Klotho is an enzyme that in humans is encoded by the KL gene.[5] This gene encodes a type-I membrane protein that is related to β-glucuronidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen inContinue reading “Klotho enzyme , calcium, insulin , Vitamin D and Alzheimer”