Orphan opioid. Science 03 Nov 1995: Vol. 270, Issue 5237, pp. 713. DOI: 10.1126/science.270.5237.713f. Article · Info & Metrics · eLetters. Loading. Science: 270 (5237) …

Although studies indicate that the opioid system controls mood-related processes and social behaviors, whether and how stressful childhood experiences impact the opioid system to increase risk for psychopathology and suicide remain unknown. Because epigenetic factors, including DNA methylation, are implicated as the …

Opioid Receptor Mechanism. Gianluigi Tanda, Francesco E. Pontieri,* Gaetano Di Chiara†. The effects of the active ingredient of Cannabis, 9-tetrahydrocannabinol (9-THC), and of the highly addictive drug heroin on in vivo dopamine transmission in the nucleus accumbens were compared in Sprague-Dawley rats by brain …

Individuals homozygous for themet¹⁵⁸ allele of the catechol-O-methyltransferase (COMT) polymorphism (val¹⁵⁸met) showed diminished regional μ-opioid system responses to pain compared with heterozygotes. These effects were accompanied by higher sensory and affective ratings of pain and a more negative internal …

Treatment of rats with a 5-HT4 receptor–specific agonist overcame fentanyl-induced respiratory depression and reestablished stable respiratory rhythm without loss of fentanyl’s analgesic effect. These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of …

The transcript for proenkephalin A, which can be cleaved to produce various bioactive peptides, including those acting on opioid receptors, and various proenkephalin A–derived peptide fragments were abundant in SCH cells. Secretion of the stress-responsive hormone glucocorticoid is circadian, and female, but not male, …

The Mice That Don’t Miss Mom: Love and the μ-Opioid Receptor. Mary Beckman*. Mary Beckman is a writer based in southeastern Idaho. See allHide authors and affiliations. Science 25 Jun 2004: Vol. 304, Issue 5679, pp. 1888-1889. DOI: 10.1126/science.304.5679.1888a. Mary Beckman. Mary Beckman is a writer based …

Abstract. Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, …

Figure 2. (A), (C), and (E) show the effects of ABT-594 (squares), (−)−nicotine (circles), and morphine (triangles) in preclinical models of acute, persistent, and neuropathic pain. All compounds were administered ip. Each compound was tested independently, but for graphical presentation, control (that is, saline-treated …

Synthesizing the opioid peptides. See allHide authors and affiliations. Science 22 Apr 1983: Vol. 220, Issue 4595, pp. 395-397. DOI: 10.1126/science.6836282. JL Marx. Find this author on Google Scholar · Find this author on PubMed · Search for this author on this site · Article; Info & Metrics; eLetters; PDF. Loading.