Stroke.

Sacco received a National Institutes of Health grant for the Northern Manhattan Study. Gardener is also funded by the National Institutes of Health for her work on the Northern Manhattan Study.

Reviewed by F. Perry Wilson, MD, MSCE Assistant Professor, Section of Nephrology, Yale School of Medicine and Dorothy Caputo, MA, BSN, RN, Nurse Planner

Primary Source: Pase M, et al “Sugar and artificially sweetened beverages and the risks of incident stroke and dementia a prospective cohort study” Stroke 2017; DOI: 10.1161/STROKEAHA.116.016027.

Secondary Source: Wersching H, et al “Sugar-sweetened and artificially sweetened beverages in relation to stroke and dementia are soft drinks hard on the brain?” Stroke 2017; DOI: 10.1161/STROKEAHA.117.017198.

Music as Medicine: Using Music to Help Dementia and Alzheimer’s Patients

Summary: Music could have unexpected benefits for those with Alzheimer’s disease.

Source: Ithaca College.

Music and voice major Jessica Voutsinas ’18 was singing the classic song “Over the Rainbow” to a resident at Longview — an adult residential facility near the Ithaca College campus — when the woman unexpectedly lit up and began telling stories about her life and children in a breakthrough of memory recall.

Voutsinas started visiting Longview as part of a new course at Ithaca College called Exploring Music as Medicine, which teaches students how to perform for dementia and Alzheimer’s patients and then assigns them to local nursing homes to bring music to residents. Since the launch of the program, dozens of patients in Tompkins County have experienced its benefits.

“You play familiar music,” lecturer and course cofounder Jayne Demakos ’78 says. “That’s really what people with Alzheimer’s and dementia will respond to.”

“The class was a transformative experience for me,” says Voutsinas. “It seemed unbelievable that music could do something that pills can’t. But after witnessing this and experiencing it for myself, my whole perception of music changed.”

Ryan Mewhorter ’19, a voice and performance major, was introduced to the idea of the healing power of music when he heard School of Music Dean Karl Paulnack speak about the program at the beginning of his first year at IC.

Having lost his grandfather to Alzheimer’s disease, Mewhorter immediately wanted to become involved in the project. By his second semester on campus, he had founded a student organization called Healing through Musical Companionship. The club now has 50 members who visit Beechtree Center for Rehabilitation and Nursing in downtown Ithaca each week to play recorded music for patients. Using recorded music allows students who are not musicians to help trigger residents’ memories and encourage positive emotional responses.

During her first visit to Beechtree in February 2016, club member Kathryn Kandra ’19 met a woman who was slumped in her wheelchair, head tucked down toward her lap. Kandra began playing the show Annie on an iPod, and within minutes the woman started singing along and conducting the music. Halfway through act one, she began asking Kandra about her life at Ithaca College.

“When I met her, she was completely nonverbal,” Kandra says. “It was amazing that I could give her at least 10 minutes of this lucidness and companionship.”

Mewhorter also loves bringing that feeling to Alzheimer’s and dementia patients, although he found that the live music program through the music course allowed him to make a more direct connection with residents.

Image shows a volunteer playing music for an alzheimer's patient.

“Live music has this feeling that is more personal,” he says. “When you put headphones on a resident, there isn’t a whole lot of room to communicate. When you perform music for them, they can sing along and make eye contact with you and follow the beat.”

Seeing the incredible enthusiasm for both the Exploring Music as Medicine course and Healing through Musical Companionship club has sparked talk of expanding the programs. Paulnack says it is possible that the School of Music may consider creating a major or minor in music as medicine that would emphasize both a high level of musicianship and the healing power of music. The program would involve the departments of music, recreation and leisure studies, gerontology, speech-language pathology and audiology, occupational therapy, and writing.

“We don’t claim to know what we’re doing yet,” says Paulnack. “We just want to jump in with both feet and explore it.”

ABOUT THIS MUSIC AND ALZHEIMER’S DISEASE RESEARCH ARTICLE

Source: Dan Verderosa – Ithaca College
Image Source: NeuroscienceNews.com image is credited to Robyn Wishna/Ithaca College.
Original Research: We will report on the findings of this research once the study is complete.