Blood Cancer (BC) Risk Factor
1.0 = 0.2 + 0.2 + 0.1 + 0.2 + 0.1 + 0.1 + 0.1
©Connie Dello Buono 15Sept2016
- Sex M=0.2 , F = 0.1
- Age > 15 yrs = 0.2 , < 15 yrs =0.1
- Race = 0.1 (South Asian, Caucasian)
- Prenatal exposure to x-rays/chemicals/alcohol ; = 0.2
- Environmental toxins, therapeutic radiation ; previous cancer treatment: Certain types of chemotherapy and radiation therapy for other cancers are considered leukemia risk factors ; smoking ; Diabetes 0.1
- Specific genetic syndromes ; Down syndrome ; 0.1
- Virus = 0.1
BC Risk Factor =1.0 (High) ; BC Risk Factor =
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Modified Blood Risk Factor
| Sex Male = 0.2 Female =0.1 |
Age > 15yrs=0.2 15yrs <= 0.1 |
Race = 0.1 (south asian) |
| Prenatal exposure to x-rays, chemicals, medications/drugs, alcohol = 0.2 | Environmental toxins, therapeutic radiation , non-ionizing radiation,; previous cancer treatment: Certain types of chemotherapy and radiation therapy for other
|
Metabolic and diet: Diabetes 0.1 |
| smoking = 0.1 | Specific genetic syndromes ; Down syndrome = 0.1
Polymorphic alleles of the human leukocyte antigen (HLA) class II genes = 0.1 |
Weak immune and metabolic system: Infection and allergy 0.1 |
Prenatal health of mother may contribute to childhood leukemia
Prenatal exposure to x-rays, and genetic syndromes chromosomal alterations and mutations that disrupt the normal process by which lymphoid or myeloid progenitor cells differentiate and senesce. The underlying triggers for molecular damage may be inherited during pregnancy and may develop during infancy and childhood. These translocations are a ‘‘hallmark’’ genetic event in leukemia. Many leukemia patients have a chromosomal translocation that is often the only observable cytogenetic aberration. These abnormalities help categorize leukemia for treatment strategy and prognosis and may also delineate specific causal pathways to malignancy.
Recently, genetic backtracking analyses, using archived newborn blood specimens and pretreatment bone marrow or peripheral blood specimens obtained at the time of diagnosis, have been applied to study the timing of various translocations. To date, a prenatal origin has been established for several chromosomal abnormalities.
This link points to environmental carcinogens as one of the causes of blood cancer – > http://superfund.berkeley.edu/pdf/28.pdf
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