Alcohol causes gut damage with bacteria entering the blood stream

Eat whole foods or nuts rich in magnesium, potassium and calcium before drinking alcohol late afternoon.  Always have protein when drinking. Alcohol facilitates aging.

Connie

How Alcohol Ruins Your Health

By Dr Mercola

Acutely, alcohol depresses your central nervous system, which slows down the communication between your brain cells. Your limbic system, which controls emotions, is also affected. This is why alcohol consumption lowers your inhibitions.

Your prefrontal cortex, a brain region associated with reasoning and judgment, also slows in response to alcohol, leading to more impulsive behavior and poor judgment.

At higher doses, your cerebellum, which plays a role in muscle activity, will also be impacted, leading to dizziness and loss of balance. Over time — even over as short a period as one month — alcohol:4,5,6

Increases liver stiffness, which increases your risk of liver cirrhosis. In the film, after one month, the liver stiffness of the binge-drinking brother was increased from 3.9 to 4.9 — a 25 percent increase in liver inflammation that leads to cirrhosis.

The moderate-drinking brother fared nearly as badly. His liver stiffness increased from 3.9 to 4.8, so spreading the drinks out did not make any significant difference in terms of the liver damage caused by 21 units of alcohol per week.

Diminishes the formation of memories due to ethanol buildup in the brain. This is why you may not remember what you did while you were drunk. Alcohol also causes your hippocampus to shrink, which affects memory and learning.

Promotes systemic inflammation. The two brothers both had significant increases in five different inflammatory markers, although binge drinking caused a more dramatic rise.

Studies have shown even a single binge causes a dramatic rise in inflammation. In other words, your body reacts to alcohol in the same way as it reacts to injury or infection.

Increases stress on your heart, raising your risk for cardiomyopathy, arrhythmias, high blood pressure and stroke.

Blood alcohol levels spike two to three hours AFTER your last drink, which means it may occur in the middle of the night during sleep. This raises your risk of accidental death due to choking on your own vomit and/or suffering cardiac failure or stroke while sleeping.

Significantly increases endotoxin levels. In other words, alcohol causes gut damage allowing bacteria to escape from your gut into your blood stream.

The film showed that bingeing caused significantly worse damage, suggesting one week between binges is nowhere near enough to heal the gut damage caused by high amounts of alcohol. That said, regular consumption also led to elevated endotoxin levels, suggesting 21 units of alcohol per week is too much, and “sensible” drinking limits likely need to be much lower. How low is still unclear.

These are just a handful of the physical effects of alcohol. In reality, alcohol affects every part of your body, as shown in this Healthline infographic.7 In terms of chronic disease, studies have linked excessive alcohol consumption with an increased risk for poor immune function (which raises your risk for most diseases), pancreatitis and cancer.

Eating Fish May Reduce Multiple Sclerosis Risk

Eating Fish May Reduce Multiple Sclerosis Risk

Summary: A new study reveals eating fish regularly and taking daily fish oil supplements may reduce the risk of developing multiple sclerosis. Researchers report high fish intake is associated with a 45% reduced risk of developing MS.

Source: AAN.

Eating fish at least once a week or eating fish one to three times per month in addition to taking daily fish oil supplements may be associated with a reduced risk of multiple sclerosis (MS), according to a preliminary study released today that will be presented at the American Academy of Neurology’s 70th Annual Meeting in Los Angeles, April 21 to 27, 2018. These findings suggest that the omega-3 fatty acids found in fish may be associated with lowering the risk of developing MS.

Multiple sclerosis is a disease of the central nervous system that affects communication between the brain and other parts of the body. With MS, the body’s immune system attacks myelin, the fatty white substance that insulates and protects the nerves. This disrupts the signals between the brain and the rest of the body. Symptoms of MS may include fatigue, numbness, tingling or difficulty walking. The first episode of MS symptoms, lasting at least 24 hours, is known as clinically isolated syndrome. There is no cure for MS.

“Consuming fish that contain omega-3 fatty acids has been shown to have a variety of health benefits, so we wanted to see if this simple lifestyle modification, regularly eating fish and taking fish oil supplements, could reduce the risk of MS,” said study author Annette Langer-Gould, MD, PhD, of Kaiser Permanente Southern California in Pasadena, Calif., and a member of the American Academy of Neurology.

For this study, researchers examined the diets of 1,153 people with an average age of 36 from a variety of backgrounds, about half of whom had been diagnosed with MS or clinically isolated syndrome.

Participants were asked about how much fish they regularly ate. High fish intake was defined as either eating one serving of fish per week or eating one to three servings per month in addition to taking daily fish oil supplements. Low intake was defined as less than one serving of fish per month and no fish oil supplements. Examples of fish consumed by study participants include shrimp, salmon and tuna.

salmon

The study found that high fish intake was associated with a 45 percent reduced risk of MS or clinically isolated syndrome when compared with those who ate fish less than once a month and did not take fish oil supplements. A total of 180 of those with MS had high fish intake compared to 251 of the healthy controls.

The study also looked at 13 genetic variations in a human gene cluster that regulates fatty acid levels. Researchers found two of the 13 genetic variations examined were associated with a lower risk of MS, even after accounting for the higher fish intake. This may mean that some people may have a genetic advantage when it comes to regulating fatty acid levels.

While the study suggests that omega-3 fatty acids, and how they are processed by the body, may play an important role in reducing MS risk, Langer-Gould emphasizes that it simply shows an association and not cause and effect. More research is needed to confirm the findings and to examine how omega-3 fatty acids may affect inflammation, metabolism and nerve function.

Fish such as salmon, sardines, lake trout and albacore tuna are generally recommended as good sources of omega-3 fatty acids.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Funding: The study was supported by the National Institute of Neurological Disorders and Stroke.

Source: Renee Tessman – AAN
Publisher: Organized by NeuroscienceNews.com.

Less melanin in white people leads to less folate for blood production

Less melanin in white leads to less folate and more melanin in dark colored skin people affects Vitamin D and Calcium absorption

White people must get sunshine to help in folate absorption (folic acid – important nutrient for the blood ) while dark-colored skin people must eat whole foods rich in Vitamin D3 , calcium , omega 3 , Vitamin K2 and magnesium to protect them from diseases related to the heart and circulation/vascular system.

As a result, depression is prevalent among whites while circulatory health issues are common among dark colored skin.

See your doctor for more preventive measures.

Connie Dello Buono

The color of skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred into the keratinocytes via a cellular organelle called a melanosome (Figure 5.7).

This figure consists of two diagrams side by side. The right diagram shows development of light colored skin; the left shows development of dark-colored skin. In both, a brown melanocyte sits at the border between the dermis and epidermis. The melanocyte has a large nucleus and six finger-like extensions. These reach between cells of the stratum basalis. Sections of the extensions detach and travel through the skins. These are melanosomes. In the left diagram, both the melanocyte and melanosomes contain melanin particles, shown as dark dots. Melanosomes travel upwards to outer skin layers, releasing melanin. As a result, keratinocytes in the left diagram contain several melanin particles that darken skin color. In light colored skin, the melanocyte contains no melanin. It still releases melanosomes into upper layers of the skin; however, these melanosomes contain no melanin. Therefore, the skin does not darken and remains light.
Figure 5.7. Skin Pigmentation
The relative coloration of the skin depends of the amount of melanin produced by melanocytes in the stratum basale and taken up by keratinocytes.

Melanin occurs in two primary forms. Eumelanin exists as black and brown, whereas pheomelanin provides a red color. Dark-skinned individuals produce more melanin than those with pale skin. Exposure to the UV rays of the sun or a tanning salon causes melanin to be manufactured and built up in keratinocytes, as sun exposure stimulates keratinocytes to secrete chemicals that stimulate melanocytes.

The accumulation of melanin in keratinocytes results in the darkening of the skin, or a tan. This increased melanin accumulation protects the DNA of epidermal cells from UV ray damage and the breakdown of folic acid, a nutrient necessary for our health and well-being.

In contrast, too much melanin can interfere with the production of vitamin D, an important nutrient involved in calcium absorption.

Thus, the amount of melanin present in our skin is dependent on a balance between available sunlight and folic acid destruction, and protection from UV radiation and vitamin D production.

It requires about 10 days after initial sun exposure for melanin synthesis to peak, which is why pale-skinned individuals tend to suffer sunburns of the epidermis initially. Dark-skinned individuals can also get sunburns, but are more protected than are pale-skinned individuals. Melanosomes are temporary structures that are eventually destroyed by fusion with lysosomes; this fact, along with melanin-filled keratinocytes in the stratum corneum sloughing off, makes tanning impermanent.

Too much sun exposure can eventually lead to wrinkling due to the destruction of the cellular structure of the skin, and in severe cases, can cause sufficient DNA damage to result in skin cancer.

When there is an irregular accumulation of melanocytes in the skin, freckles appear. Moles are larger masses of melanocytes, and although most are benign, they should be monitored for changes that might indicate the presence of cancer (Figure 5.8).

Five photos of moles. The three upper photos show moles that are small, flat, and dark brown. The bottom left photo shows a dark black mole that is raised above the skin. The bottom right photo shows a large, raised, reddish mole with protruding hairs.
Figure 5.8. Moles
Moles range from benign accumulations of melanocytes to melanomas. These structures populate the landscape of our skin. (credit: the National Cancer Institute)
 
 

SKIN DISCOLORATION

The first thing a clinician sees is the skin, and so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs. Although neither is fatal, it would be hard to claim that they are benign, at least to the individuals so afflicted.

Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily due to the inability of melanocytes to produce melanin. Individuals with albinism tend to appear white or very pale due to the lack of melanin in their skin and hair. Recall that melanin helps protect the skin from the harmful effects of UV radiation. Individuals with albinism tend to need more protection from UV radiation, as they are more prone to sunburns and skin cancer. They also tend to be more sensitive to light and have vision problems due to the lack of pigmentation on the retinal wall. Treatment of this disorder usually involves addressing the symptoms, such as limiting UV light exposure to the skin and eyes.

In vitiligo, the melanocytes in certain areas lose their ability to produce melanin, possibly due to an autoimmune reaction. This leads to a loss of color in patches (Figure 5.9). Neither albinism nor vitiligo directly affects the lifespan of an individual.

This photo shows the back of a man’s neck. There is a large, discolored patch of skin at the base of his hairline. The discolored area extends over the ears onto the cheeks, toward the front of the face. The man’s head and facial hair are mostly gray, but white patches of hair are seen above the discolored skin.
Figure 5.9. Vitiligo
Individuals with vitiligo experience depigmentation that results in lighter colored patches of skin. The condition is especially noticeable on darker skin. (credit: Klaus D. Peter)
 

Other changes in the appearance of skin coloration can be indicative of diseases associated with other body systems. Liver disease or liver cancer can cause the accumulation of bile and the yellow pigment bilirubin, leading to the skin appearing yellow or jaundiced (jaune is the French word for “yellow”). Tumors of the pituitary gland can result in the secretion of large amounts of melanocyte-stimulating hormone (MSH), which results in a darkening of the skin. Similarly, Addison’s disease can stimulate the release of excess amounts of adrenocorticotropic hormone (ACTH), which can give the skin a deep bronze color.

A sudden drop in oxygenation can affect skin color, causing the skin to initially turn pale (white), a condition called pallor. With a prolonged reduction in oxygen levels, dark red deoxyhemoglobin becomes dominant in the blood, making the skin appear blue, a condition referred to as cyanosis (kyanos is the Greek word for “blue”).

This happens when the oxygen supply is restricted, as when someone is experiencing difficulty in breathing because of asthma or a heart attack. However, in these cases the effect on skin color has nothing do with the skin’s pigmentation.

INTERACTIVE LINK

This ABC video follows the story of a pair of fraternal African-American twins, one of whom is albino. Watch this video to learn about the challenges these children and their family face. Which ethnicities do you think are exempt from the possibility of albinism?

Calcium and magnesium balance 60:40 ratio

Mineral Nutrients Balance

Mineral Nutrients Balance

by Connie Dello Buono at http://www.clubalthea.com

Iron Balance (am)

Calcium and Phosphorous Balance (pm)

Toxic metals Mercury, Arsenic , Lead , etc

Molybdenum and Manganese aid iron metabolim and lowers Copper and magnesium

Balance of Sodium, Potassium, Magnesium and  Calcium

Calcium lowers manganese

Calcium antagonist with Lead

Iron is lowered by Calcium and magnesium

Magnesium lowers sodium , potassium and manganese

Potassium lowers calcium and magnesium and synergistic with sodium

Phosphorus synergestic with calcium and antagonist with Manganese

Boron and Vitamin D aids in calcium and magnesium metabolism

Sulphur and copper lowers Selenium and zinc Selenium antagonistic with Mercury and arsenic

Calcium and Molybdenum and Silica

Calcium and Silica lowers Aluminum and Lead

Mercury lowers Silica
Copper, manganese and iron are synergistic

Zinc is lowered by Copper, calcium and Iron

Zinc has relationship with Aldosterone, cortisol, testosterone and progesterone Extra Copper and Manganese lowered by Zinc
Iodine

Iodine has relationship with copper, selenium and magnesium

Lowered by mercury and cobalt

Omega 3, Vitamin D3 and Vitamin K2 aid in calcium and magnesium metabolism

Note: Vinegar and citrus help in the absorption of minerals in whole foods. Only 20% of iron are absorbed from plants and more than 35% are absorbed from animal based foods. Calcium and magnesium ratio is 60:40 . Nuts, beans and lentils and dark leafy greens , fish, seeds, shellfish , whole grains and mushrooms are tops in minerals

Calcium, magnesium, Vitamin D3 and K2 and Omega-3s cut risk of cancer

Eat eggs, fish, pickled veggies and wholefoods from cooked/raw veggies and fruits to promote cell growth. These foods are rich in Vitamin D3 and K2.
Vitamin D3 and K2 ensures calcium in bones and not in other cells.

Cancer risks are prevalent when consuming processed meat and chemicals/drugs/medications rich in un-absorbed free calcium (CA++).

Fish Oil. Calcium, magnesium (Ca:Mg in 60:40 ratio), Vitamin D3 and K2 from whole foods and Omega-3s cut risk of metabolic syndrome and cancer. These nutrients also help improve components of metabolic syndrome and reduce risk for cardiovascular disease.

calcium 2 pluscauses of cell damage

Bioactive Compounds and Cancer – Page 449 – Google Books Result

John A. Milner, ‎Donato F. Romagnolo – 2010 – ‎Medical

Experiments show that unabsorbed calcium in the lumen of the colon can prevent the adverse effects of bile acids and free fatty acids on the epithelial cells. … The bile and fatty acids have been shown to have irritating effects and to stimulate cell proliferation, thereby promoting a variety of cell damagingeffects in the colon.

Overview of Calcium – Dietary Reference Intakes for Calcium and …

by AC Ross – ‎2011 – ‎Cited by 1 – ‎Related articles

Calcium is excreted through the feces as unabsorbed intestinal calcium and is shed in mucosal cellsand secretions including saliva, gastric juices, pancreatic juice, and bile. Endogenous fecal calciumlosses are approximately 2.1 mg/kg per day in adults and about 1.4 mg/kg per day in children (Abrams et al., 1991).

Handbook of Dairy Foods and Nutrition, Second Edition

Parathyroid hormone and 1,25-dihydroxy vitamin D are thought to increase blood pressure through increases in intracellular free calcium and in muscle tone.” These observations serve to … This increases the likelihood that the cells lining the colon will be damaged, proliferate, and progress toward cancer. Epidemiologic …

API Textbook of Medicine (Volume I & II)

YP Munjal – 2015 – ‎Medical

Iron, folic acid and calcium are preferentially absorbed in the duodenum and proximal jejunum, which are also the sites maximally affected in … due to eosinophil infiltration Mucosal damage due to bacteria-laden macrophages Epithelial cell infection with or without mucosal invasion leading to damage to villuscells, often …

Plant Physiological Ecology: Field methods and instrumentation

R. Pearcey, ‎H.A. Mooney, ‎P.W. Rundel – 2012 – ‎Science

This equilibration period also serves to rinse any unabsorbed ions out of the free space between rootcells. Next, roots are transferred for a short time (e.g. 10–20 min) to a radioactively labeled solution (containing calcium) of the nutrient being studied, then rinsed in a … First, does removing roots from soil damage them?

Calcification and Its Treatment with Magnesium and Sodium Thiosulfate

drsircus.com/…/calcification-and-its-treatment-with-magnesium-and-sodium-thiosulfat…

Dec 8, 2009 – Magnesium acts as an antioxidant against free radical damage of the mitochondria. Magnesium has been called nature’s “calcium channel blocker” because of its ability to prevent coronary artery spasm, arrhythmias, and to reduce blood pressure. “Calcium enters the cells of the heart by way of calcium …

Calcium1 | Basicmedical Key

Jul 27, 2016 – For that reason, cells must keep free calcium ion concentrations in the cytosol at extremely low levels, typically on the order of 100 nmol. This is 10,000-fold lower than the … of proteins to bind calcium. Calcification in tissues other than bones and teeth is generally a sign of tissue damageand cell death.

Chapter 11. Calcium

In the cellular compartment the total calcium concentration is comparable with that in the ECF, but thefree calcium concentration is lower by several orders of …. The unabsorbed component appears in the faeces together with the unabsorbed component of digestive juice calcium known as endogenous faecal calcium. Thus …

Calcium – WORLD HEALTH MALL

Whenever an electron is torn from an atom a little spark is produced that can damage cell membranes. It’s called free radical damage and can be seen under a microscope in live blood cell analysis. … Significant amount of unabsorbed calcium left in the body will interact with other inorganic compounds to form stones.

The Vitamin Combination That May Reduce Your Osteoporosis

May 16, 2012 – When you’re supplementing with calcium and vitamin D3, you must also take vitamin K2 to reduce your osteoporosis risk.

The Delicate Dance Between Vitamins D and K – Dr. Mercola

Mar 26, 2011 – According to recent findings, the benefits of vitamin D, in terms of bone strength and cardiovascular health, are greatly enhanced when combined with vitamin K. Vitamin D improves your bone health by helping you absorb calcium. However, it is vitamin K that directs calcium to your skeleton, to prevent it …

Vitamin D supplements: Are yours helping or hurting you?

Almost every expert recommends it. And everyone’s taking it. But what if we’ve been using it wrong? What if our vitamin D supplements aren’t really helping us at all? If your car’s oil light went on once a week…and every time you checked the oil, it was running low…what would you do? Shrug? Top up the oil tank (again)? …

Vitamins K1 and K2: The Emerging Group of Vitamins Required for …

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An increased intake of vitamin K2 could be a means of lowering calcium-associated health risks. … Women’s Health Initiative showed that those women taking 1000 mg/day in the form of calciumsupplements, with or without the addition of 400 IU/day of vitamin D, increased their risk of cardiovascular events by 15% to 22%, …

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3 Major Benefits of Vitamin K2 For Your Heart and Bones – Dr. Jockers

New studies are looking at another subtype called vitamin K2 and its effect in synergy with Vitamin D3on various health factors. Vitamin K2 appears to be a very important nutrient … Inadequate K2 inhibits osteocalcin production and reduces calcium flow into bone tissue. This leads to reduced bone mass and a weakened …

Prevent Heart Disease with Vitamins A, D3, and K2 : Terry Talks Nutrition

And that lack of knowledge just might be slowly killing them. Vitamins A, D3, and K2 work as partners to: • Keep calcium in your bones and out of your arteries. • Prevent dangerous blood clots, heart attacks, and high blood pressure. • Help keep arteries flexible and strong. • Reduce inflammatory markers in the bloodstream.

Vitamin K2 and Atherosclerosis | LIfe Extension

In addition, subjects taking the combination of vitamins K2 and D3 showed a reduction in carotid artery calcification score in all patients except those with the highest scores at baseline.6 This indicates thatcalcium was staying in the bones, where it belongs, and out of the arteries. These results clearly indicated that vitamin …

Vitamin Code® RAW Calcium™ | Garden of Life

RAW Whole Food Plant Calcium Formula with Magnesium, Vitamins D3 & K2 (MK-7); Free from Crushed Rock, Limestone, Chalk and Animal Bones … ††Regular exercise and a healthy diet with enough calciumand vitamin D helps you maintain good bone health and may reduce the risk of osteoporosis later in life.

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Klotho enzyme , calcium, insulin , Vitamin D and Alzheimer

Klotho is an enzyme that in humans is encoded by the KL gene.[5]

This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing, bone loss and alcohol consumption.[6][7]Transgenic mice that overexpress Klotho live longer than wild-type mice.[8]

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Function

Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in aging. Its discovery was documented in 1997 by Kuro-o et al.[9] The name of the gene comes from Klotho or Clotho, one of the Moirai, or Fates, in Greek mythology.

The Klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β-glucuronides. Genetic variants in KLOTHO have been associated with human aging,[10][11] and Klotho protein has been shown to be a circulating factor detectable in serum that declines with age.[12]

The binding of certain fibroblast growth factors (FGF’s) viz., FGF19, FGF20, and FGR23, to their Fibroblast growth factor receptors, is promoted by their interaction with Klotho.[13]

Klotho-deficient mice manifest a syndrome resembling accelerated human aging and display extensive and accelerated arteriosclerosis. Additionally, they exhibit impaired endothelium dependent vasodilation and impaired angiogenesis, suggesting that Klotho protein may protect the cardiovascular system through endothelium-derived NO production.

Although the vast majority of research has been based on lack of Klotho, it was demonstrated that an overexpression of Klotho in mice might extend their average life span between 19% and 31% compared to normal mice.[8] In addition, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations.[14]

The mechanism of action of klotho is not fully understood, but it changes cellular calcium homeostasis, by both increasing the expression and activity of TRPV5 and decreasing that of TRPC6.[15] Additionally, klotho increases membrane expression of the inward rectifier channel ROMK.[15]

Klotho-deficient mice show increased production of vitamin D, and altered mineral-ion homeostasis is suggested to be a cause of premature aging‑like phenotypes.

Because the lowering of vitamin D activity by dietary restriction reverses the premature aging‑like phenotypes and prolongs survival in these mutants.

These results suggest that aging‑like phenotypes were due to klotho-associated vitamin D metabolic abnormalities (hypervitaminosis).